Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004252 | molecular_function | serine-type endopeptidase activity |
A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE SO4 A 246 |
Chain | Residue |
A | ARG48 |
A | HOH559 |
A | HOH568 |
A | HOH596 |
A | HOH635 |
A | HOH698 |
A | HOH707 |
A | HOH718 |
A | HOH719 |
A | ARG120 |
A | GLN237 |
A | TYR238 |
A | HOH389 |
A | HOH390 |
A | HOH391 |
A | HOH485 |
A | HOH534 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE SO4 A 247 |
Chain | Residue |
A | ALA15 |
A | ASN15 |
A | ARG230 |
A | PRO233 |
A | HOH333 |
A | HOH403 |
A | HOH434 |
A | HOH460 |
A | HOH488 |
A | HOH509 |
A | HOH633 |
A | HOH634 |
A | HOH643 |
site_id | AC3 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE SO4 A 248 |
Chain | Residue |
A | HIS57 |
A | ARG122 |
A | ARG192 |
A | GLY193 |
A | SER195 |
A | GOL253 |
A | HOH424 |
A | HOH459 |
A | HOH491 |
A | HOH668 |
A | HOH669 |
A | HOH670 |
A | HOH671 |
A | HOH676 |
site_id | AC4 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE SO4 A 203 |
Chain | Residue |
A | THR59 |
A | VAL59 |
A | ARG90 |
A | HOH386 |
A | HOH393 |
A | HOH468 |
A | HOH562 |
A | HOH626 |
A | HOH627 |
A | HOH708 |
site_id | AC5 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE SO4 A 204 |
Chain | Residue |
A | ALA48 |
A | THR49 |
A | SER110 |
A | ALA176 |
A | ARG178 |
A | HOH309 |
A | HOH349 |
A | HOH461 |
A | HOH555 |
A | HOH573 |
A | HOH661 |
A | HOH662 |
A | HOH730 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 205 |
Chain | Residue |
A | THR168 |
A | ARG178 |
A | HOH417 |
A | HOH549 |
A | HOH709 |
A | HOH731 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 206 |
Chain | Residue |
A | GLN219 |
A | SER219 |
A | HOH353 |
A | HOH355 |
A | HOH630 |
A | HOH700 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 249 |
Chain | Residue |
A | ASN36 |
A | THR62 |
A | ARG65 |
A | HOH365 |
A | HOH599 |
A | HOH701 |
A | HOH702 |
site_id | AC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 250 |
Chain | Residue |
A | ALA131 |
A | VAL132 |
A | LYS165 |
A | HOH566 |
A | HOH646 |
A | HOH703 |
A | HOH711 |
site_id | BC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE SO4 A 251 |
Chain | Residue |
A | HOH529 |
A | HOH548 |
A | HOH567 |
A | HOH590 |
A | HOH611 |
A | HOH623 |
A | HOH665 |
A | HOH674 |
A | HOH712 |
A | ARG141 |
A | HOH314 |
A | HOH380 |
A | HOH432 |
A | HOH527 |
A | HOH528 |
site_id | BC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 252 |
Chain | Residue |
A | ASN217 |
A | GLN219 |
A | HOH569 |
A | HOH679 |
A | HOH720 |
A | HOH721 |
A | HOH722 |
site_id | BC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE GOL A 253 |
Chain | Residue |
A | HIS57 |
A | ARG122 |
A | TYR171 |
A | GLU174 |
A | ARG192 |
A | SER214 |
A | GLY215 |
A | SO4248 |
A | HOH337 |
A | HOH474 |
A | HOH477 |
A | HOH491 |
A | HOH629 |
A | HOH671 |
A | HOH745 |
site_id | BC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL A 254 |
Chain | Residue |
A | PHE120 |
A | VAL120 |
A | THR120 |
A | ALA173 |
A | GLU174 |
A | HOH489 |
A | HOH531 |
A | HOH532 |
A | HOH576 |
Functional Information from PROSITE/UniProt
site_id | PS00134 |
Number of Residues | 6 |
Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAGHC |
Chain | Residue | Details |
A | VAL53-CYS58 | |
site_id | PS00135 |
Number of Residues | 12 |
Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. CMgrGDSGGSWI |
Chain | Residue | Details |
A | CYS189-ILE200 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | ACT_SITE: Charge relay system => ECO:0000250 |
Chain | Residue | Details |
A | HIS57 | |
A | ASP102 | |
A | SER195 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 5 |
Details | Annotated By Reference To The Literature 1ssx |
Chain | Residue | Details |
A | ASP102 | |
A | SER195 | |
A | GLY193 | |
A | HIS57 | |
A | SER214 | |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1ssx |
Chain | Residue | Details |
A | ASP102 | |
A | SER195 | |
A | GLY193 | |
A | HIS57 | |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 609 |
Chain | Residue | Details |
A | HIS57 | proton acceptor, proton donor |
A | ASP102 | electrostatic stabiliser |
A | GLY193 | electrostatic stabiliser |
A | SER195 | electrostatic stabiliser |
A | SER214 | electrostatic stabiliser |