2GD7
The Structure of the Cyclin T-binding domain of Hexim1 reveals the molecular basis for regulation of transcription elongation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0004861 | molecular_function | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0017069 | molecular_function | snRNA binding |
| B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| B | 0004861 | molecular_function | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0017069 | molecular_function | snRNA binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 56 |
| Details | Region: {"description":"Mediates interaction with CCNT1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 90 |
| Details | Region: {"description":"Required for inhibition of ESR1-dependent transcription"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 132 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8R409","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
