2H57
Crystal structure of human ADP-ribosylation factor-like 6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005879 | cellular_component | axonemal microtubule |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005929 | cellular_component | cilium |
| A | 0005930 | cellular_component | axoneme |
| A | 0006612 | biological_process | protein targeting to membrane |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0007368 | biological_process | determination of left/right symmetry |
| A | 0016020 | cellular_component | membrane |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0030117 | cellular_component | membrane coat |
| A | 0032402 | biological_process | melanosome transport |
| A | 0045444 | biological_process | fat cell differentiation |
| A | 0051258 | biological_process | protein polymerization |
| A | 0060271 | biological_process | cilium assembly |
| A | 0061512 | biological_process | protein localization to cilium |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0097499 | biological_process | protein localization to non-motile cilium |
| A | 0097542 | cellular_component | ciliary tip |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005879 | cellular_component | axonemal microtubule |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005929 | cellular_component | cilium |
| B | 0005930 | cellular_component | axoneme |
| B | 0006612 | biological_process | protein targeting to membrane |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0007368 | biological_process | determination of left/right symmetry |
| B | 0016020 | cellular_component | membrane |
| B | 0016055 | biological_process | Wnt signaling pathway |
| B | 0030117 | cellular_component | membrane coat |
| B | 0032402 | biological_process | melanosome transport |
| B | 0045444 | biological_process | fat cell differentiation |
| B | 0051258 | biological_process | protein polymerization |
| B | 0060271 | biological_process | cilium assembly |
| B | 0061512 | biological_process | protein localization to cilium |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0097499 | biological_process | protein localization to non-motile cilium |
| B | 0097542 | cellular_component | ciliary tip |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005543 | molecular_function | phospholipid binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005879 | cellular_component | axonemal microtubule |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0005929 | cellular_component | cilium |
| C | 0005930 | cellular_component | axoneme |
| C | 0006612 | biological_process | protein targeting to membrane |
| C | 0006886 | biological_process | intracellular protein transport |
| C | 0007368 | biological_process | determination of left/right symmetry |
| C | 0016020 | cellular_component | membrane |
| C | 0016055 | biological_process | Wnt signaling pathway |
| C | 0030117 | cellular_component | membrane coat |
| C | 0032402 | biological_process | melanosome transport |
| C | 0045444 | biological_process | fat cell differentiation |
| C | 0051258 | biological_process | protein polymerization |
| C | 0060271 | biological_process | cilium assembly |
| C | 0061512 | biological_process | protein localization to cilium |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0097499 | biological_process | protein localization to non-motile cilium |
| C | 0097542 | cellular_component | ciliary tip |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 202 |
| Chain | Residue |
| A | THR31 |
| A | THR50 |
| A | GTP201 |
| A | HOH401 |
| A | HOH402 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 202 |
| Chain | Residue |
| B | HOH407 |
| B | THR31 |
| B | THR50 |
| B | GTP201 |
| B | HOH406 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 202 |
| Chain | Residue |
| C | THR31 |
| C | THR50 |
| C | GTP201 |
| C | HOH410 |
| C | HOH411 |
| site_id | AC4 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE GTP A 201 |
| Chain | Residue |
| A | LEU25 |
| A | ASP26 |
| A | ASN27 |
| A | SER28 |
| A | GLY29 |
| A | LYS30 |
| A | THR31 |
| A | THR32 |
| A | ILE47 |
| A | THR50 |
| A | SER71 |
| A | GLY72 |
| A | ASN130 |
| A | LYS131 |
| A | ASP133 |
| A | LEU134 |
| A | ASP163 |
| A | ALA164 |
| A | ILE165 |
| A | MG202 |
| A | HOH308 |
| A | HOH325 |
| A | HOH340 |
| A | HOH401 |
| A | HOH402 |
| A | HOH403 |
| C | ARG75 |
| site_id | AC5 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE GTP B 201 |
| Chain | Residue |
| B | ASP26 |
| B | ASN27 |
| B | SER28 |
| B | GLY29 |
| B | LYS30 |
| B | THR31 |
| B | THR32 |
| B | ILE47 |
| B | THR50 |
| B | SER71 |
| B | GLY72 |
| B | ASN130 |
| B | LYS131 |
| B | ASP133 |
| B | LEU134 |
| B | ASP163 |
| B | ALA164 |
| B | ILE165 |
| B | MG202 |
| B | HOH322 |
| B | HOH406 |
| B | HOH407 |
| B | HOH408 |
| B | HOH427 |
| B | HOH430 |
| site_id | AC6 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE GTP C 201 |
| Chain | Residue |
| C | ASP26 |
| C | ASN27 |
| C | SER28 |
| C | GLY29 |
| C | LYS30 |
| C | THR31 |
| C | THR32 |
| C | ILE47 |
| C | THR50 |
| C | GLY72 |
| C | ASN130 |
| C | LYS131 |
| C | ASP133 |
| C | LEU134 |
| C | ASP163 |
| C | ALA164 |
| C | ILE165 |
| C | MG202 |
| C | HOH312 |
| C | HOH314 |
| C | HOH319 |
| C | HOH358 |
| C | HOH410 |
| C | HOH411 |
| C | HOH412 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX C 501 |
| Chain | Residue |
| A | ARG101 |
| C | ARG101 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX B 502 |
| Chain | Residue |
| B | GLY74 |
| B | ARG75 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX A 503 |
| Chain | Residue |
| A | GLN45 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 504 |
| Chain | Residue |
| A | LYS142 |
| B | ARG99 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX B 506 |
| Chain | Residue |
| A | GLU168 |
| A | HOH341 |
| B | SER140 |
| B | VAL141 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX A 508 |
| Chain | Residue |
| A | ARG77 |
| A | ASN78 |
| A | TRP80 |
| A | GLU81 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX C 509 |
| Chain | Residue |
| C | LEU134 |
| C | ARG135 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20207729","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | GLN73 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | GLN73 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| C | GLN73 |
