2GIL

Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1201

Chain	Residue
A	THR27
A	THR45
A	GTP1200
A	HOH1304
A	HOH1305

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 2201

Chain	Residue
B	HOH2336
B	THR27
B	THR45
B	GTP2200
B	HOH2335

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 3201

Chain	Residue
C	THR27
C	THR45
C	GTP3200
C	HOH3331
C	HOH3332

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 4201

Chain	Residue
D	THR27
D	THR45
D	GTP4200
D	HOH4329
D	HOH4330

---

site_id	AC5
Number of Residues	27
Details	BINDING SITE FOR RESIDUE GTP A 1200

Chain	Residue
A	GLN22
A	SER23
A	VAL24
A	GLY25
A	LYS26
A	THR27
A	SER28
A	PHE38
A	ASP39
A	ASN40
A	TYR42
A	ALA44
A	THR45
A	GLY71
A	ASN126
A	LYS127
A	ASP129
A	LEU130
A	SER156
A	ALA157
A	LYS158
A	MG1201
A	HOH1211
A	HOH1222
A	HOH1225
A	HOH1304
A	HOH1305

---

site_id	AC6
Number of Residues	30
Details	BINDING SITE FOR RESIDUE GTP B 2200

Chain	Residue
B	GLN22
B	SER23
B	VAL24
B	GLY25
B	LYS26
B	THR27
B	SER28
B	PHE38
B	ASP39
B	ASN40
B	TYR42
B	THR45
B	GLY71
B	ASN126
B	LYS127
B	ASP129
B	LEU130
B	SER156
B	ALA157
B	LYS158
B	MG2201
B	HOH2203
B	HOH2215
B	HOH2233
B	HOH2261
B	HOH2303
B	HOH2304
B	HOH2335
B	HOH2336
D	TYR161

---

site_id	AC7
Number of Residues	29
Details	BINDING SITE FOR RESIDUE GTP C 3200

Chain	Residue
C	HOH3207
C	HOH3212
C	HOH3222
C	HOH3242
C	HOH3243
C	HOH3331
C	HOH3332
C	GLN22
C	SER23
C	VAL24
C	GLY25
C	LYS26
C	THR27
C	SER28
C	PHE38
C	ASP39
C	ASN40
C	TYR42
C	ALA44
C	THR45
C	GLY71
C	ASN126
C	LYS127
C	ASP129
C	LEU130
C	SER156
C	ALA157
C	LYS158
C	MG3201

---

site_id	AC8
Number of Residues	29
Details	BINDING SITE FOR RESIDUE GTP D 4200

Chain	Residue
B	TYR161
D	GLN22
D	SER23
D	VAL24
D	GLY25
D	LYS26
D	THR27
D	SER28
D	PHE38
D	ASP39
D	ASN40
D	TYR42
D	THR45
D	GLY71
D	ASN126
D	LYS127
D	ASP129
D	LEU130
D	SER156
D	ALA157
D	LYS158
D	MG4201
D	HOH4205
D	HOH4224
D	HOH4229
D	HOH4261
D	HOH4329
D	HOH4330
D	HOH4334

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"19141279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CWZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	76
Details	Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"19141279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CWZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16332443","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18243103","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19141279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GIL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CWZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16332443","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18243103","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GIL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BBP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16332443","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18243103","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19141279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YZQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GIL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CWZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16332443","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19141279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GIL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CWZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19141279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CWZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"O-AMP-tyrosine; by Legionella DrrA","evidences":[{"source":"PubMed","id":"21822290","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN72

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	GLN72

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	GLN72

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
D	GLN72

---