2GQS
SAICAR Synthetase Complexed with CAIR-Mg2+ and ADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004639 | molecular_function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0009236 | biological_process | cobalamin biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016874 | molecular_function | ligase activity |
| A | 0097216 | molecular_function | guanosine tetraphosphate binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004639 | molecular_function | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0009236 | biological_process | cobalamin biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016874 | molecular_function | ligase activity |
| B | 0097216 | molecular_function | guanosine tetraphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 239 |
| Chain | Residue |
| A | ADP238 |
| A | FMT243 |
| A | HOH244 |
| A | HOH245 |
| A | HOH246 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 240 |
| Chain | Residue |
| A | HOH248 |
| A | HOH249 |
| A | GLU90 |
| A | ASP129 |
| A | MG241 |
| A | C2R242 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 241 |
| Chain | Residue |
| A | GLU90 |
| A | ASP129 |
| A | MG240 |
| A | C2R242 |
| A | FMT243 |
| A | HOH250 |
| A | HOH251 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 239 |
| Chain | Residue |
| B | ADP238 |
| B | FMT243 |
| B | HOH244 |
| B | HOH245 |
| B | HOH246 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 240 |
| Chain | Residue |
| B | GLU90 |
| B | ASP129 |
| B | MG241 |
| B | C2R242 |
| B | HOH248 |
| B | HOH249 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B 241 |
| Chain | Residue |
| B | GLU90 |
| B | ASP129 |
| B | MG240 |
| B | C2R242 |
| B | FMT243 |
| B | HOH250 |
| B | HOH251 |
| site_id | AC7 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADP A 238 |
| Chain | Residue |
| A | TYR8 |
| A | GLY10 |
| A | LYS11 |
| A | ALA12 |
| A | LYS13 |
| A | VAL15 |
| A | LEU24 |
| A | GLN69 |
| A | LYS82 |
| A | LEU84 |
| A | MET86 |
| A | LYS123 |
| A | GLU179 |
| A | ASP191 |
| A | MG239 |
| A | FMT243 |
| A | HOH245 |
| A | HOH246 |
| A | HOH291 |
| A | HOH311 |
| A | HOH328 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE C2R A 242 |
| Chain | Residue |
| A | ASP36 |
| A | GLU90 |
| A | ARG94 |
| A | GLY99 |
| A | SER100 |
| A | ASP129 |
| A | ASP175 |
| A | LYS177 |
| A | ASP196 |
| A | GLY197 |
| A | SER198 |
| A | ARG199 |
| A | ARG215 |
| A | MG240 |
| A | MG241 |
| A | FMT243 |
| A | HOH248 |
| A | HOH249 |
| A | HOH250 |
| A | HOH281 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADP B 238 |
| Chain | Residue |
| B | TYR8 |
| B | GLY10 |
| B | LYS11 |
| B | ALA12 |
| B | LYS13 |
| B | VAL15 |
| B | GLN69 |
| B | LYS82 |
| B | LEU84 |
| B | MET86 |
| B | LYS123 |
| B | GLU179 |
| B | ASP191 |
| B | MG239 |
| B | FMT243 |
| B | HOH244 |
| B | HOH246 |
| site_id | BC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE C2R B 242 |
| Chain | Residue |
| B | ASP175 |
| B | LYS177 |
| B | ASP196 |
| B | GLY197 |
| B | SER198 |
| B | ARG199 |
| B | ARG215 |
| B | MG240 |
| B | MG241 |
| B | FMT243 |
| B | HOH248 |
| B | HOH250 |
| B | HOH264 |
| B | HOH275 |
| B | HOH319 |
| B | GLU90 |
| B | ARG94 |
| B | GLY99 |
| B | SER100 |
| B | ASP129 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE FMT A 243 |
| Chain | Residue |
| A | LYS11 |
| A | GLU90 |
| A | LYS123 |
| A | LYS177 |
| A | GLU179 |
| A | ADP238 |
| A | MG239 |
| A | MG241 |
| A | C2R242 |
| A | HOH244 |
| A | HOH246 |
| site_id | BC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE FMT B 243 |
| Chain | Residue |
| B | LYS11 |
| B | GLU90 |
| B | LYS123 |
| B | LYS177 |
| B | GLU179 |
| B | ADP238 |
| B | MG239 |
| B | MG241 |
| B | C2R242 |
| B | HOH246 |
| B | HOH251 |
Functional Information from PROSITE/UniProt
