2GQ3
mycobacterium tuberculosis malate synthase in complex with magnesium, malate, and coenzyme A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0001968 | molecular_function | fibronectin binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004474 | molecular_function | malate synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005518 | molecular_function | collagen binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006097 | biological_process | glyoxylate cycle |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0009436 | biological_process | glyoxylate catabolic process |
| A | 0009986 | cellular_component | cell surface |
| A | 0015936 | biological_process | coenzyme A metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0042603 | cellular_component | capsule |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043236 | molecular_function | laminin binding |
| A | 0044406 | biological_process | adhesion of symbiont to host |
| A | 0046810 | molecular_function | host cell extracellular matrix binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0120225 | molecular_function | coenzyme A binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0001968 | molecular_function | fibronectin binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004474 | molecular_function | malate synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005518 | molecular_function | collagen binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006097 | biological_process | glyoxylate cycle |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0009436 | biological_process | glyoxylate catabolic process |
| B | 0009986 | cellular_component | cell surface |
| B | 0015936 | biological_process | coenzyme A metabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0042603 | cellular_component | capsule |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043236 | molecular_function | laminin binding |
| B | 0044406 | biological_process | adhesion of symbiont to host |
| B | 0046810 | molecular_function | host cell extracellular matrix binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0120225 | molecular_function | coenzyme A binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1000 |
| Chain | Residue |
| A | GLU434 |
| A | ASP462 |
| A | MLT900 |
| A | HOH2651 |
| A | HOH2652 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1001 |
| Chain | Residue |
| B | HOH2654 |
| B | GLU434 |
| B | ASP462 |
| B | MLT901 |
| B | HOH2653 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1002 |
| Chain | Residue |
| A | HIS374 |
| A | LYS377 |
| A | ASN382 |
| A | GLY383 |
| A | LEU385 |
| A | HOH2801 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B 1003 |
| Chain | Residue |
| B | ASN295 |
| B | HIS374 |
| B | LYS377 |
| B | ASN382 |
| B | GLY383 |
| B | LEU385 |
| B | HOH2802 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE MLT A 900 |
| Chain | Residue |
| A | ARG339 |
| A | GLU434 |
| A | GLY459 |
| A | PHE460 |
| A | LEU461 |
| A | ASP462 |
| A | TRP541 |
| A | ASP633 |
| A | COA800 |
| A | MG1000 |
| A | HOH2035 |
| A | HOH2651 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE MLT B 901 |
| Chain | Residue |
| B | ARG339 |
| B | GLU434 |
| B | GLY459 |
| B | PHE460 |
| B | LEU461 |
| B | ASP462 |
| B | TRP541 |
| B | ASP633 |
| B | MG1001 |
| B | HOH2554 |
| B | HOH2653 |
| B | HOH2654 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE COA A 800 |
| Chain | Residue |
| A | VAL118 |
| A | VAL119 |
| A | ARG125 |
| A | PHE126 |
| A | ASN129 |
| A | ALA130 |
| A | LYS305 |
| A | ARG312 |
| A | PRO543 |
| A | PRO545 |
| A | CYS619 |
| A | LYS621 |
| A | MET631 |
| A | ASP633 |
| A | MLT900 |
| A | HOH2800 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EPE A 5000 |
| Chain | Residue |
| A | LEU122 |
| A | ASN123 |
| A | ASP283 |
| A | LEU286 |
| A | GLN615 |
| A | GLY616 |
| A | ARG718 |
| A | HOH2040 |
| A | HOH2069 |
| A | HOH2760 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EPE B 6000 |
| Chain | Residue |
| B | LEU122 |
| B | ASN123 |
| B | GLN615 |
| B | GLY616 |
| B | ARG718 |
| B | HOH2483 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 37 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Cysteine sulfenic acid (-SOH)","evidences":[{"source":"HAMAP-Rule","id":"MF_00641","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1d8c |
| Chain | Residue | Details |
| A | GLU273 | |
| A | ARG339 | |
| A | ASP633 | |
| A | ASP271 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1d8c |
| Chain | Residue | Details |
| B | GLU273 | |
| B | ARG339 | |
| B | ASP633 | |
| B | ASP271 |
