2GF0
The crystal structure of the human DiRas1 GTPase in the inactive GDP bound state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| A | 0016020 | cellular_component | membrane |
| A | 0043406 | biological_process | positive regulation of MAP kinase activity |
| A | 0051019 | molecular_function | mitogen-activated protein kinase binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007264 | biological_process | small GTPase-mediated signal transduction |
| B | 0016020 | cellular_component | membrane |
| B | 0043406 | biological_process | positive regulation of MAP kinase activity |
| B | 0051019 | molecular_function | mitogen-activated protein kinase binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0007165 | biological_process | signal transduction |
| C | 0007264 | biological_process | small GTPase-mediated signal transduction |
| C | 0016020 | cellular_component | membrane |
| C | 0043406 | biological_process | positive regulation of MAP kinase activity |
| C | 0051019 | molecular_function | mitogen-activated protein kinase binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0007165 | biological_process | signal transduction |
| D | 0007264 | biological_process | small GTPase-mediated signal transduction |
| D | 0016020 | cellular_component | membrane |
| D | 0043406 | biological_process | positive regulation of MAP kinase activity |
| D | 0051019 | molecular_function | mitogen-activated protein kinase binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 803 |
| Chain | Residue |
| A | SER21 |
| A | GDP801 |
| A | HOH817 |
| A | HOH858 |
| A | HOH863 |
| A | HOH945 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 903 |
| Chain | Residue |
| B | HOH958 |
| B | HOH1024 |
| B | HOH1041 |
| B | SER21 |
| B | GDP901 |
| B | HOH914 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG C 1003 |
| Chain | Residue |
| C | SER21 |
| C | GDP1001 |
| C | HOH1014 |
| C | HOH1050 |
| D | GLU141 |
| D | HOH1142 |
| D | HOH1144 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG D 1103 |
| Chain | Residue |
| C | GLU141 |
| D | SER21 |
| D | GDP1101 |
| D | HOH1111 |
| D | HOH1113 |
| D | HOH1235 |
| D | HOH1236 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE GDP A 801 |
| Chain | Residue |
| A | GLY17 |
| A | VAL18 |
| A | GLY19 |
| A | LYS20 |
| A | SER21 |
| A | SER22 |
| A | ARG33 |
| A | ASN121 |
| A | LYS122 |
| A | ASP124 |
| A | GLU125 |
| A | SER150 |
| A | ALA151 |
| A | LYS152 |
| A | MG803 |
| A | HOH828 |
| A | HOH858 |
| A | HOH859 |
| A | HOH863 |
| A | HOH867 |
| A | HOH893 |
| A | HOH945 |
| D | HOH1173 |
| site_id | AC6 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GDP B 901 |
| Chain | Residue |
| B | GLY17 |
| B | VAL18 |
| B | GLY19 |
| B | LYS20 |
| B | SER21 |
| B | SER22 |
| B | ARG33 |
| B | ASN121 |
| B | LYS122 |
| B | ASP124 |
| B | GLU125 |
| B | SER150 |
| B | ALA151 |
| B | LYS152 |
| B | MG903 |
| B | HOH926 |
| B | HOH958 |
| B | HOH974 |
| B | HOH989 |
| B | HOH1024 |
| B | HOH1026 |
| B | HOH1041 |
| site_id | AC7 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE GDP C 1001 |
| Chain | Residue |
| C | ALA15 |
| C | GLY17 |
| C | VAL18 |
| C | GLY19 |
| C | LYS20 |
| C | SER21 |
| C | SER22 |
| C | PHE32 |
| C | ARG33 |
| C | ASP34 |
| C | ASN121 |
| C | LYS122 |
| C | ASP124 |
| C | GLU125 |
| C | SER150 |
| C | ALA151 |
| C | LYS152 |
| C | MG1003 |
| C | HOH1014 |
| C | HOH1050 |
| C | HOH1057 |
| C | HOH1103 |
| C | HOH1132 |
| C | HOH1138 |
| D | HOH1142 |
| site_id | AC8 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE GDP D 1101 |
| Chain | Residue |
| D | GLY19 |
| D | LYS20 |
| D | SER21 |
| D | SER22 |
| D | PHE32 |
| D | ARG33 |
| D | ASP34 |
| D | ASN121 |
| D | LYS122 |
| D | ASP124 |
| D | GLU125 |
| D | SER150 |
| D | ALA151 |
| D | LYS152 |
| D | MG1103 |
| D | HOH1111 |
| D | HOH1113 |
| D | HOH1213 |
| D | HOH1235 |
| D | HOH1237 |
| D | HOH1244 |
| D | HOH1246 |
| D | ALA15 |
| D | GLY17 |
| D | VAL18 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 32 |
| Details | Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"MAR-2006","submissionDatabase":"PDB data bank","title":"The crystal structure of the human DiRas1 GTPase in the inactive GDP bound state.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"2GF0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q96HU8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | SER65 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | SER65 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| C | SER65 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| D | SER65 |
