2GQ3
mycobacterium tuberculosis malate synthase in complex with magnesium, malate, and coenzyme A
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0001968 | molecular_function | fibronectin binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0004474 | molecular_function | malate synthase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005518 | molecular_function | collagen binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006097 | biological_process | glyoxylate cycle |
A | 0006099 | biological_process | tricarboxylic acid cycle |
A | 0009274 | cellular_component | peptidoglycan-based cell wall |
A | 0009436 | biological_process | glyoxylate catabolic process |
A | 0009986 | cellular_component | cell surface |
A | 0015936 | biological_process | coenzyme A metabolic process |
A | 0016740 | molecular_function | transferase activity |
A | 0042603 | cellular_component | capsule |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0043236 | molecular_function | laminin binding |
A | 0044406 | biological_process | adhesion of symbiont to host |
A | 0046810 | molecular_function | host cell extracellular matrix binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0120225 | molecular_function | coenzyme A binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0001968 | molecular_function | fibronectin binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004474 | molecular_function | malate synthase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005518 | molecular_function | collagen binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0006097 | biological_process | glyoxylate cycle |
B | 0006099 | biological_process | tricarboxylic acid cycle |
B | 0009274 | cellular_component | peptidoglycan-based cell wall |
B | 0009436 | biological_process | glyoxylate catabolic process |
B | 0009986 | cellular_component | cell surface |
B | 0015936 | biological_process | coenzyme A metabolic process |
B | 0016740 | molecular_function | transferase activity |
B | 0042603 | cellular_component | capsule |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0043236 | molecular_function | laminin binding |
B | 0044406 | biological_process | adhesion of symbiont to host |
B | 0046810 | molecular_function | host cell extracellular matrix binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0120225 | molecular_function | coenzyme A binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 1000 |
Chain | Residue |
A | GLU434 |
A | ASP462 |
A | MLT900 |
A | HOH2651 |
A | HOH2652 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG B 1001 |
Chain | Residue |
B | HOH2654 |
B | GLU434 |
B | ASP462 |
B | MLT901 |
B | HOH2653 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 1002 |
Chain | Residue |
A | HIS374 |
A | LYS377 |
A | ASN382 |
A | GLY383 |
A | LEU385 |
A | HOH2801 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG B 1003 |
Chain | Residue |
B | ASN295 |
B | HIS374 |
B | LYS377 |
B | ASN382 |
B | GLY383 |
B | LEU385 |
B | HOH2802 |
site_id | AC5 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE MLT A 900 |
Chain | Residue |
A | ARG339 |
A | GLU434 |
A | GLY459 |
A | PHE460 |
A | LEU461 |
A | ASP462 |
A | TRP541 |
A | ASP633 |
A | COA800 |
A | MG1000 |
A | HOH2035 |
A | HOH2651 |
site_id | AC6 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE MLT B 901 |
Chain | Residue |
B | ARG339 |
B | GLU434 |
B | GLY459 |
B | PHE460 |
B | LEU461 |
B | ASP462 |
B | TRP541 |
B | ASP633 |
B | MG1001 |
B | HOH2554 |
B | HOH2653 |
B | HOH2654 |
site_id | AC7 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE COA A 800 |
Chain | Residue |
A | VAL118 |
A | VAL119 |
A | ARG125 |
A | PHE126 |
A | ASN129 |
A | ALA130 |
A | LYS305 |
A | ARG312 |
A | PRO543 |
A | PRO545 |
A | CYS619 |
A | LYS621 |
A | MET631 |
A | ASP633 |
A | MLT900 |
A | HOH2800 |
site_id | AC8 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE EPE A 5000 |
Chain | Residue |
A | LEU122 |
A | ASN123 |
A | ASP283 |
A | LEU286 |
A | GLN615 |
A | GLY616 |
A | ARG718 |
A | HOH2040 |
A | HOH2069 |
A | HOH2760 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EPE B 6000 |
Chain | Residue |
B | LEU122 |
B | ASN123 |
B | GLN615 |
B | GLY616 |
B | ARG718 |
B | HOH2483 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | ARG339 | |
B | ARG339 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor |
Chain | Residue | Details |
A | ASP633 | |
B | ASP633 |
site_id | SWS_FT_FI3 |
Number of Residues | 24 |
Details | BINDING: |
Chain | Residue | Details |
A | VAL118 | |
A | PRO543 | |
A | GLY618 | |
A | ASP633 | |
B | VAL118 | |
B | ARG125 | |
B | SER275 | |
B | LYS305 | |
B | ARG312 | |
B | ARG339 | |
B | GLU434 | |
A | ARG125 | |
B | GLY459 | |
B | ASP462 | |
B | PRO543 | |
B | GLY618 | |
B | ASP633 | |
A | SER275 | |
A | LYS305 | |
A | ARG312 | |
A | ARG339 | |
A | GLU434 | |
A | GLY459 | |
A | ASP462 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Cysteine sulfenic acid (-SOH) => ECO:0000255|HAMAP-Rule:MF_00641 |
Chain | Residue | Details |
A | CYS619 | |
B | CYS619 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1d8c |
Chain | Residue | Details |
A | GLU273 | |
A | ARG339 | |
A | ASP633 | |
A | ASP271 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1d8c |
Chain | Residue | Details |
B | GLU273 | |
B | ARG339 | |
B | ASP633 | |
B | ASP271 |