2GF0

The crystal structure of the human DiRas1 GTPase in the inactive GDP bound state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
A	0019003	molecular_function	GDP binding
A	0043406	biological_process	positive regulation of MAP kinase activity
A	0051019	molecular_function	mitogen-activated protein kinase binding
B	0000166	molecular_function	nucleotide binding
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0016020	cellular_component	membrane
B	0019003	molecular_function	GDP binding
B	0043406	biological_process	positive regulation of MAP kinase activity
B	0051019	molecular_function	mitogen-activated protein kinase binding
C	0000166	molecular_function	nucleotide binding
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005886	cellular_component	plasma membrane
C	0007165	biological_process	signal transduction
C	0016020	cellular_component	membrane
C	0019003	molecular_function	GDP binding
C	0043406	biological_process	positive regulation of MAP kinase activity
C	0051019	molecular_function	mitogen-activated protein kinase binding
D	0000166	molecular_function	nucleotide binding
D	0003924	molecular_function	GTPase activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005886	cellular_component	plasma membrane
D	0007165	biological_process	signal transduction
D	0016020	cellular_component	membrane
D	0019003	molecular_function	GDP binding
D	0043406	biological_process	positive regulation of MAP kinase activity
D	0051019	molecular_function	mitogen-activated protein kinase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 803

Chain	Residue
A	SER21
A	GDP801
A	HOH817
A	HOH858
A	HOH863
A	HOH945

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 903

Chain	Residue
B	HOH958
B	HOH1024
B	HOH1041
B	SER21
B	GDP901
B	HOH914

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG C 1003

Chain	Residue
C	SER21
C	GDP1001
C	HOH1014
C	HOH1050
D	GLU141
D	HOH1142
D	HOH1144

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG D 1103

Chain	Residue
C	GLU141
D	SER21
D	GDP1101
D	HOH1111
D	HOH1113
D	HOH1235
D	HOH1236

---

site_id	AC5
Number of Residues	23
Details	BINDING SITE FOR RESIDUE GDP A 801

Chain	Residue
A	GLY17
A	VAL18
A	GLY19
A	LYS20
A	SER21
A	SER22
A	ARG33
A	ASN121
A	LYS122
A	ASP124
A	GLU125
A	SER150
A	ALA151
A	LYS152
A	MG803
A	HOH828
A	HOH858
A	HOH859
A	HOH863
A	HOH867
A	HOH893
A	HOH945
D	HOH1173

---

site_id	AC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE GDP B 901

Chain	Residue
B	GLY17
B	VAL18
B	GLY19
B	LYS20
B	SER21
B	SER22
B	ARG33
B	ASN121
B	LYS122
B	ASP124
B	GLU125
B	SER150
B	ALA151
B	LYS152
B	MG903
B	HOH926
B	HOH958
B	HOH974
B	HOH989
B	HOH1024
B	HOH1026
B	HOH1041

---

site_id	AC7
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GDP C 1001

Chain	Residue
C	ALA15
C	GLY17
C	VAL18
C	GLY19
C	LYS20
C	SER21
C	SER22
C	PHE32
C	ARG33
C	ASP34
C	ASN121
C	LYS122
C	ASP124
C	GLU125
C	SER150
C	ALA151
C	LYS152
C	MG1003
C	HOH1014
C	HOH1050
C	HOH1057
C	HOH1103
C	HOH1132
C	HOH1138
D	HOH1142

---

site_id	AC8
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GDP D 1101

Chain	Residue
D	GLY19
D	LYS20
D	SER21
D	SER22
D	PHE32
D	ARG33
D	ASP34
D	ASN121
D	LYS122
D	ASP124
D	GLU125
D	SER150
D	ALA151
D	LYS152
D	MG1103
D	HOH1111
D	HOH1113
D	HOH1213
D	HOH1235
D	HOH1237
D	HOH1244
D	HOH1246
D	ALA15
D	GLY17
D	VAL18

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305|Ref.7, ECO:0007744|PDB:2GF0

Chain	Residue	Details
A	GLY17
D	GLY17
D	ASN121
D	ALA151
A	ASN121
A	ALA151
B	GLY17
B	ASN121
B	ALA151
C	GLY17
C	ASN121
C	ALA151

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q96HU8

Chain	Residue	Details
A	ARG33
A	ASP61
B	ARG33
B	ASP61
C	ARG33
C	ASP61
D	ARG33
D	ASP61

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Cysteine methyl ester => ECO:0000255

Chain	Residue	Details
A	CYS195
B	CYS195
C	CYS195
D	CYS195

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	LIPID: S-geranylgeranyl cysteine => ECO:0000250

Chain	Residue	Details
A	CYS195
B	CYS195
C	CYS195
D	CYS195

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	SER65

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	SER65

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	SER65

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site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
D	SER65

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