2GM8
TenA Homolog/Thi-4 Thiaminase complexed with product 4-amino-5-hydroxymethyl-2-methylpyrimidine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006772 | biological_process | thiamine metabolic process |
| A | 0050334 | molecular_function | thiaminase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006772 | biological_process | thiamine metabolic process |
| B | 0050334 | molecular_function | thiaminase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006772 | biological_process | thiamine metabolic process |
| C | 0050334 | molecular_function | thiaminase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006772 | biological_process | thiamine metabolic process |
| D | 0050334 | molecular_function | thiaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE HMH A 301 |
| Chain | Residue |
| A | ASP43 |
| A | PHE204 |
| A | TYR46 |
| A | LEU47 |
| A | GLU81 |
| A | TYR85 |
| A | CYS134 |
| A | TYR138 |
| A | TYR169 |
| A | GLU201 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HMH B 302 |
| Chain | Residue |
| B | ASP43 |
| B | TYR46 |
| B | LEU47 |
| B | GLU81 |
| B | CYS134 |
| B | TYR138 |
| B | TYR169 |
| B | GLU201 |
| B | PHE204 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE HMH C 303 |
| Chain | Residue |
| C | ASP43 |
| C | TYR46 |
| C | LEU47 |
| C | GLU81 |
| C | CYS134 |
| C | TYR138 |
| C | TYR169 |
| C | GLU201 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HMH D 304 |
| Chain | Residue |
| D | ASP43 |
| D | TYR46 |
| D | LEU47 |
| D | GLU81 |
| D | CYS134 |
| D | TYR138 |
| D | TYR169 |
| D | GLU201 |
| D | HOH314 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 305 |
| Chain | Residue |
| A | SER110 |
| A | GLU203 |
| C | SER110 |
| C | GLU203 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 306 |
| Chain | Residue |
| B | TYR200 |
| B | GLU203 |
| D | SER110 |
| D | GLU203 |
