2GRJ
Crystal structure of Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase) (tm1387) from THERMOTOGA MARITIMA at 2.60 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004140 | molecular_function | dephospho-CoA kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0015937 | biological_process | coenzyme A biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004140 | molecular_function | dephospho-CoA kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0015937 | biological_process | coenzyme A biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004140 | molecular_function | dephospho-CoA kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0015937 | biological_process | coenzyme A biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016740 | molecular_function | transferase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004140 | molecular_function | dephospho-CoA kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0015937 | biological_process | coenzyme A biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016740 | molecular_function | transferase activity |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0004140 | molecular_function | dephospho-CoA kinase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0015937 | biological_process | coenzyme A biosynthetic process |
| E | 0016301 | molecular_function | kinase activity |
| E | 0016740 | molecular_function | transferase activity |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0004140 | molecular_function | dephospho-CoA kinase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0015937 | biological_process | coenzyme A biosynthetic process |
| F | 0016301 | molecular_function | kinase activity |
| F | 0016740 | molecular_function | transferase activity |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0004140 | molecular_function | dephospho-CoA kinase activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0015937 | biological_process | coenzyme A biosynthetic process |
| G | 0016301 | molecular_function | kinase activity |
| G | 0016740 | molecular_function | transferase activity |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0004140 | molecular_function | dephospho-CoA kinase activity |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0015937 | biological_process | coenzyme A biosynthetic process |
| H | 0016301 | molecular_function | kinase activity |
| H | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL H 181 |
| Chain | Residue |
| G | GLU162 |
| H | LEU161 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL E 181 |
| Chain | Residue |
| E | THR160 |
| E | LEU161 |
| F | LEU161 |
| F | GLU162 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 181 |
| Chain | Residue |
| D | LEU161 |
| C | THR160 |
| C | LEU161 |
| D | THR160 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL E 182 |
| Chain | Residue |
| E | HIS27 |
| F | ARG62 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADP A 200 |
| Chain | Residue |
| A | LYS8 |
| A | GLY10 |
| A | THR11 |
| A | GLY12 |
| A | LYS13 |
| A | SER14 |
| A | THR15 |
| A | ARG134 |
| A | ASN157 |
| A | SER159 |
| A | THR160 |
| A | HOH202 |
| B | GLU18 |
| B | ILE19 |
| B | ASN22 |
| B | LEU161 |
| B | GLU165 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE COD A 201 |
| Chain | Residue |
| A | ILE9 |
| A | ASP32 |
| A | HIS36 |
| A | LEU39 |
| A | ARG62 |
| A | VAL69 |
| A | LEU76 |
| A | LEU79 |
| A | GLU80 |
| A | HIS84 |
| A | MSE87 |
| A | ALA107 |
| A | LEU108 |
| A | ARG111 |
| A | ARG141 |
| A | PHE144 |
| A | GLN145 |
| A | HOH202 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ADP B 200 |
| Chain | Residue |
| A | GLU18 |
| A | ILE19 |
| A | ASN22 |
| A | LEU161 |
| A | GLU165 |
| B | GLY10 |
| B | THR11 |
| B | GLY12 |
| B | LYS13 |
| B | SER14 |
| B | THR15 |
| B | ARG134 |
| B | ASN157 |
| B | SER159 |
| B | THR160 |
| B | LEU161 |
| B | HOH202 |
| B | HOH203 |
| site_id | AC8 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE COD B 201 |
| Chain | Residue |
| B | ILE9 |
| B | ASP32 |
| B | HIS36 |
| B | LEU39 |
| B | ARG62 |
| B | VAL69 |
| B | PHE70 |
| B | LEU76 |
| B | LEU79 |
| B | GLU80 |
| B | HIS84 |
| B | MSE87 |
| B | ALA107 |
| B | LEU108 |
| B | ARG111 |
| B | ARG141 |
| B | PHE144 |
| B | GLN145 |
| B | HOH202 |
| site_id | AC9 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP C 200 |
| Chain | Residue |
| D | GLU165 |
| C | GLY10 |
| C | THR11 |
| C | GLY12 |
| C | LYS13 |
| C | SER14 |
| C | THR15 |
| C | ARG134 |
| C | ASN157 |
| C | SER159 |
| C | THR160 |
| C | HOH202 |
| D | GLU18 |
| D | ILE19 |
| D | ASN22 |
| D | LEU161 |
| site_id | BC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE COD C 201 |
| Chain | Residue |
| C | ILE9 |
| C | ASP32 |
| C | HIS36 |
| C | LEU39 |
| C | ARG62 |
| C | VAL69 |
| C | LEU76 |
| C | GLU80 |
| C | HIS84 |
| C | MSE87 |
| C | ALA107 |
| C | LEU108 |
| C | ARG111 |
| C | ARG141 |
| C | PHE144 |
| C | GLN145 |
| C | HOH202 |
| site_id | BC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADP D 200 |
| Chain | Residue |
| C | GLU18 |
| C | ILE19 |
| C | ASN22 |
| C | LEU161 |
| C | GLU165 |
| D | LYS8 |
| D | GLY10 |
| D | THR11 |
| D | GLY12 |
| D | LYS13 |
| D | SER14 |
| D | THR15 |
| D | ARG134 |
| D | ASN157 |
| D | SER159 |
| D | THR160 |
| D | HOH202 |
| site_id | BC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE COD D 201 |
| Chain | Residue |
| D | ILE9 |
| D | ASP32 |
| D | HIS36 |
| D | LEU39 |
| D | ARG62 |
| D | VAL69 |
| D | LEU76 |
| D | LEU79 |
| D | GLU80 |
| D | HIS84 |
| D | MSE87 |
| D | LEU108 |
| D | ARG111 |
| D | ARG141 |
| D | PHE144 |
| D | GLN145 |
| D | HOH202 |
| site_id | BC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADP E 200 |
| Chain | Residue |
| E | GLY10 |
| E | THR11 |
| E | GLY12 |
| E | LYS13 |
| E | SER14 |
| E | THR15 |
| E | ARG134 |
| E | ASN157 |
| E | SER159 |
| E | THR160 |
| E | LEU161 |
| E | HOH202 |
| E | HOH207 |
| F | GLU18 |
| F | ASN22 |
| F | LEU161 |
| F | GLU165 |
| site_id | BC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE COD E 201 |
| Chain | Residue |
| E | ILE9 |
| E | ASP32 |
| E | HIS36 |
| E | LEU39 |
| E | ARG62 |
| E | LEU65 |
| E | ALA66 |
| E | VAL69 |
| E | LEU76 |
| E | LEU79 |
| E | GLU80 |
| E | HIS84 |
| E | LEU108 |
| E | ARG111 |
| E | ARG141 |
| E | PHE144 |
| E | GLN145 |
| E | HOH202 |
| site_id | BC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP F 200 |
| Chain | Residue |
| E | GLU18 |
| E | ILE19 |
| E | LEU161 |
| E | GLU165 |
| F | LYS8 |
| F | GLY10 |
| F | THR11 |
| F | GLY12 |
| F | LYS13 |
| F | SER14 |
| F | THR15 |
| F | ARG134 |
| F | ASN157 |
| F | SER159 |
| F | THR160 |
| F | LEU161 |
| site_id | BC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE COD F 201 |
| Chain | Residue |
| F | ILE9 |
| F | ASP32 |
| F | HIS36 |
| F | LEU39 |
| F | ARG62 |
| F | VAL69 |
| F | LEU76 |
| F | LEU79 |
| F | GLU80 |
| F | HIS84 |
| F | MSE87 |
| F | LEU108 |
| F | ARG111 |
| F | ARG141 |
| F | PHE144 |
| F | GLN145 |
| site_id | BC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP G 200 |
| Chain | Residue |
| G | GLY10 |
| G | GLY12 |
| G | LYS13 |
| G | SER14 |
| G | THR15 |
| G | ARG134 |
| G | ASN157 |
| G | SER159 |
| G | THR160 |
| G | LEU161 |
| G | HOH202 |
| H | GLU18 |
| H | ILE19 |
| H | ASN22 |
| H | LEU161 |
| H | GLU165 |
| site_id | BC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE COD G 201 |
| Chain | Residue |
| G | ILE9 |
| G | ASP32 |
| G | HIS36 |
| G | LEU39 |
| G | ARG62 |
| G | VAL69 |
| G | LEU76 |
| G | LEU79 |
| G | GLU80 |
| G | HIS84 |
| G | MSE87 |
| G | LEU108 |
| G | ARG111 |
| G | ARG141 |
| G | PHE144 |
| G | GLN145 |
| G | HOH202 |
| site_id | CC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADP H 200 |
| Chain | Residue |
| G | GLU18 |
| G | ILE19 |
| G | ASN22 |
| G | LEU161 |
| G | GLU165 |
| H | GLY10 |
| H | THR11 |
| H | GLY12 |
| H | LYS13 |
| H | SER14 |
| H | THR15 |
| H | ARG134 |
| H | ASN157 |
| H | SER159 |
| H | THR160 |
| H | LEU161 |
| H | HOH202 |
| site_id | CC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE COD H 201 |
| Chain | Residue |
| H | ILE9 |
| H | ASP32 |
| H | HIS36 |
| H | LEU39 |
| H | ARG62 |
| H | VAL69 |
| H | PHE70 |
| H | LEU76 |
| H | LEU79 |
| H | GLU80 |
| H | HIS84 |
| H | MSE87 |
| H | LEU108 |
| H | ARG111 |
| H | ARG141 |
| H | PHE144 |
| H | GLN145 |
| H | HOH202 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00376","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
