Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SO4 A 246 |
| Chain | Residue |
| A | ARG48 |
| A | HOH559 |
| A | HOH568 |
| A | HOH596 |
| A | HOH635 |
| A | HOH698 |
| A | HOH707 |
| A | HOH718 |
| A | HOH719 |
| A | ARG120 |
| A | GLN237 |
| A | TYR238 |
| A | HOH389 |
| A | HOH390 |
| A | HOH391 |
| A | HOH485 |
| A | HOH534 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SO4 A 247 |
| Chain | Residue |
| A | ALA15 |
| A | ASN15 |
| A | ARG230 |
| A | PRO233 |
| A | HOH333 |
| A | HOH403 |
| A | HOH434 |
| A | HOH460 |
| A | HOH488 |
| A | HOH509 |
| A | HOH633 |
| A | HOH634 |
| A | HOH643 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SO4 A 248 |
| Chain | Residue |
| A | HIS57 |
| A | ARG122 |
| A | ARG192 |
| A | GLY193 |
| A | SER195 |
| A | GOL253 |
| A | HOH424 |
| A | HOH459 |
| A | HOH491 |
| A | HOH668 |
| A | HOH669 |
| A | HOH670 |
| A | HOH671 |
| A | HOH676 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 203 |
| Chain | Residue |
| A | THR59 |
| A | VAL59 |
| A | ARG90 |
| A | HOH386 |
| A | HOH393 |
| A | HOH468 |
| A | HOH562 |
| A | HOH626 |
| A | HOH627 |
| A | HOH708 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SO4 A 204 |
| Chain | Residue |
| A | ALA48 |
| A | THR49 |
| A | SER110 |
| A | ALA176 |
| A | ARG178 |
| A | HOH309 |
| A | HOH349 |
| A | HOH461 |
| A | HOH555 |
| A | HOH573 |
| A | HOH661 |
| A | HOH662 |
| A | HOH730 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 205 |
| Chain | Residue |
| A | THR168 |
| A | ARG178 |
| A | HOH417 |
| A | HOH549 |
| A | HOH709 |
| A | HOH731 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 206 |
| Chain | Residue |
| A | GLN219 |
| A | SER219 |
| A | HOH353 |
| A | HOH355 |
| A | HOH630 |
| A | HOH700 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 249 |
| Chain | Residue |
| A | ASN36 |
| A | THR62 |
| A | ARG65 |
| A | HOH365 |
| A | HOH599 |
| A | HOH701 |
| A | HOH702 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 250 |
| Chain | Residue |
| A | ALA131 |
| A | VAL132 |
| A | LYS165 |
| A | HOH566 |
| A | HOH646 |
| A | HOH703 |
| A | HOH711 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE SO4 A 251 |
| Chain | Residue |
| A | HOH529 |
| A | HOH548 |
| A | HOH567 |
| A | HOH590 |
| A | HOH611 |
| A | HOH623 |
| A | HOH665 |
| A | HOH674 |
| A | HOH712 |
| A | ARG141 |
| A | HOH314 |
| A | HOH380 |
| A | HOH432 |
| A | HOH527 |
| A | HOH528 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 252 |
| Chain | Residue |
| A | ASN217 |
| A | GLN219 |
| A | HOH569 |
| A | HOH679 |
| A | HOH720 |
| A | HOH721 |
| A | HOH722 |
| site_id | BC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GOL A 253 |
| Chain | Residue |
| A | HIS57 |
| A | ARG122 |
| A | TYR171 |
| A | GLU174 |
| A | ARG192 |
| A | SER214 |
| A | GLY215 |
| A | SO4248 |
| A | HOH337 |
| A | HOH474 |
| A | HOH477 |
| A | HOH491 |
| A | HOH629 |
| A | HOH671 |
| A | HOH745 |
| site_id | BC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 254 |
| Chain | Residue |
| A | PHE120 |
| A | VAL120 |
| A | THR120 |
| A | ALA173 |
| A | GLU174 |
| A | HOH489 |
| A | HOH531 |
| A | HOH532 |
| A | HOH576 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAGHC |
| Chain | Residue | Details |
| A | VAL53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. CMgrGDSGGSWI |
| Chain | Residue | Details |
| A | CYS189-ILE200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS57 | |
| A | ASP102 | |
| A | SER195 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1ssx |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | GLY193 | |
| A | HIS57 | |
| A | SER214 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1ssx |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | GLY193 | |
| A | HIS57 | |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 609 |
| Chain | Residue | Details |
| A | HIS57 | proton acceptor, proton donor |
| A | ASP102 | electrostatic stabiliser |
| A | GLY193 | electrostatic stabiliser |
| A | SER195 | electrostatic stabiliser |
| A | SER214 | electrostatic stabiliser |
