Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2GLP

Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase(FabZ) from Helicobacter pylori complexed with compound 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006633	biological_process	fatty acid biosynthetic process
A	0009245	biological_process	lipid A biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016836	molecular_function	hydro-lyase activity
A	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B	0005737	cellular_component	cytoplasm
B	0006633	biological_process	fatty acid biosynthetic process
B	0009245	biological_process	lipid A biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016836	molecular_function	hydro-lyase activity
B	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
C	0005737	cellular_component	cytoplasm
C	0006633	biological_process	fatty acid biosynthetic process
C	0009245	biological_process	lipid A biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016836	molecular_function	hydro-lyase activity
C	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
D	0005737	cellular_component	cytoplasm
D	0006633	biological_process	fatty acid biosynthetic process
D	0009245	biological_process	lipid A biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016836	molecular_function	hydro-lyase activity
D	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
E	0005737	cellular_component	cytoplasm
E	0006633	biological_process	fatty acid biosynthetic process
E	0009245	biological_process	lipid A biosynthetic process
E	0016829	molecular_function	lyase activity
E	0016836	molecular_function	hydro-lyase activity
E	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
F	0005737	cellular_component	cytoplasm
F	0006633	biological_process	fatty acid biosynthetic process
F	0009245	biological_process	lipid A biosynthetic process
F	0016829	molecular_function	lyase activity
F	0016836	molecular_function	hydro-lyase activity
F	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1001

Chain	Residue
A	HIS58
A	GLY67
B	HOH2096

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 1002

Chain	Residue
A	HOH3007
A	HOH3015
A	HOH3094
B	GLY67

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 1003

Chain	Residue
C	GLY67
D	HOH1045

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 1004

Chain	Residue
D	HIS58
D	PRO66
D	GLY67

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 1005

Chain	Residue
E	GLY67
F	HOH2027

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL F 1006

Chain	Residue
E	HOH1012
E	HOH1025
F	GLY67

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BEN A 2001

Chain	Residue
A	GLN9
A	GLN11
A	PHE12
A	HOH3038

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE BEN A 2004

Chain	Residue
A	ILE20
A	LEU21
A	PRO22
A	HIS23
A	PHE83
A	ALA94
A	LYS97
A	ILE98
A	VAL99
A	ARG158
A	HOH3067

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BEN A 2005

Chain	Residue
A	GLN40
A	GLU124
A	VAL125
A	HOH3061
E	THR138
E	GLU148
E	HOH1050
E	HOH1098

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BEN A 2007

Chain	Residue
A	THR138
A	GLU148
A	HOH3095
A	HOH3100
E	GLU124
E	VAL125
E	LEU126

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BEN A 2009

Chain	Residue
A	MET131
A	MET154
A	ILE155
F	LEU86
F	ILE93

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE BDE A 3001

Chain	Residue
A	PHE59
A	LYS62
A	ILE64
A	ILE111
A	PRO112
B	ILE98
B	TYR100
B	GLU159
B	HOH2095

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BEN B 2006

Chain	Residue
B	ILE20
B	LEU21
B	PRO22
B	HIS23
B	PHE83
B	LYS97
B	VAL99

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BEN B 2008

Chain	Residue
B	TRP87
B	GLY88
B	HOH2098
E	LEU86
E	TRP87
E	GLY130
E	MET131

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BEN C 2010

Chain	Residue
C	ALA38
C	THR84
C	SER85
C	LEU86
C	TRP87
C	GLY88
D	GLN40
D	HOH1082

site_id	BC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE BDE C 3002

Chain	Residue
C	ILE20
C	LEU21
C	PRO22
C	PHE83
C	ALA94
C	LYS97
C	ILE98
C	VAL99
C	HOH3069
C	HOH3070
D	LYS62
D	ILE64

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BEN F 2002

Chain	Residue
F	MET27
F	HOH2029
F	HOH2055
B	HOH2050
E	PRO26
E	ASP53
F	PRO26

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BEN F 2003

Chain	Residue
F	LYS41
F	HIS122
F	LEU123
F	GLU124

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00406

Chain	Residue	Details
A	HIS58
B	HIS58
C	HIS58
D	HIS58
E	HIS58
F	HIS58

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
F	GLU72

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
A	GLU72

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
D	GLU72

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
C	GLU72

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
E	GLU72

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1mka

Chain	Residue	Details
B	GLU72

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)