2GDZ
Crystal structure of 15-hydroxyprostaglandin dehydrogenase type1, complexed with NAD+
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001822 | biological_process | kidney development |
A | 0004957 | molecular_function | prostaglandin E receptor activity |
A | 0005615 | cellular_component | extracellular space |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006693 | biological_process | prostaglandin metabolic process |
A | 0007179 | biological_process | transforming growth factor beta receptor signaling pathway |
A | 0007565 | biological_process | female pregnancy |
A | 0007567 | biological_process | parturition |
A | 0016323 | cellular_component | basolateral plasma membrane |
A | 0016404 | molecular_function | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0019372 | biological_process | lipoxygenase pathway |
A | 0030728 | biological_process | ovulation |
A | 0032355 | biological_process | response to estradiol |
A | 0032496 | biological_process | response to lipopolysaccharide |
A | 0042802 | molecular_function | identical protein binding |
A | 0043065 | biological_process | positive regulation of apoptotic process |
A | 0045471 | biological_process | response to ethanol |
A | 0045786 | biological_process | negative regulation of cell cycle |
A | 0051287 | molecular_function | NAD binding |
A | 0070062 | cellular_component | extracellular exosome |
A | 0070403 | molecular_function | NAD+ binding |
A | 0070493 | biological_process | thrombin-activated receptor signaling pathway |
A | 0097070 | biological_process | ductus arteriosus closure |
A | 1904707 | biological_process | positive regulation of vascular associated smooth muscle cell proliferation |
A | 1905828 | biological_process | regulation of prostaglandin catabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 32 |
Details | BINDING SITE FOR RESIDUE NAD A 300 |
Chain | Residue |
A | GLY12 |
A | ASN91 |
A | ALA92 |
A | GLY93 |
A | VAL94 |
A | ILE106 |
A | SER137 |
A | SER138 |
A | TYR151 |
A | LYS155 |
A | PRO183 |
A | GLN15 |
A | GLY184 |
A | PHE185 |
A | VAL186 |
A | THR188 |
A | ALA189 |
A | ILE190 |
A | HOH304 |
A | HOH313 |
A | HOH325 |
A | HOH378 |
A | GLY16 |
A | HOH383 |
A | HOH434 |
A | HOH441 |
A | ILE17 |
A | ASP36 |
A | TRP37 |
A | CYS63 |
A | ASP64 |
A | VAL65 |
Functional Information from PROSITE/UniProt
site_id | PS00061 |
Number of Residues | 29 |
Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SlaglmpvaqQpvYCASKHGIvGFTrSAA |
Chain | Residue | Details |
A | SER138-ALA166 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | TYR151 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21072165 |
Chain | Residue | Details |
A | GLY12 | |
A | ASP36 | |
A | CYS63 | |
A | ASN91 | |
A | TYR151 | |
A | VAL186 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000305 |
Chain | Residue | Details |
A | SER138 | |
A | GLN148 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1ybv |
Chain | Residue | Details |
A | LYS155 | |
A | ASN107 | |
A | SER138 | |
A | TYR151 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ybv |
Chain | Residue | Details |
A | LYS155 | |
A | GLN148 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ybv |
Chain | Residue | Details |
A | LYS155 | |
A | TYR151 |