Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2GUF

In meso crystal structure of the cobalamin transporter, BtuB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0006811	biological_process	monoatomic ion transport
A	0009279	cellular_component	cell outer membrane
A	0015288	molecular_function	porin activity
A	0015420	molecular_function	ABC-type vitamin B12 transporter activity
A	0015889	biological_process	cobalamin transport
A	0016020	cellular_component	membrane
A	0019904	molecular_function	protein domain specific binding
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035461	biological_process	vitamin transmembrane transport
A	0046872	molecular_function	metal ion binding
A	0046930	cellular_component	pore complex
A	0090482	molecular_function	vitamin transmembrane transporter activity
A	1902495	cellular_component	transmembrane transporter complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MPG A 701

Chain	Residue
A	TRP214
A	TYR256
A	ASN302
A	LEU342
A	ALA466
A	VAL479
A	TYR481
A	MPG704
A	MPG705

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE MPG A 702

Chain	Residue
A	ILE140
A	SER141
A	ALA142
A	VAL154
A	ASP171
A	LYS200
A	THR201
A	LEU202
A	GLY222
A	ASP224
A	LEU559
A	GLY590
A	TYR592

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MPG A 703

Chain	Residue
A	LEU254
A	SER263
A	VAL298
A	TRP300
A	VAL315
A	THR338
A	TYR383
A	HOH1143
A	HOH1153

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MPG A 704

Chain	Residue
A	ASN302
A	ALA313
A	GLY314
A	ALA357
A	ARG358
A	GLY369
A	THR370
A	TRP371
A	THR391
A	TRP431
A	ALA468
A	PHE470
A	THR472
A	MPG701
A	MPG705
A	MPD904

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MPG A 705

Chain	Residue
A	ILE311
A	GLY344
A	ALA357
A	TRP371
A	THR472
A	HIS477
A	VAL479
A	VAL503
A	TYR505
A	MPG701
A	MPG704

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPG A 706

Chain	Residue
A	TYR296
A	TRP317
A	LYS319

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MPG A 707

Chain	Residue
A	GLY307
A	GLN346
A	TYR520
A	TYR522
A	SER545
A	MPG711
A	HOH1133
A	HOH1156

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPG A 708

Chain	Residue
A	THR138
A	VAL154
A	TYR221
A	GLN248
A	PHE594
A	HOH1103

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MPG A 709

Chain	Residue
A	LEU160
A	GLY161
A	ASP162
A	LYS163
A	THR164
A	HIS208
A	GLY216
A	PHE217
A	TYR586

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MPG A 710

Chain	Residue
A	THR373
A	SER374
A	ALA375
A	ALA387
A	SER388
A	GLU419
A	GLY420
A	ALA421
A	MPG711

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPG A 711

Chain	Residue
A	MPG710
A	GLN346
A	THR373
A	TYR389
A	LYS416
A	TRP418
A	MPG707

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 801

Chain	Residue
A	THR30
A	ARG31
A	GLN105
A	ARG106
A	HOH1162

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD A 901

Chain	Residue
A	ASN86
A	ASP95
A	TYR223
A	SER272
A	MET293
A	HOH999
A	HOH1051

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD A 902

Chain	Residue
A	GLN318
A	GLN320
A	GLN335
A	ASN337
A	ALA395
A	ASN397
A	HOH1167

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD A 903

Chain	Residue
A	SER91
A	ALA94
A	TYR405
A	TYR446
A	TYR453
A	HOH1026

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD A 904

Chain	Residue
A	SER286
A	SER359
A	HIS368
A	GLY369
A	ALA427
A	ASP471
A	MPG704

Functional Information from PROSITE/UniProt

site_id	PS01156
Number of Residues	18
Details	TONB_DEPENDENT_REC_2 TonB-dependent receptor (TBDR) proteins signature 2. YgyqTaGReYtLSGsYtF

Chain	Residue	Details
A	TYR577-PHE594

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	168
Details	TOPO_DOM: Periplasmic => ECO:0000269\|PubMed:12652322

Chain	Residue	Details
A	GLN1-GLY137
A	GLN510-PHE514
A	TYR553-LYS564
A	GLN159-LYS163
A	HIS208-THR211
A	GLY258
A	VAL306-GLY307
A	ASP350
A	GLU381-GLY382
A	GLY424-GLY428
A	ASP471-GLY473

site_id	SWS_FT_FI2
Number of Residues	278
Details	TRANSMEM: Beta stranded

Chain	Residue	Details
A	THR138-GLY145
A	TYR333-GLY349
A	PHE351-ASP361
A	PHE365-ILE380
A	TYR383-ASN397
A	LYS414-GLU423
A	VAL429-ASN438
A	TYR453-PHE470
A	PRO474-ALA489
A	ARG497-TRP509
A	ASP515-ASP530
A	TYR149-GLN158
A	THR538-ALA552
A	ILE565-VAL576
A	ALA582-PHE594
A	THR164-THR175
A	PHE197-GLU207
A	ASP212-ASN228
A	ARG243-ASN257
A	GLU259-ASN276
A	THR289-ILE305
A	HIS308-TRP317

site_id	SWS_FT_FI3
Number of Residues	106
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:12652322

Chain	Residue	Details
A	SER146-SER148
A	TYR531-GLN537
A	TYR577-THR581
A	HIS176-GLY196
A	TYR229-THR242
A	TYR277-ALA288
A	GLN318-GLY332
A	ASN362-GLN364
A	LEU398-GLU413
A	ASP439-LYS452
A	ILE490-LEU496

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:12652322, ECO:0007744\|PDB:1NQH

Chain	Residue	Details
A	LEU63
A	SER65
A	ASN72
A	VAL90
A	ALA231
A	THR289
A	ARG497
A	TYR531

site_id	SWS_FT_FI5
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269\|PubMed:12652322

Chain	Residue	Details
A	ASP179
A	GLN191
A	ASP193
A	ASP195
A	TYR229
A	ASP230
A	ASP241

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)