2GCI

The 1,1-proton transfer reaction mechanism by alpha-methylacyl-CoA racemase is catalyzed by an asparte/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0006629	biological_process	lipid metabolic process
A	0006637	biological_process	acyl-CoA metabolic process
A	0008111	molecular_function	alpha-methylacyl-CoA racemase activity
A	0016853	molecular_function	isomerase activity
A	0042803	molecular_function	protein homodimerization activity
B	0003824	molecular_function	catalytic activity
B	0006629	biological_process	lipid metabolic process
B	0006637	biological_process	acyl-CoA metabolic process
B	0008111	molecular_function	alpha-methylacyl-CoA racemase activity
B	0016853	molecular_function	isomerase activity
B	0042803	molecular_function	protein homodimerization activity
C	0003824	molecular_function	catalytic activity
C	0006629	biological_process	lipid metabolic process
C	0006637	biological_process	acyl-CoA metabolic process
C	0008111	molecular_function	alpha-methylacyl-CoA racemase activity
C	0016853	molecular_function	isomerase activity
C	0042803	molecular_function	protein homodimerization activity
D	0003824	molecular_function	catalytic activity
D	0006629	biological_process	lipid metabolic process
D	0006637	biological_process	acyl-CoA metabolic process
D	0008111	molecular_function	alpha-methylacyl-CoA racemase activity
D	0016853	molecular_function	isomerase activity
D	0042803	molecular_function	protein homodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE MRR A 1751

Chain	Residue
A	ARG38
A	LEU92
A	GLY113
A	GLY125
A	HIS126
A	ASP127
A	TYR130
A	ASP156
A	HOH1845
A	HOH1871
A	HOH1915
A	ALA59
A	HOH1957
B	TYR224
A	LEU61
A	LYS62
A	GLY83
A	TYR84
A	ARG85
A	VAL88
A	ARG91

---

site_id	AC2
Number of Residues	38
Details	BINDING SITE FOR RESIDUE MRR B 1752

Chain	Residue
A	MET207
A	MET216
A	TYR224
A	ILE240
A	GLU241
A	GOL1306
A	HOH1946
B	ILE16
B	ARG38
B	ALA59
B	ASP60
B	LEU61
B	LYS62
B	GLY83
B	TYR84
B	ARG85
B	VAL88
B	ARG91
B	LEU92
B	GLY113
B	GLY125
B	HIS126
B	ASP127
B	TYR130
B	ASP156
B	MET188
B	ASN263
B	ASP264
B	ARG265
B	ALA266
B	GOL1305
B	HOH1778
B	HOH1853
B	HOH1856
B	HOH1866
B	HOH1954
B	HOH1973
B	HOH1981

---

site_id	AC3
Number of Residues	25
Details	BINDING SITE FOR RESIDUE MRR C 1753

Chain	Residue
C	ARG38
C	ALA59
C	ASP60
C	LEU61
C	LYS62
C	GLY83
C	TYR84
C	ARG85
C	VAL88
C	ARG91
C	LEU92
C	GLY113
C	GLY125
C	HIS126
C	ASP127
C	TYR130
C	ASP156
C	HOH1814
C	HOH1819
C	HOH1907
C	HOH1946
C	HOH1953
C	HOH2015
C	HOH2075
D	TYR224

---

site_id	AC4
Number of Residues	31
Details	BINDING SITE FOR RESIDUE MRR D 1754

Chain	Residue
D	GLY113
D	GLY125
D	HIS126
D	ASP127
D	TYR130
D	ASP156
D	PRO261
D	ASP264
D	HOH1808
D	HOH1820
D	HOH1929
D	HOH1966
D	HOH2011
D	HOH2042
D	HOH2094
D	HOH2123
C	TYR224
C	GLU241
C	PRO242
C	GOL1302
D	ARG38
D	ALA59
D	ASP60
D	LEU61
D	LYS62
D	GLY83
D	TYR84
D	ARG85
D	VAL88
D	ARG91
D	LEU92

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 1301

Chain	Residue
C	ASP48
C	HOH1810
C	HOH2061
C	HOH2102
D	ALA201
D	MET202

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL C 1302

Chain	Residue
C	MET216
C	TYR223
C	ILE240
C	GLN262
C	ASN263
C	HOH1930
D	PRO261
D	ASN263
D	MRR1754
D	HOH1816

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 1303

Chain	Residue
C	HOH1820
C	HOH1853
D	MET216
D	TYR223
D	ILE240
D	PRO242
D	GLN262
D	ASN263

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 1304

Chain	Residue
A	ASN263
A	HOH1810
A	HOH1864
B	MET216
B	TYR223
B	ILE240
B	PRO242
B	GLN262
B	ASN263

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 1305

Chain	Residue
A	MET198
A	ALA201
A	MET202
A	MET207
A	HOH1912
B	ASP48
B	MET50
B	ALA266
B	MRR1752

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1306

Chain	Residue
A	MET216
A	TYR223
A	ILE240
A	GLN262
A	ASN263
B	PRO261
B	ASN263
B	MRR1752

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17320106","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22360758","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"17320106","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22360758","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17320106","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22360758","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1xvt

Chain	Residue	Details
A	ASP156

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1xvt

Chain	Residue	Details
B	ASP156

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1xvt

Chain	Residue	Details
C	ASP156

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1xvt

Chain	Residue	Details
D	ASP156

---