2GD6
The 1,1-proton transfer reaction mechanism by alpha-methylacyl-CoA racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006637 | biological_process | acyl-CoA metabolic process |
| A | 0008111 | molecular_function | alpha-methylacyl-CoA racemase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006637 | biological_process | acyl-CoA metabolic process |
| B | 0008111 | molecular_function | alpha-methylacyl-CoA racemase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0042803 | molecular_function | protein homodimerization activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0006637 | biological_process | acyl-CoA metabolic process |
| C | 0008111 | molecular_function | alpha-methylacyl-CoA racemase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0042803 | molecular_function | protein homodimerization activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0006629 | biological_process | lipid metabolic process |
| D | 0006637 | biological_process | acyl-CoA metabolic process |
| D | 0008111 | molecular_function | alpha-methylacyl-CoA racemase activity |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ACO A 751 |
| Chain | Residue |
| A | ILE16 |
| A | ARG85 |
| A | VAL88 |
| A | ARG91 |
| A | GLY125 |
| A | HIS126 |
| A | TYR130 |
| A | ASP156 |
| A | MET188 |
| A | HOH1392 |
| A | HOH1456 |
| A | PRO18 |
| A | HOH1472 |
| A | ARG38 |
| A | ALA59 |
| A | ASP60 |
| A | LEU61 |
| A | LYS62 |
| A | GLY83 |
| A | TYR84 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ACO B 752 |
| Chain | Residue |
| A | HOH1461 |
| B | ILE16 |
| B | GLY17 |
| B | ARG38 |
| B | ALA59 |
| B | ASP60 |
| B | LEU61 |
| B | LYS62 |
| B | GLY83 |
| B | TYR84 |
| B | ARG85 |
| B | VAL88 |
| B | ARG91 |
| B | LEU92 |
| B | GLY125 |
| B | HIS126 |
| B | TYR130 |
| B | ASP156 |
| B | MET188 |
| B | HOH771 |
| B | HOH889 |
| B | HOH934 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ACO C 753 |
| Chain | Residue |
| C | ARG38 |
| C | ALA59 |
| C | ASP60 |
| C | LEU61 |
| C | LYS62 |
| C | GLY83 |
| C | TYR84 |
| C | ARG85 |
| C | VAL88 |
| C | ARG91 |
| C | LEU92 |
| C | GLY113 |
| C | GLY125 |
| C | HIS126 |
| C | ASP127 |
| C | TYR130 |
| C | ASP156 |
| C | MET188 |
| C | GOL1302 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ACO D 754 |
| Chain | Residue |
| D | ALA59 |
| D | ASP60 |
| D | LEU61 |
| D | LYS62 |
| D | GLY83 |
| D | TYR84 |
| D | ARG85 |
| D | VAL88 |
| D | ARG91 |
| D | LEU92 |
| D | GLY113 |
| D | GLY125 |
| D | HIS126 |
| D | TYR130 |
| D | ASP156 |
| D | HOH826 |
| D | HOH927 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1301 |
| Chain | Residue |
| A | THR209 |
| A | ASP210 |
| B | THR209 |
| B | ASP210 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 1302 |
| Chain | Residue |
| C | ILE16 |
| C | HIS126 |
| C | ASP127 |
| C | ASN152 |
| C | ASP156 |
| C | ACO753 |
| D | TYR224 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17320106","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22360758","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"17320106","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22360758","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17320106","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22360758","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1xvt |
| Chain | Residue | Details |
| A | ASP156 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1xvt |
| Chain | Residue | Details |
| B | ASP156 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1xvt |
| Chain | Residue | Details |
| C | ASP156 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1xvt |
| Chain | Residue | Details |
| D | ASP156 |
