2H4X
Human bisphosphoglycerate mutase complex with 3-phosphoglycerate with crystal growth 90 days
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004082 | molecular_function | bisphosphoglycerate mutase activity |
| A | 0004619 | molecular_function | phosphoglycerate mutase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0006753 | biological_process | nucleoside phosphate metabolic process |
| A | 0007585 | biological_process | respiratory gaseous exchange by respiratory system |
| A | 0015671 | biological_process | oxygen transport |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016868 | molecular_function | intramolecular phosphotransferase activity |
| A | 0033554 | biological_process | cellular response to stress |
| A | 0042832 | biological_process | defense response to protozoan |
| A | 0046538 | molecular_function | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity |
| A | 0048821 | biological_process | erythrocyte development |
| A | 0060856 | biological_process | establishment of blood-brain barrier |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0150076 | biological_process | neuroinflammatory response |
| A | 1901136 | biological_process | carbohydrate derivative catabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004082 | molecular_function | bisphosphoglycerate mutase activity |
| B | 0004619 | molecular_function | phosphoglycerate mutase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0006753 | biological_process | nucleoside phosphate metabolic process |
| B | 0007585 | biological_process | respiratory gaseous exchange by respiratory system |
| B | 0015671 | biological_process | oxygen transport |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0016868 | molecular_function | intramolecular phosphotransferase activity |
| B | 0033554 | biological_process | cellular response to stress |
| B | 0042832 | biological_process | defense response to protozoan |
| B | 0046538 | molecular_function | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity |
| B | 0048821 | biological_process | erythrocyte development |
| B | 0060856 | biological_process | establishment of blood-brain barrier |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0150076 | biological_process | neuroinflammatory response |
| B | 1901136 | biological_process | carbohydrate derivative catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 3PG A 1408 |
| Chain | Residue |
| A | ARG10 |
| A | ASN190 |
| A | HOH1410 |
| A | HOH1448 |
| A | HOH1472 |
| A | HOH1564 |
| A | HOH1619 |
| A | HOH1620 |
| A | PHE22 |
| A | CYS23 |
| A | SER24 |
| A | GLU89 |
| A | TYR92 |
| A | ARG100 |
| A | ARG116 |
| A | ARG117 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 3PG B 2408 |
| Chain | Residue |
| B | ARG10 |
| B | PHE22 |
| B | CYS23 |
| B | SER24 |
| B | GLU89 |
| B | TYR92 |
| B | ARG100 |
| B | ARG116 |
| B | ARG117 |
| B | ASN190 |
| B | HOH2420 |
| B | HOH2423 |
| B | HOH2451 |
| B | HOH2608 |
| B | HOH2609 |
| B | HOH2683 |
Functional Information from PROSITE/UniProt
| site_id | PS00175 |
| Number of Residues | 10 |
| Details | PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. MlRHGEgAwN |
| Chain | Residue | Details |
| A | MET8-ASN17 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Tele-phosphohistidine intermediate => ECO:0000269|PubMed:17052986 |
| Chain | Residue | Details |
| A | HIS11 | |
| B | HIS11 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:17052986 |
| Chain | Residue | Details |
| A | GLU89 | |
| B | GLU89 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17052986 |
| Chain | Residue | Details |
| A | ARG10 | |
| B | ARG62 | |
| B | GLU89 | |
| B | ARG100 | |
| B | ARG116 | |
| B | GLY189 | |
| A | CYS23 | |
| A | ARG62 | |
| A | GLU89 | |
| A | ARG100 | |
| A | ARG116 | |
| A | GLY189 | |
| B | ARG10 | |
| B | CYS23 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:9832630 |
| Chain | Residue | Details |
| A | LYS29 | |
| B | LYS46 | |
| B | LYS143 | |
| B | LYS181 | |
| B | LYS246 | |
| B | LYS247 | |
| B | LYS253 | |
| B | LYS258 | |
| A | LYS46 | |
| A | LYS143 | |
| A | LYS181 | |
| A | LYS246 | |
| A | LYS247 | |
| A | LYS253 | |
| A | LYS258 | |
| B | LYS29 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:17052986 |
| Chain | Residue | Details |
| A | HIS188 | |
| B | HIS188 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | SER2 | |
| B | SER2 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR122 | |
| B | THR122 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:9832630 |
| Chain | Residue | Details |
| A | LYS3 | |
| B | LYS197 | |
| A | LYS5 | |
| A | LYS18 | |
| A | LYS43 | |
| A | LYS197 | |
| B | LYS3 | |
| B | LYS5 | |
| B | LYS18 | |
| B | LYS43 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:9832630 |
| Chain | Residue | Details |
| A | LYS159 | |
| B | LYS159 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1qhf |
| Chain | Residue | Details |
| A | ARG62 | |
| A | HIS11 | |
| A | GLU89 | |
| A | HIS188 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1qhf |
| Chain | Residue | Details |
| B | ARG62 | |
| B | HIS11 | |
| B | GLU89 | |
| B | HIS188 |
