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2GZ5

Human Type 1 methionine aminopeptidase in complex with ovalicin at 1.1 Ang

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0070006molecular_functionmetalloaminopeptidase activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE CO A 401
ChainResidue
AASP240
AHIS303
AGLU336
AGLU367
ACO402
AOVA480
AHOH711

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CO A 402
ChainResidue
AGLU367
ACO401
AHOH710
AHOH711
AASP229
AASP240

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE CO A 403
ChainResidue
AGLU128
ATYR195
ATYR196
AHIS310
AGOL471
AHOH829
AHOH830

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K A 404
ChainResidue
ASER205
AASN207
AVAL209
ASER363
AHOH623
AHOH828

site_idAC5
Number of Residues12
DetailsBINDING SITE FOR RESIDUE OVA A 480
ChainResidue
ATYR195
APHE198
ACYS203
AHIS212
ATYR300
ACYS301
AGLU336
ACO401
AGOL471
AHOH637
AHOH711
AHOH831

site_idAC6
Number of Residues12
DetailsBINDING SITE FOR RESIDUE GOL A 470
ChainResidue
ALEU96
ATHR172
ATHR204
ASER205
AVAL206
AVAL209
AILE214
AASP216
AARG218
AHOH501
AHOH502
AHOH552

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 471
ChainResidue
ATYR195
AHIS310
ACO403
AOVA480
AHOH637
AHOH830
AHOH831

Functional Information from PROSITE/UniProt
site_idPS00680
Number of Residues19
DetailsMAP_1 Methionine aminopeptidase subfamily 1 signature. YcGHGIHklfHtapnVp.HY
ChainResidueDetails
ATYR300-TYR318

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03174, ECO:0000269|PubMed:16724298, ECO:0000269|PubMed:16823043, ECO:0000269|PubMed:17114291
ChainResidueDetails
AHIS212
AHIS310

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03174, ECO:0000269|PubMed:16274222, ECO:0000269|PubMed:16724298, ECO:0000269|PubMed:16823043, ECO:0000269|PubMed:17114291
ChainResidueDetails
AASP229
AASP240
AHIS303
AGLU336
AGLU367

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PDB entries from 2024-11-06

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