Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2GLV

Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase(FabZ) mutant(Y100A) from Helicobacter pylori

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006633	biological_process	fatty acid biosynthetic process
A	0009245	biological_process	lipid A biosynthetic process
A	0016020	cellular_component	membrane
A	0016829	molecular_function	lyase activity
A	0016836	molecular_function	hydro-lyase activity
A	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B	0005737	cellular_component	cytoplasm
B	0006633	biological_process	fatty acid biosynthetic process
B	0009245	biological_process	lipid A biosynthetic process
B	0016020	cellular_component	membrane
B	0016829	molecular_function	lyase activity
B	0016836	molecular_function	hydro-lyase activity
B	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
C	0005737	cellular_component	cytoplasm
C	0006633	biological_process	fatty acid biosynthetic process
C	0009245	biological_process	lipid A biosynthetic process
C	0016020	cellular_component	membrane
C	0016829	molecular_function	lyase activity
C	0016836	molecular_function	hydro-lyase activity
C	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
D	0005737	cellular_component	cytoplasm
D	0006633	biological_process	fatty acid biosynthetic process
D	0009245	biological_process	lipid A biosynthetic process
D	0016020	cellular_component	membrane
D	0016829	molecular_function	lyase activity
D	0016836	molecular_function	hydro-lyase activity
D	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
E	0005737	cellular_component	cytoplasm
E	0006633	biological_process	fatty acid biosynthetic process
E	0009245	biological_process	lipid A biosynthetic process
E	0016020	cellular_component	membrane
E	0016829	molecular_function	lyase activity
E	0016836	molecular_function	hydro-lyase activity
E	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
F	0005737	cellular_component	cytoplasm
F	0006633	biological_process	fatty acid biosynthetic process
F	0009245	biological_process	lipid A biosynthetic process
F	0016020	cellular_component	membrane
F	0016829	molecular_function	lyase activity
F	0016836	molecular_function	hydro-lyase activity
F	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
G	0005737	cellular_component	cytoplasm
G	0006633	biological_process	fatty acid biosynthetic process
G	0009245	biological_process	lipid A biosynthetic process
G	0016020	cellular_component	membrane
G	0016829	molecular_function	lyase activity
G	0016836	molecular_function	hydro-lyase activity
G	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
H	0005737	cellular_component	cytoplasm
H	0006633	biological_process	fatty acid biosynthetic process
H	0009245	biological_process	lipid A biosynthetic process
H	0016020	cellular_component	membrane
H	0016829	molecular_function	lyase activity
H	0016836	molecular_function	hydro-lyase activity
H	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
I	0005737	cellular_component	cytoplasm
I	0006633	biological_process	fatty acid biosynthetic process
I	0009245	biological_process	lipid A biosynthetic process
I	0016020	cellular_component	membrane
I	0016829	molecular_function	lyase activity
I	0016836	molecular_function	hydro-lyase activity
I	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
J	0005737	cellular_component	cytoplasm
J	0006633	biological_process	fatty acid biosynthetic process
J	0009245	biological_process	lipid A biosynthetic process
J	0016020	cellular_component	membrane
J	0016829	molecular_function	lyase activity
J	0016836	molecular_function	hydro-lyase activity
J	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
K	0005737	cellular_component	cytoplasm
K	0006633	biological_process	fatty acid biosynthetic process
K	0009245	biological_process	lipid A biosynthetic process
K	0016020	cellular_component	membrane
K	0016829	molecular_function	lyase activity
K	0016836	molecular_function	hydro-lyase activity
K	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
L	0005737	cellular_component	cytoplasm
L	0006633	biological_process	fatty acid biosynthetic process
L	0009245	biological_process	lipid A biosynthetic process
L	0016020	cellular_component	membrane
L	0016829	molecular_function	lyase activity
L	0016836	molecular_function	hydro-lyase activity
L	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 1001

Chain	Residue
A	PHE101
B	HIS58
B	GLY67

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL I 1002

Chain	Residue
I	GLY67

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 1003

Chain	Residue
E	PHE101
F	GLY67

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL F 1004

Chain	Residue
F	HOH1019
E	GLY67
F	PHE101
F	HOH1006

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL K 1005

Chain	Residue
K	HIS58
K	GLY67
L	PHE101

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL K 1006

Chain	Residue
K	PHE101
L	GLY67

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL I 1007

Chain	Residue
I	PHE101
I	HOH1008
I	HOH1020

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G 1008

Chain	Residue
G	PHE101
H	GLY67

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL G 1009

Chain	Residue
G	GLY67

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1010

Chain	Residue
A	GLY67

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 1011

Chain	Residue
C	GLY67
D	PHE101

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 1012

Chain	Residue
C	PHE101
D	HIS58
D	GLY67

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00406

Chain	Residue	Details
A	HIS58
J	HIS58
K	HIS58
L	HIS58
B	HIS58
C	HIS58
D	HIS58
E	HIS58
F	HIS58
G	HIS58
H	HIS58
I	HIS58

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
F	GLU72

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
I	GLU72

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
G	GLU72

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
L	GLU72

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
A	GLU72

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
J	GLU72

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
K	GLU72

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
E	GLU72

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
B	GLU72

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
H	GLU72

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
C	GLU72

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
D	GLU72

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)