2GWH
Human Sulfotranferase SULT1C2 in complex with PAP and pentachlorophenol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004062 | molecular_function | aryl sulfotransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006068 | biological_process | ethanol catabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0008146 | molecular_function | sulfotransferase activity |
| A | 0009812 | biological_process | flavonoid metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0044598 | biological_process | doxorubicin metabolic process |
| A | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| A | 0051923 | biological_process | sulfation |
| B | 0004062 | molecular_function | aryl sulfotransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006068 | biological_process | ethanol catabolic process |
| B | 0006805 | biological_process | xenobiotic metabolic process |
| B | 0008146 | molecular_function | sulfotransferase activity |
| B | 0009812 | biological_process | flavonoid metabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0044598 | biological_process | doxorubicin metabolic process |
| B | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| B | 0051923 | biological_process | sulfation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE A3P A 401 |
| Chain | Residue |
| A | LYS55 |
| A | THR234 |
| A | SER235 |
| A | PHE236 |
| A | MET239 |
| A | PHE262 |
| A | MET263 |
| A | ARG264 |
| A | LYS265 |
| A | GLY266 |
| A | HOH1016 |
| A | ALA56 |
| A | HOH1033 |
| A | HOH1076 |
| A | HOH1119 |
| A | HOH1120 |
| A | HOH1124 |
| A | GLY57 |
| A | THR58 |
| A | THR59 |
| A | TRP60 |
| A | ARG137 |
| A | SER145 |
| A | TYR200 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PCI A 402 |
| Chain | Residue |
| A | ILE93 |
| A | LYS113 |
| A | HIS115 |
| A | PHE149 |
| A | ASN153 |
| A | LEU156 |
| A | TRP176 |
| A | TYR247 |
| A | MET255 |
| A | HOH1120 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE A3P B 401 |
| Chain | Residue |
| B | LYS55 |
| B | ALA56 |
| B | GLY57 |
| B | THR58 |
| B | THR59 |
| B | TRP60 |
| B | ARG137 |
| B | SER145 |
| B | TYR200 |
| B | THR234 |
| B | SER235 |
| B | PHE236 |
| B | MET239 |
| B | PHE262 |
| B | MET263 |
| B | ARG264 |
| B | LYS265 |
| B | GLY266 |
| B | HOH1015 |
| B | HOH1022 |
| B | HOH1038 |
| B | HOH1072 |
| B | HOH1131 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PCI B 402 |
| Chain | Residue |
| B | PHE88 |
| B | ILE93 |
| B | LYS113 |
| B | HIS115 |
| B | ASN153 |
| B | TRP176 |
| B | TYR247 |
| B | MET255 |
| B | HOH1038 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PCI B 501 |
| Chain | Residue |
| B | LYS225 |
| B | ASP228 |
| B | LYS229 |
| B | LYS229 |
| B | HIS232 |
| B | HIS232 |
| B | TYR233 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNX B 1001 |
| Chain | Residue |
| B | ARG194 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX B 1002 |
| Chain | Residue |
| B | GLN301 |
| B | PHE302 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 1003 |
| Chain | Residue |
| A | ASP284 |
| A | LYS288 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 1004 |
| Chain | Residue |
| A | TRP187 |
| A | THR294 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX B 1005 |
| Chain | Residue |
| B | GLU285 |
| B | LYS288 |
| B | HOH1133 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX A 1006 |
| Chain | Residue |
| A | LYS131 |
| A | ARG194 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS115 | |
| B | HIS115 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17425406 |
| Chain | Residue | Details |
| A | LYS55 | |
| B | TYR200 | |
| B | THR234 | |
| B | PHE262 | |
| A | ARG137 | |
| A | SER145 | |
| A | TYR200 | |
| A | THR234 | |
| A | PHE262 | |
| B | LYS55 | |
| B | ARG137 | |
| B | SER145 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS113 | |
| B | LYS113 |
