2GCE

The 1,1-proton transfer reaction mechanism by alpha-methylacyl-CoA racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0006629	biological_process	lipid metabolic process
A	0006637	biological_process	acyl-CoA metabolic process
A	0008111	molecular_function	alpha-methylacyl-CoA racemase activity
A	0016853	molecular_function	isomerase activity
A	0042803	molecular_function	protein homodimerization activity
B	0003824	molecular_function	catalytic activity
B	0006629	biological_process	lipid metabolic process
B	0006637	biological_process	acyl-CoA metabolic process
B	0008111	molecular_function	alpha-methylacyl-CoA racemase activity
B	0016853	molecular_function	isomerase activity
B	0042803	molecular_function	protein homodimerization activity
C	0003824	molecular_function	catalytic activity
C	0006629	biological_process	lipid metabolic process
C	0006637	biological_process	acyl-CoA metabolic process
C	0008111	molecular_function	alpha-methylacyl-CoA racemase activity
C	0016853	molecular_function	isomerase activity
C	0042803	molecular_function	protein homodimerization activity
D	0003824	molecular_function	catalytic activity
D	0006629	biological_process	lipid metabolic process
D	0006637	biological_process	acyl-CoA metabolic process
D	0008111	molecular_function	alpha-methylacyl-CoA racemase activity
D	0016853	molecular_function	isomerase activity
D	0042803	molecular_function	protein homodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE SFC A 1751

Chain	Residue
A	ILE16
A	VAL88
A	ARG91
A	LEU92
A	GLY113
A	GLY125
A	HIS126
A	ASP127
A	TYR130
A	ASP156
A	HOH2808
A	GLY17
A	HOH2833
A	HOH2978
A	HOH3008
B	MET198
A	ARG38
A	ALA59
A	LEU61
A	LYS62
A	GLY83
A	TYR84
A	ARG85

---

site_id	AC2
Number of Residues	27
Details	BINDING SITE FOR RESIDUE RFC A 2751

Chain	Residue
A	ILE16
A	ARG38
A	ALA59
A	LEU61
A	LYS62
A	GLY83
A	TYR84
A	ARG85
A	VAL88
A	ARG91
A	LEU92
A	GLY113
A	GLY125
A	HIS126
A	ASP127
A	TYR130
A	ASP156
A	ASP264
A	HOH2808
A	HOH2833
A	HOH2868
A	HOH2971
A	HOH2978
A	HOH3008
B	MET198
B	TYR224
B	ILE240

---

site_id	AC3
Number of Residues	27
Details	BINDING SITE FOR RESIDUE SFC B 1752

Chain	Residue
A	MET198
A	HOH2989
B	ILE16
B	GLY17
B	ARG38
B	ALA59
B	ASP60
B	LEU61
B	LYS62
B	GLY83
B	TYR84
B	ARG85
B	VAL88
B	ARG91
B	LEU92
B	GLY113
B	ALA124
B	GLY125
B	HIS126
B	ASP127
B	TYR130
B	ASN152
B	ASP156
B	HOH2823
B	HOH2855
B	HOH2858
B	HOH3009

---

site_id	AC4
Number of Residues	29
Details	BINDING SITE FOR RESIDUE RFC B 2752

Chain	Residue
B	HOH2823
B	HOH2855
B	HOH2858
B	HOH2879
B	HOH2929
B	HOH2968
B	HOH3009
A	TYR224
A	ILE240
A	HOH2989
B	ARG38
B	ALA59
B	ASP60
B	LEU61
B	LYS62
B	GLY83
B	TYR84
B	ARG85
B	VAL88
B	ARG91
B	LEU92
B	GLY113
B	ALA124
B	GLY125
B	HIS126
B	ASP127
B	TYR130
B	ASP156
B	MET188

---

site_id	AC5
Number of Residues	26
Details	BINDING SITE FOR RESIDUE SFC C 1753

Chain	Residue
C	ILE16
C	GLY17
C	ARG38
C	MET50
C	ALA59
C	ASP60
C	LEU61
C	LYS62
C	GLY83
C	TYR84
C	ARG85
C	VAL88
C	ARG91
C	LEU92
C	GLY113
C	GLY125
C	HIS126
C	ASP127
C	TYR130
C	ASN152
C	ASP156
C	HOH2829
C	HOH2877
C	HOH2904
C	HOH2999
D	MET198

---

site_id	AC6
Number of Residues	26
Details	BINDING SITE FOR RESIDUE RFC C 2753

Chain	Residue
C	ILE16
C	ARG38
C	ALA59
C	ASP60
C	LEU61
C	LYS62
C	GLY83
C	TYR84
C	ARG85
C	VAL88
C	ARG91
C	LEU92
C	GLY113
C	GLY125
C	HIS126
C	ASP127
C	TYR130
C	ASP156
C	ASP264
C	HOH2829
C	HOH2840
C	HOH2877
C	HOH2904
C	HOH2999
D	TYR224
D	ILE240

---

site_id	AC7
Number of Residues	27
Details	BINDING SITE FOR RESIDUE SFC D 1754

Chain	Residue
C	MET198
C	TYR224
C	ILE240
C	PHE244
D	ARG38
D	ALA59
D	LEU61
D	LYS62
D	GLY83
D	TYR84
D	ARG85
D	VAL88
D	ARG91
D	LEU92
D	GLY113
D	ALA124
D	GLY125
D	HIS126
D	ASP127
D	TYR130
D	ASN152
D	ASP156
D	MET188
D	HOH2816
D	HOH2837
D	HOH2866
D	HOH2962

---

site_id	AC8
Number of Residues	25
Details	BINDING SITE FOR RESIDUE RFC D 2754

Chain	Residue
C	ILE240
C	PHE244
D	ILE16
D	ARG38
D	ALA59
D	LEU61
D	LYS62
D	GLY83
D	TYR84
D	ARG85
D	VAL88
D	ARG91
D	LEU92
D	GLY113
D	ALA124
D	GLY125
D	HIS126
D	ASP127
D	TYR130
D	ASP156
D	HOH2816
D	HOH2837
D	HOH2866
D	HOH2916
D	HOH2962

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17320106","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22360758","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"17320106","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22360758","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17320106","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22360758","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1xvt

Chain	Residue	Details
A	ASP156

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1xvt

Chain	Residue	Details
B	ASP156

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1xvt

Chain	Residue	Details
C	ASP156

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1xvt

Chain	Residue	Details
D	ASP156

---