2GCZ

Solution Structure of alpha-Conotoxin OmIA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0030550	molecular_function	acetylcholine receptor inhibitor activity
A	0035792	cellular_component	host cell postsynaptic membrane
A	0035821	biological_process	modulation of process of another organism
A	0090729	molecular_function	toxin activity
A	0099106	molecular_function	ion channel regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NH2 A 18

Chain	Residue
A	PRO13
A	GLY17

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Functional Information from PROSITE/UniProt

site_id	PS60014
Number of Residues	15
Details	ALPHA_CONOTOXIN Alpha-conotoxin family signature. CCShPACNvnnpHIC

Chain	Residue	Details
A	CYS2-CYS16

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Peptide: {"description":"Alpha-conotoxin OmIA","featureId":"PRO_0000247849","evidences":[{"source":"PubMed","id":"16803900","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Region: {"description":"Ser-Xaa-Pro motif, crucial for potent interaction with nAChR","evidences":[{"source":"UniProtKB","id":"P56636","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Site: {"description":"Key residue for the high potency for alpha-7 nAChRs","evidences":[{"source":"PubMed","id":"34955864","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Glycine amide","evidences":[{"source":"PubMed","id":"16678128","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16803900","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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