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2GCO

Crystal structure of the human RhoC-GppNHp complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000281biological_processmitotic cytokinesis
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0007015biological_processactin filament organization
A0007165biological_processsignal transduction
A0007264biological_processsmall GTPase-mediated signal transduction
A0016020cellular_componentmembrane
A0019901molecular_functionprotein kinase binding
A0030335biological_processpositive regulation of cell migration
A0031334biological_processpositive regulation of protein-containing complex assembly
A0032154cellular_componentcleavage furrow
A0032420cellular_componentstereocilium
A0032956biological_processregulation of actin cytoskeleton organization
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043297biological_processapical junction assembly
A0044319biological_processwound healing, spreading of cells
A0051496biological_processpositive regulation of stress fiber assembly
A0060193biological_processpositive regulation of lipase activity
A0070062cellular_componentextracellular exosome
A1902766biological_processskeletal muscle satellite cell migration
B0000166molecular_functionnucleotide binding
B0000281biological_processmitotic cytokinesis
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0007015biological_processactin filament organization
B0007165biological_processsignal transduction
B0007264biological_processsmall GTPase-mediated signal transduction
B0016020cellular_componentmembrane
B0019901molecular_functionprotein kinase binding
B0030335biological_processpositive regulation of cell migration
B0031334biological_processpositive regulation of protein-containing complex assembly
B0032154cellular_componentcleavage furrow
B0032420cellular_componentstereocilium
B0032956biological_processregulation of actin cytoskeleton organization
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043297biological_processapical junction assembly
B0044319biological_processwound healing, spreading of cells
B0051496biological_processpositive regulation of stress fiber assembly
B0060193biological_processpositive regulation of lipase activity
B0070062cellular_componentextracellular exosome
B1902766biological_processskeletal muscle satellite cell migration
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1002
ChainResidue
ATHR19
ATHR37
AGNP1001
AHOH1049
AHOH1080

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 1004
ChainResidue
BHOH1059
BTHR19
BTHR37
BGNP1003
BHOH1027

site_idAC3
Number of Residues29
DetailsBINDING SITE FOR RESIDUE GNP A 1001
ChainResidue
AGLY14
AALA15
ACYS16
AGLY17
ALYS18
ATHR19
ACYS20
APHE30
AVAL35
ATHR37
AGLY62
ALYS118
AASP120
ALEU121
ASER160
AALA161
ALYS162
AMG1002
AHOH1009
AHOH1019
AHOH1035
AHOH1049
AHOH1077
AHOH1080
AHOH1101
AHOH1218
AHOH1219
AHOH1226
AHOH1230

site_idAC4
Number of Residues28
DetailsBINDING SITE FOR RESIDUE GNP B 1003
ChainResidue
BGLY14
BALA15
BCYS16
BGLY17
BLYS18
BTHR19
BCYS20
BPHE30
BTHR37
BGLY62
BLYS118
BASP120
BLEU121
BSER160
BALA161
BLYS162
BMG1004
BHOH1010
BHOH1012
BHOH1027
BHOH1053
BHOH1059
BHOH1060
BHOH1065
BHOH1124
BHOH1127
BHOH1132
BHOH1176

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
BGLY12
BASP59
BASN117

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: ADP-ribosylasparagine; by botulinum toxin => ECO:0000250
ChainResidueDetails
BASN41

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
BTYR34

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB => ECO:0000269|PubMed:24905543
ChainResidueDetails
BTHR37

218853

건을2024-04-24부터공개중

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