2GZ1
Structure of Aspartate Semialdehyde Dehydrogenase (ASADH) from Streptococcus pneumoniae complexed with NADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009088 | biological_process | L-threonine biosynthetic process |
| A | 0009089 | biological_process | obsolete L-lysine biosynthetic process via diaminopimelate |
| A | 0009097 | biological_process | obsolete isoleucine biosynthetic process |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0046983 | molecular_function | protein dimerization activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
| B | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009088 | biological_process | L-threonine biosynthetic process |
| B | 0009089 | biological_process | obsolete L-lysine biosynthetic process via diaminopimelate |
| B | 0009097 | biological_process | obsolete isoleucine biosynthetic process |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0046983 | molecular_function | protein dimerization activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| B | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAP A 702 |
| Chain | Residue |
| A | GLY9 |
| A | THR57 |
| A | SER71 |
| A | ALA72 |
| A | GLY73 |
| A | THR76 |
| A | ASN94 |
| A | THR95 |
| A | SER158 |
| A | GLY159 |
| A | GLY161 |
| A | THR11 |
| A | MET162 |
| A | ASN325 |
| A | LEU326 |
| A | GLY329 |
| A | HOH779 |
| A | HOH889 |
| A | HOH890 |
| A | HOH961 |
| A | HOH1009 |
| A | HOH1015 |
| A | GLY12 |
| A | ALA13 |
| A | VAL14 |
| A | ALA36 |
| A | SER37 |
| A | ARG39 |
| A | SER40 |
| site_id | AC2 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NAP B 701 |
| Chain | Residue |
| B | GLY9 |
| B | THR11 |
| B | GLY12 |
| B | ALA13 |
| B | VAL14 |
| B | ALA36 |
| B | SER37 |
| B | ARG39 |
| B | SER40 |
| B | THR57 |
| B | SER71 |
| B | ALA72 |
| B | GLY73 |
| B | THR76 |
| B | ASN94 |
| B | THR95 |
| B | CYS128 |
| B | SER158 |
| B | GLY159 |
| B | GLY161 |
| B | MET162 |
| B | ASN325 |
| B | LEU326 |
| B | GLY329 |
| B | HOH730 |
| B | HOH735 |
| B | HOH777 |
| B | HOH812 |
| B | HOH908 |
| B | HOH926 |
| B | HOH1030 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| A | GLN155 | |
| A | HIS252 | |
| A | CYS128 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| B | GLN155 | |
| B | HIS252 | |
| B | CYS128 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| A | GLN155 | |
| A | CYS128 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| B | GLN155 | |
| B | CYS128 |
