2GP6
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001666 | biological_process | response to hypoxia |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0030497 | biological_process | fatty acid elongation |
| A | 0071768 | biological_process | mycolic acid biosynthetic process |
| B | 0001666 | biological_process | response to hypoxia |
| B | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0030497 | biological_process | fatty acid elongation |
| B | 0071768 | biological_process | mycolic acid biosynthetic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 |
| Chain | Residue | Details |
| A | CYS170 | |
| A | HIS311 | |
| A | HIS346 | |
| B | CYS170 | |
| B | HIS311 | |
| B | HIS346 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:24809459 |
| Chain | Residue | Details |
| A | THR313 | |
| A | THR315 | |
| B | THR313 | |
| B | THR315 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| A | HIS311 | |
| A | CYS170 | |
| A | HIS346 | |
| A | PHE405 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| B | HIS311 | |
| B | CYS170 | |
| B | HIS346 | |
| B | PHE405 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| A | HIS311 | |
| A | CYS170 | |
| A | PHE403 | |
| A | PHE405 | |
| A | LYS341 | |
| A | HIS346 |
| site_id | CSA4 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| B | HIS311 | |
| B | CYS170 | |
| B | PHE403 | |
| B | PHE405 | |
| B | LYS341 | |
| B | HIS346 |
