2GJK

Structural and functional insights into the human Upf1 helicase core

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 1000

Chain	Residue
A	THR499
A	GLU637
A	ANP990

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site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ANP A 990

Chain	Residue
A	GLY495
A	THR496
A	GLY497
A	LYS498
A	THR499
A	VAL500
A	LYS533
A	GLN665
A	TYR702
A	ARG703
A	GLY831
A	GLU833
A	ARG865
A	MG1000
A	HOH3
A	HOH23
A	HOH85
A	ASP470
A	ASN472
A	GLN475

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:21419344

Chain	Residue	Details
A	PRO486
A	ALA676
A	SER713
A	ALA844

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0007744|PDB:2GJK

Chain	Residue	Details
A	VAL506

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	ILE565

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