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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2GD4

Crystal Structure of the Antithrombin-S195A Factor Xa-Pentasaccharide Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004867	molecular_function	serine-type endopeptidase inhibitor activity
C	0005615	cellular_component	extracellular space
C	0030193	biological_process	regulation of blood coagulation
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis
I	0004867	molecular_function	serine-type endopeptidase inhibitor activity
I	0005615	cellular_component	extracellular space
I	0030193	biological_process	regulation of blood coagulation

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
H	LEU53-CYS58

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. FKANRPFLVfI

Chain	Residue	Details
I	PHE402-ILE412

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CsCarGYtladngkaC

Chain	Residue	Details
L	CYS109-CYS124

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
I	TRP49
I	ARG129
I	ARG145
C	TRP49
C	ARG129
C	ARG145

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Reactive bond => ECO:0000269\|PubMed:7238875

Chain	Residue	Details
I	ARG393
C	ARG393

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by FAM20C => ECO:0000269\|PubMed:26091039

Chain	Residue	Details
I	THR31
C	THR31

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269\|PubMed:26091039, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
I	SER36
C	SER36

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:14760718, ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:19159218, ECO:0000269\|Ref.10

Chain	Residue	Details
I	ASN96
C	ASN96

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|Ref.10

Chain	Residue	Details
I	ASN135
C	ASN135

site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269\|PubMed:14760718, ECO:0000269\|PubMed:15084671, ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:19838169, ECO:0000269\|Ref.10

Chain	Residue	Details
I	ASN155
C	ASN155

site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:16263699, ECO:0000269\|PubMed:16335952, ECO:0000269\|Ref.10

Chain	Residue	Details
I	ASN192
C	ASN192

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	ASP102
B	HIS57

site_id	CSA10
Number of Residues	7
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	GLN192
B	ASP102
B	ALA195
B	GLY193
B	CYS191
B	HIS57
B	ASP194

site_id	CSA11
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	ALA195
H	GLY193
H	HIS57

site_id	CSA12
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	ASP102
B	ALA195
B	GLY193
B	HIS57

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ALA195
H	GLY196

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	HIS57

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	ALA195
B	GLY196

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ALA195
H	GLY193

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	ALA195
B	GLY193

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	ALA195
H	HIS57

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	ASP102
B	ALA195
B	HIS57

site_id	CSA9
Number of Residues	7
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	GLN192
H	ASP102
H	ALA195
H	GLY193
H	CYS191
H	HIS57
H	ASP194

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PDB entries from 2024-07-17

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