2GU2
Crystal Structure of an Aspartoacylase from Rattus norvegicus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006083 | biological_process | acetate metabolic process |
| A | 0006531 | biological_process | aspartate metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| A | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| A | 0019807 | molecular_function | aspartoacylase activity |
| A | 0022010 | biological_process | central nervous system myelination |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048714 | biological_process | positive regulation of oligodendrocyte differentiation |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006083 | biological_process | acetate metabolic process |
| B | 0006531 | biological_process | aspartate metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| B | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| B | 0019807 | molecular_function | aspartoacylase activity |
| B | 0022010 | biological_process | central nervous system myelination |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048714 | biological_process | positive regulation of oligodendrocyte differentiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 601 |
| Chain | Residue |
| A | HIS20 |
| A | GLU23 |
| A | HIS115 |
| A | HOH748 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 602 |
| Chain | Residue |
| B | HIS20 |
| B | GLU23 |
| B | HIS115 |
| B | HOH733 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 701 |
| Chain | Residue |
| A | LEU74 |
| A | LYS102 |
| A | TYR163 |
| A | HOH836 |
| B | ARG308 |
| B | THR310 |
| A | ASP73 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 702 |
| Chain | Residue |
| A | ARG196 |
| A | LYS199 |
| A | HIS200 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 703 |
| Chain | Residue |
| A | CYS60 |
| A | THR61 |
| A | HOH772 |
| A | HOH779 |
| A | HOH796 |
| A | HOH970 |
| A | HOH989 |
| B | THR61 |
| B | HOH801 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 704 |
| Chain | Residue |
| B | HIS20 |
| B | ARG62 |
| B | ASP67 |
| B | ASN69 |
| B | ARG70 |
| B | TYR287 |
| B | LYS290 |
| B | HOH733 |
| B | HOH926 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 705 |
| Chain | Residue |
| B | ARG196 |
| B | LYS199 |
| B | HIS200 |
| B | HOH920 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P45381","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17194761","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GU2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P45381","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P45381","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
