2H3W
Crystal structure of the S554A/M564G mutant of murine carnitine acetyltransferase in complex with hexanoylcarnitine and CoA
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003997 | molecular_function | acyl-CoA oxidase activity |
A | 0004092 | molecular_function | carnitine O-acetyltransferase activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0005743 | cellular_component | mitochondrial inner membrane |
A | 0005777 | cellular_component | peroxisome |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0006631 | biological_process | fatty acid metabolic process |
A | 0008458 | molecular_function | carnitine O-octanoyltransferase activity |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0019254 | biological_process | carnitine metabolic process, CoA-linked |
A | 0033540 | biological_process | fatty acid beta-oxidation using acyl-CoA oxidase |
A | 0046459 | biological_process | short-chain fatty acid metabolic process |
A | 0051791 | biological_process | medium-chain fatty acid metabolic process |
B | 0003997 | molecular_function | acyl-CoA oxidase activity |
B | 0004092 | molecular_function | carnitine O-acetyltransferase activity |
B | 0005739 | cellular_component | mitochondrion |
B | 0005743 | cellular_component | mitochondrial inner membrane |
B | 0005777 | cellular_component | peroxisome |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0006631 | biological_process | fatty acid metabolic process |
B | 0008458 | molecular_function | carnitine O-octanoyltransferase activity |
B | 0016746 | molecular_function | acyltransferase activity |
B | 0019254 | biological_process | carnitine metabolic process, CoA-linked |
B | 0033540 | biological_process | fatty acid beta-oxidation using acyl-CoA oxidase |
B | 0046459 | biological_process | short-chain fatty acid metabolic process |
B | 0051791 | biological_process | medium-chain fatty acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE COA A 1601 |
Chain | Residue |
A | LEU163 |
A | SER428 |
A | PRO429 |
A | ASP430 |
A | ALA455 |
A | SER456 |
A | ARG504 |
A | THR507 |
A | ILE511 |
A | GLN555 |
A | HC51602 |
A | HIS343 |
A | HOH1690 |
A | HOH1769 |
A | HOH1777 |
A | HOH1789 |
A | HOH1811 |
A | HOH1816 |
A | HOH1925 |
A | HOH1951 |
A | HOH2165 |
A | GLU347 |
A | GLY348 |
A | PRO349 |
A | LYS419 |
A | LYS423 |
A | LYS426 |
A | LEU427 |
site_id | AC2 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE COA B 1701 |
Chain | Residue |
B | LEU163 |
B | GLU347 |
B | GLY348 |
B | PRO349 |
B | LYS419 |
B | LYS423 |
B | LYS426 |
B | LEU427 |
B | SER428 |
B | PRO429 |
B | ASP430 |
B | SER454 |
B | ALA455 |
B | SER456 |
B | ARG504 |
B | THR507 |
B | ILE511 |
B | GLN555 |
B | HC51702 |
B | HOH1798 |
B | HOH1902 |
B | HOH1942 |
B | HOH2012 |
B | HOH2094 |
B | HOH2156 |
B | HOH2220 |
B | HOH2229 |
site_id | AC3 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE HC5 A 1602 |
Chain | Residue |
A | TRP102 |
A | PRO120 |
A | VAL122 |
A | TYR341 |
A | HIS343 |
A | GLU347 |
A | TYR452 |
A | SER454 |
A | THR465 |
A | SER552 |
A | ALA554 |
A | VAL556 |
A | PHE566 |
A | VAL569 |
A | COA1601 |
A | HOH1603 |
site_id | AC4 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE HC5 B 1702 |
Chain | Residue |
B | TRP102 |
B | VAL122 |
B | TYR341 |
B | HIS343 |
B | GLU347 |
B | TYR452 |
B | SER454 |
B | THR465 |
B | SER552 |
B | ALA554 |
B | VAL556 |
B | PHE566 |
B | VAL569 |
B | COA1701 |
B | HOH1712 |
Functional Information from PROSITE/UniProt
site_id | PS00439 |
Number of Residues | 16 |
Details | ACYLTRANSF_C_1 Acyltransferases ChoActase / COT / CPT family signature 1. LPrLPVPpLqQSLdyY |
Chain | Residue | Details |
A | LEU35-TYR50 |
site_id | PS00440 |
Number of Residues | 28 |
Details | ACYLTRANSF_C_2 Acyltransferases ChoActase / COT / CPT family signature 2. RWfDKtLqFIvaeDGscgmvyEHaaaEG |
Chain | Residue | Details |
A | ARG321-GLY348 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | HIS343 | |
B | HIS343 |
site_id | SWS_FT_FI2 |
Number of Residues | 14 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12526798, ECO:0000269|PubMed:15155726 |
Chain | Residue | Details |
A | LYS419 | |
B | SER454 | |
B | SER456 | |
B | THR465 | |
B | ARG504 | |
B | GLN555 | |
A | TYR452 | |
A | SER454 | |
A | SER456 | |
A | THR465 | |
A | ARG504 | |
A | GLN555 | |
B | LYS419 | |
B | TYR452 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: |
Chain | Residue | Details |
A | LYS423 | |
B | LYS423 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337 |
Chain | Residue | Details |
A | LYS93 | |
B | LYS93 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0007744|PubMed:23806337 |
Chain | Residue | Details |
A | LYS261 | |
B | LYS261 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P43155 |
Chain | Residue | Details |
A | LYS268 | |
B | LYS268 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ndi |
Chain | Residue | Details |
A | ALA554 | |
A | HIS343 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ndi |
Chain | Residue | Details |
B | ALA554 | |
B | HIS343 |
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 629 |
Chain | Residue | Details |
A | TYR107 | steric role |
A | PRO120 | steric role |
A | HIS343 | hydrogen bond acceptor, proton acceptor, proton donor |
A | ALA554 | electrostatic stabiliser, hydrogen bond donor |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 629 |
Chain | Residue | Details |
B | TYR107 | steric role |
B | PRO120 | steric role |
B | HIS343 | hydrogen bond acceptor, proton acceptor, proton donor |
B | ALA554 | electrostatic stabiliser, hydrogen bond donor |