2GAO

Crystal Structure of Human SAR1a in Complex With GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003400	biological_process	regulation of COPII vesicle coating
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005765	cellular_component	lysosomal membrane
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0006886	biological_process	intracellular protein transport
A	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
A	0015031	biological_process	protein transport
A	0016050	biological_process	vesicle organization
A	0016192	biological_process	vesicle-mediated transport
A	0016787	molecular_function	hydrolase activity
A	0030127	cellular_component	COPII vesicle coat
A	0032580	cellular_component	Golgi cisterna membrane
A	0042953	biological_process	lipoprotein transport
A	0048208	biological_process	COPII vesicle coating
A	0061024	biological_process	membrane organization
A	0070971	cellular_component	endoplasmic reticulum exit site
A	0090110	biological_process	COPII-coated vesicle cargo loading
A	0140785	molecular_function	amino acid sensor activity
A	1903432	biological_process	regulation of TORC1 signaling
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1990253	biological_process	cellular response to leucine starvation
B	0000166	molecular_function	nucleotide binding
B	0003400	biological_process	regulation of COPII vesicle coating
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005765	cellular_component	lysosomal membrane
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0006886	biological_process	intracellular protein transport
B	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
B	0015031	biological_process	protein transport
B	0016050	biological_process	vesicle organization
B	0016192	biological_process	vesicle-mediated transport
B	0016787	molecular_function	hydrolase activity
B	0030127	cellular_component	COPII vesicle coat
B	0032580	cellular_component	Golgi cisterna membrane
B	0042953	biological_process	lipoprotein transport
B	0048208	biological_process	COPII vesicle coating
B	0061024	biological_process	membrane organization
B	0070971	cellular_component	endoplasmic reticulum exit site
B	0090110	biological_process	COPII-coated vesicle cargo loading
B	0140785	molecular_function	amino acid sensor activity
B	1903432	biological_process	regulation of TORC1 signaling
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1990253	biological_process	cellular response to leucine starvation

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GDP A 501

Chain	Residue
A	ASN35
A	ARG138
A	SER179
A	VAL180
A	LEU181
A	HOH631
A	HOH632
A	ALA36
A	GLY37
A	LYS38
A	THR39
A	THR40
A	ASN134
A	LYS135
A	ASP137

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GDP B 501

Chain	Residue
B	ASP34
B	ASN35
B	ALA36
B	GLY37
B	LYS38
B	THR39
B	THR40
B	HIS58
B	ASN134
B	LYS135
B	ASP137
B	ARG138
B	SER179
B	VAL180
B	LEU181
B	HOH628

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX B 601

Chain	Residue
B	GLY185
B	GLU188

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Region: {"description":"Mediates recruitment to ER membranes","evidences":[{"source":"UniProtKB","id":"Q9QVY3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36369712","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DZT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9Y6B6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36369712","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DZN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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