2GD6
The 1,1-proton transfer reaction mechanism by alpha-methylacyl-CoA racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0006629 | biological_process | lipid metabolic process |
A | 0006637 | biological_process | acyl-CoA metabolic process |
A | 0008111 | molecular_function | alpha-methylacyl-CoA racemase activity |
A | 0016853 | molecular_function | isomerase activity |
A | 0042803 | molecular_function | protein homodimerization activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0006629 | biological_process | lipid metabolic process |
B | 0006637 | biological_process | acyl-CoA metabolic process |
B | 0008111 | molecular_function | alpha-methylacyl-CoA racemase activity |
B | 0016853 | molecular_function | isomerase activity |
B | 0042803 | molecular_function | protein homodimerization activity |
C | 0003824 | molecular_function | catalytic activity |
C | 0006629 | biological_process | lipid metabolic process |
C | 0006637 | biological_process | acyl-CoA metabolic process |
C | 0008111 | molecular_function | alpha-methylacyl-CoA racemase activity |
C | 0016853 | molecular_function | isomerase activity |
C | 0042803 | molecular_function | protein homodimerization activity |
D | 0003824 | molecular_function | catalytic activity |
D | 0006629 | biological_process | lipid metabolic process |
D | 0006637 | biological_process | acyl-CoA metabolic process |
D | 0008111 | molecular_function | alpha-methylacyl-CoA racemase activity |
D | 0016853 | molecular_function | isomerase activity |
D | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE ACO A 751 |
Chain | Residue |
A | ILE16 |
A | ARG85 |
A | VAL88 |
A | ARG91 |
A | GLY125 |
A | HIS126 |
A | TYR130 |
A | ASP156 |
A | MET188 |
A | HOH1392 |
A | HOH1456 |
A | PRO18 |
A | HOH1472 |
A | ARG38 |
A | ALA59 |
A | ASP60 |
A | LEU61 |
A | LYS62 |
A | GLY83 |
A | TYR84 |
site_id | AC2 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE ACO B 752 |
Chain | Residue |
A | HOH1461 |
B | ILE16 |
B | GLY17 |
B | ARG38 |
B | ALA59 |
B | ASP60 |
B | LEU61 |
B | LYS62 |
B | GLY83 |
B | TYR84 |
B | ARG85 |
B | VAL88 |
B | ARG91 |
B | LEU92 |
B | GLY125 |
B | HIS126 |
B | TYR130 |
B | ASP156 |
B | MET188 |
B | HOH771 |
B | HOH889 |
B | HOH934 |
site_id | AC3 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE ACO C 753 |
Chain | Residue |
C | ARG38 |
C | ALA59 |
C | ASP60 |
C | LEU61 |
C | LYS62 |
C | GLY83 |
C | TYR84 |
C | ARG85 |
C | VAL88 |
C | ARG91 |
C | LEU92 |
C | GLY113 |
C | GLY125 |
C | HIS126 |
C | ASP127 |
C | TYR130 |
C | ASP156 |
C | MET188 |
C | GOL1302 |
site_id | AC4 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE ACO D 754 |
Chain | Residue |
D | ALA59 |
D | ASP60 |
D | LEU61 |
D | LYS62 |
D | GLY83 |
D | TYR84 |
D | ARG85 |
D | VAL88 |
D | ARG91 |
D | LEU92 |
D | GLY113 |
D | GLY125 |
D | HIS126 |
D | TYR130 |
D | ASP156 |
D | HOH826 |
D | HOH927 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 1301 |
Chain | Residue |
A | THR209 |
A | ASP210 |
B | THR209 |
B | ASP210 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL C 1302 |
Chain | Residue |
C | ILE16 |
C | HIS126 |
C | ASP127 |
C | ASN152 |
C | ASP156 |
C | ACO753 |
D | TYR224 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:17320106, ECO:0000305|PubMed:22360758 |
Chain | Residue | Details |
A | HIS126 | |
B | HIS126 | |
C | HIS126 | |
D | HIS126 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:17320106, ECO:0000305|PubMed:22360758 |
Chain | Residue | Details |
A | ASP156 | |
B | ASP156 | |
C | ASP156 | |
D | ASP156 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17320106, ECO:0000269|PubMed:22360758 |
Chain | Residue | Details |
A | ARG38 | |
B | GLY125 | |
C | ARG38 | |
C | ALA59 | |
C | GLY83 | |
C | ARG91 | |
C | GLY125 | |
D | ARG38 | |
D | ALA59 | |
D | GLY83 | |
D | ARG91 | |
A | ALA59 | |
D | GLY125 | |
A | GLY83 | |
A | ARG91 | |
A | GLY125 | |
B | ARG38 | |
B | ALA59 | |
B | GLY83 | |
B | ARG91 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1xvt |
Chain | Residue | Details |
A | ASP156 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1xvt |
Chain | Residue | Details |
B | ASP156 |
site_id | CSA3 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1xvt |
Chain | Residue | Details |
C | ASP156 |
site_id | CSA4 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1xvt |
Chain | Residue | Details |
D | ASP156 |