2GAH
Heterotetrameric sarcosine: structure of a diflavin metaloenzyme at 1.85 a resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0008115 | molecular_function | sarcosine oxidase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046653 | biological_process | tetrahydrofolate metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008115 | molecular_function | sarcosine oxidase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046653 | biological_process | tetrahydrofolate metabolic process |
| C | 0008115 | molecular_function | sarcosine oxidase activity |
| C | 1901053 | biological_process | sarcosine catabolic process |
| D | 0008115 | molecular_function | sarcosine oxidase activity |
| D | 0046653 | biological_process | tetrahydrofolate metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 101 |
| Chain | Residue |
| D | CYS6 |
| D | CYS9 |
| D | HIS59 |
| D | CYS63 |
| site_id | AC2 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NAD A 999 |
| Chain | Residue |
| A | ASP158 |
| A | GLU159 |
| A | ARG160 |
| A | GLY165 |
| A | THR166 |
| A | THR203 |
| A | THR204 |
| A | VAL205 |
| A | ALA248 |
| A | THR249 |
| A | GLY250 |
| A | SER295 |
| A | PHE381 |
| A | GLY417 |
| A | ALA418 |
| A | LEU423 |
| A | ASP424 |
| A | THR425 |
| A | TYR554 |
| A | HOH1010 |
| A | HOH1117 |
| A | HOH1151 |
| A | HOH1153 |
| A | HOH1155 |
| A | HOH1163 |
| A | HOH1440 |
| A | HOH2108 |
| A | HOH2368 |
| A | VAL134 |
| A | GLY135 |
| A | GLY137 |
| A | PRO138 |
| A | ALA139 |
| site_id | AC3 |
| Number of Residues | 41 |
| Details | BINDING SITE FOR RESIDUE FAD B 501 |
| Chain | Residue |
| B | GLY28 |
| B | GLY30 |
| B | GLY31 |
| B | HIS32 |
| B | LEU52 |
| B | GLU53 |
| B | LYS54 |
| B | GLY60 |
| B | ASN61 |
| B | MSE62 |
| B | ARG64 |
| B | ASN65 |
| B | THR66 |
| B | THR67 |
| B | ILE68 |
| B | CYS195 |
| B | GLU196 |
| B | VAL197 |
| B | ALA225 |
| B | GLY226 |
| B | ALA227 |
| B | HIS229 |
| B | LEU233 |
| B | LEU248 |
| B | ALA250 |
| B | GLY327 |
| B | GLY354 |
| B | THR355 |
| B | GLY356 |
| B | GLY357 |
| B | PHE358 |
| B | LYS359 |
| B | FOA503 |
| B | HOH1007 |
| B | HOH1054 |
| B | HOH1090 |
| B | HOH1209 |
| B | HOH1295 |
| B | HOH1317 |
| B | HOH1465 |
| B | HOH1852 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE FMN B 502 |
| Chain | Residue |
| B | HOH1986 |
| A | LYS510 |
| A | ARG511 |
| A | THR517 |
| A | GLN521 |
| A | THR549 |
| A | ARG551 |
| A | HOH1150 |
| A | HOH1393 |
| B | ALA63 |
| B | ARG64 |
| B | ASN65 |
| B | THR67 |
| B | HIS173 |
| B | VAL252 |
| B | LYS278 |
| B | GLU280 |
| B | ARG323 |
| B | TRP325 |
| B | HOH1044 |
| B | HOH1565 |
| B | HOH1606 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE FOA B 503 |
| Chain | Residue |
| B | THR66 |
| B | ILE68 |
| B | ARG70 |
| B | MSE265 |
| B | TYR272 |
| B | THR355 |
| B | GLY356 |
| B | LYS359 |
| B | VAL403 |
| B | FAD501 |
| B | HOH1172 |
