Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2H57

Crystal structure of human ADP-ribosylation factor-like 6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005543	molecular_function	phospholipid binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005879	cellular_component	axonemal microtubule
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0005930	cellular_component	axoneme
A	0006612	biological_process	protein targeting to membrane
A	0006886	biological_process	intracellular protein transport
A	0007368	biological_process	determination of left/right symmetry
A	0007601	biological_process	visual perception
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0016055	biological_process	Wnt signaling pathway
A	0016192	biological_process	vesicle-mediated transport
A	0030030	biological_process	cell projection organization
A	0030117	cellular_component	membrane coat
A	0032402	biological_process	melanosome transport
A	0045444	biological_process	fat cell differentiation
A	0046872	molecular_function	metal ion binding
A	0051258	biological_process	protein polymerization
A	0060271	biological_process	cilium assembly
A	0061512	biological_process	protein localization to cilium
A	0070062	cellular_component	extracellular exosome
A	0097499	biological_process	protein localization to non-motile cilium
A	0097542	cellular_component	ciliary tip
B	0000166	molecular_function	nucleotide binding
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005543	molecular_function	phospholipid binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005879	cellular_component	axonemal microtubule
B	0005886	cellular_component	plasma membrane
B	0005929	cellular_component	cilium
B	0005930	cellular_component	axoneme
B	0006612	biological_process	protein targeting to membrane
B	0006886	biological_process	intracellular protein transport
B	0007368	biological_process	determination of left/right symmetry
B	0007601	biological_process	visual perception
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0016055	biological_process	Wnt signaling pathway
B	0016192	biological_process	vesicle-mediated transport
B	0030030	biological_process	cell projection organization
B	0030117	cellular_component	membrane coat
B	0032402	biological_process	melanosome transport
B	0045444	biological_process	fat cell differentiation
B	0046872	molecular_function	metal ion binding
B	0051258	biological_process	protein polymerization
B	0060271	biological_process	cilium assembly
B	0061512	biological_process	protein localization to cilium
B	0070062	cellular_component	extracellular exosome
B	0097499	biological_process	protein localization to non-motile cilium
B	0097542	cellular_component	ciliary tip
C	0000166	molecular_function	nucleotide binding
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005543	molecular_function	phospholipid binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005879	cellular_component	axonemal microtubule
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0005930	cellular_component	axoneme
C	0006612	biological_process	protein targeting to membrane
C	0006886	biological_process	intracellular protein transport
C	0007368	biological_process	determination of left/right symmetry
C	0007601	biological_process	visual perception
C	0015031	biological_process	protein transport
C	0016020	cellular_component	membrane
C	0016055	biological_process	Wnt signaling pathway
C	0016192	biological_process	vesicle-mediated transport
C	0030030	biological_process	cell projection organization
C	0030117	cellular_component	membrane coat
C	0032402	biological_process	melanosome transport
C	0045444	biological_process	fat cell differentiation
C	0046872	molecular_function	metal ion binding
C	0051258	biological_process	protein polymerization
C	0060271	biological_process	cilium assembly
C	0061512	biological_process	protein localization to cilium
C	0070062	cellular_component	extracellular exosome
C	0097499	biological_process	protein localization to non-motile cilium
C	0097542	cellular_component	ciliary tip

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 202

Chain	Residue
A	THR31
A	THR50
A	GTP201
A	HOH401
A	HOH402

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 202

Chain	Residue
B	HOH407
B	THR31
B	THR50
B	GTP201
B	HOH406

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 202

Chain	Residue
C	THR31
C	THR50
C	GTP201
C	HOH410
C	HOH411

site_id	AC4
Number of Residues	27
Details	BINDING SITE FOR RESIDUE GTP A 201

Chain	Residue
A	LEU25
A	ASP26
A	ASN27
A	SER28
A	GLY29
A	LYS30
A	THR31
A	THR32
A	ILE47
A	THR50
A	SER71
A	GLY72
A	ASN130
A	LYS131
A	ASP133
A	LEU134
A	ASP163
A	ALA164
A	ILE165
A	MG202
A	HOH308
A	HOH325
A	HOH340
A	HOH401
A	HOH402
A	HOH403
C	ARG75

site_id	AC5
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GTP B 201

Chain	Residue
B	ASP26
B	ASN27
B	SER28
B	GLY29
B	LYS30
B	THR31
B	THR32
B	ILE47
B	THR50
B	SER71
B	GLY72
B	ASN130
B	LYS131
B	ASP133
B	LEU134
B	ASP163
B	ALA164
B	ILE165
B	MG202
B	HOH322
B	HOH406
B	HOH407
B	HOH408
B	HOH427
B	HOH430

site_id	AC6
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GTP C 201

Chain	Residue
C	ASP26
C	ASN27
C	SER28
C	GLY29
C	LYS30
C	THR31
C	THR32
C	ILE47
C	THR50
C	GLY72
C	ASN130
C	LYS131
C	ASP133
C	LEU134
C	ASP163
C	ALA164
C	ILE165
C	MG202
C	HOH312
C	HOH314
C	HOH319
C	HOH358
C	HOH410
C	HOH411
C	HOH412

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX C 501

Chain	Residue
A	ARG101
C	ARG101

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX B 502

Chain	Residue
B	GLY74
B	ARG75

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UNX A 503

Chain	Residue
A	GLN45

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX A 504

Chain	Residue
A	LYS142
B	ARG99

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE UNX B 506

Chain	Residue
A	GLU168
A	HOH341
B	SER140
B	VAL141

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE UNX A 508

Chain	Residue
A	ARG77
A	ASN78
A	TRP80
A	GLU81

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX C 509

Chain	Residue
C	LEU134
C	ARG135

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20207729","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN73

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	GLN73

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	GLN73

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)