Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2GA6

The crystal structure of SARS nsp10 without zinc ion as additive

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0008270	molecular_function	zinc ion binding
A	0019079	biological_process	viral genome replication
B	0003723	molecular_function	RNA binding
B	0008270	molecular_function	zinc ion binding
B	0019079	biological_process	viral genome replication
C	0003723	molecular_function	RNA binding
C	0008270	molecular_function	zinc ion binding
C	0019079	biological_process	viral genome replication
D	0003723	molecular_function	RNA binding
D	0008270	molecular_function	zinc ion binding
D	0019079	biological_process	viral genome replication
E	0003723	molecular_function	RNA binding
E	0008270	molecular_function	zinc ion binding
E	0019079	biological_process	viral genome replication
F	0003723	molecular_function	RNA binding
F	0008270	molecular_function	zinc ion binding
F	0019079	biological_process	viral genome replication
G	0003723	molecular_function	RNA binding
G	0008270	molecular_function	zinc ion binding
G	0019079	biological_process	viral genome replication
H	0003723	molecular_function	RNA binding
H	0008270	molecular_function	zinc ion binding
H	0019079	biological_process	viral genome replication
I	0003723	molecular_function	RNA binding
I	0008270	molecular_function	zinc ion binding
I	0019079	biological_process	viral genome replication
J	0003723	molecular_function	RNA binding
J	0008270	molecular_function	zinc ion binding
J	0019079	biological_process	viral genome replication
K	0003723	molecular_function	RNA binding
K	0008270	molecular_function	zinc ion binding
K	0019079	biological_process	viral genome replication
L	0003723	molecular_function	RNA binding
L	0008270	molecular_function	zinc ion binding
L	0019079	biological_process	viral genome replication
M	0003723	molecular_function	RNA binding
M	0008270	molecular_function	zinc ion binding
M	0019079	biological_process	viral genome replication
N	0003723	molecular_function	RNA binding
N	0008270	molecular_function	zinc ion binding
N	0019079	biological_process	viral genome replication
O	0003723	molecular_function	RNA binding
O	0008270	molecular_function	zinc ion binding
O	0019079	biological_process	viral genome replication
P	0003723	molecular_function	RNA binding
P	0008270	molecular_function	zinc ion binding
P	0019079	biological_process	viral genome replication
Q	0003723	molecular_function	RNA binding
Q	0008270	molecular_function	zinc ion binding
Q	0019079	biological_process	viral genome replication
R	0003723	molecular_function	RNA binding
R	0008270	molecular_function	zinc ion binding
R	0019079	biological_process	viral genome replication
S	0003723	molecular_function	RNA binding
S	0008270	molecular_function	zinc ion binding
S	0019079	biological_process	viral genome replication
T	0003723	molecular_function	RNA binding
T	0008270	molecular_function	zinc ion binding
T	0019079	biological_process	viral genome replication
U	0003723	molecular_function	RNA binding
U	0008270	molecular_function	zinc ion binding
U	0019079	biological_process	viral genome replication
V	0003723	molecular_function	RNA binding
V	0008270	molecular_function	zinc ion binding
V	0019079	biological_process	viral genome replication
W	0003723	molecular_function	RNA binding
W	0008270	molecular_function	zinc ion binding
W	0019079	biological_process	viral genome replication
X	0003723	molecular_function	RNA binding
X	0008270	molecular_function	zinc ion binding
X	0019079	biological_process	viral genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 998

Chain	Residue
A	CYS74
A	CYS77
A	HIS83
A	CYS90

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 999

Chain	Residue
A	CYS117
A	CYS120
A	CYS128
A	SER129
A	HOH1045

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 998

Chain	Residue
B	CYS74
B	CYS77
B	HIS83
B	CYS90

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 999

Chain	Residue
B	CYS117
B	CYS120
B	CYS128
B	SER129
B	HOH1036

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 998

Chain	Residue
C	CYS74
C	CYS77
C	HIS83
C	CYS90

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 999

Chain	Residue
C	CYS117
C	CYS120
C	CYS128
C	SER129
C	HOH1042

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 998

Chain	Residue
D	CYS74
D	CYS77
D	HIS83
D	CYS90

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 999

Chain	Residue
D	CYS117
D	CYS120
D	CYS128
D	HOH1028

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 998

Chain	Residue
E	CYS74
E	CYS77
E	HIS83
E	CYS90

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 999

Chain	Residue
E	CYS117
E	CYS120
E	CYS128
E	HOH1041

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 998

Chain	Residue
F	CYS74
F	CYS77
F	HIS83
F	CYS90

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN F 999

Chain	Residue
F	CYS117
F	CYS120
F	CYS128
F	SER129
F	HOH1043

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 998

Chain	Residue
G	CYS74
G	CYS77
G	HIS83
G	CYS90

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN G 999

Chain	Residue
G	CYS117
G	CYS120
G	CYS128
G	SER129
G	HOH1047

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 998

Chain	Residue
H	CYS74
H	CYS77
H	HIS83
H	CYS90

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN H 999

Chain	Residue
H	CYS117
H	CYS120
H	CYS128
H	SER129
H	HOH1040

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 998

Chain	Residue
I	CYS74
I	CYS77
I	HIS83
I	CYS90

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN I 999

Chain	Residue
I	CYS117
I	CYS120
I	CYS128
I	SER129
I	HOH1036

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 998

Chain	Residue
J	CYS74
J	CYS77
J	HIS83
J	CYS90

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN J 999

Chain	Residue
J	CYS117
J	CYS120
J	CYS128
J	SER129
J	HOH1029

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 998

Chain	Residue
K	CYS74
K	CYS77
K	HIS83
K	CYS90

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN K 999

Chain	Residue
K	CYS117
K	CYS120
K	CYS128
K	SER129
K	HOH1039

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 998

Chain	Residue
L	HIS83
L	CYS90
L	CYS74
L	CYS77

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN L 999

Chain	Residue
L	CYS117
L	CYS120
L	CYS128
L	SER129
L	HOH1047

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN M 998

Chain	Residue
M	CYS74
M	TYR76
M	CYS77
M	HIS83
M	CYS90

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN M 999

Chain	Residue
M	CYS117
M	CYS120
M	CYS128
M	SER129
M	HOH1022
M	HOH1055

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN N 998

Chain	Residue
N	CYS74
N	CYS77
N	HIS83
N	CYS90

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN N 999

Chain	Residue
N	CYS117
N	CYS120
N	CYS128
N	SER129
N	HOH1030

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN O 998

Chain	Residue
O	CYS74
O	CYS77
O	HIS83
O	CYS90

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN O 999

Chain	Residue
O	CYS117
O	CYS120
O	CYS128
O	SER129
O	HOH1052

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN P 998

Chain	Residue
P	CYS74
P	TYR76
P	CYS77
P	HIS83
P	CYS90

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P 999

Chain	Residue
P	CYS117
P	CYS120
P	CYS128
P	HOH1050

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN Q 998

Chain	Residue
Q	CYS74
Q	CYS77
Q	HIS83
Q	CYS90

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN Q 999

Chain	Residue
Q	CYS117
Q	CYS120
Q	CYS128
Q	SER129
Q	HOH1033

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN R 998

Chain	Residue
R	CYS74
R	CYS77
R	HIS83
R	CYS90

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN R 999

Chain	Residue
R	CYS117
R	CYS120
R	CYS128
R	SER129
R	HOH1038

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN S 998

Chain	Residue
S	CYS74
S	CYS77
S	HIS83
S	CYS90
S	HOH1005

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN S 999

Chain	Residue
S	CYS117
S	CYS120
S	CYS128
S	SER129
S	HOH1033

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN T 998

Chain	Residue
T	CYS74
T	CYS77
T	HIS83
T	CYS90

site_id	EC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN T 999

Chain	Residue
T	CYS117
T	CYS120
T	CYS128
T	SER129
T	HOH1032

site_id	EC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN U 998

Chain	Residue
U	CYS74
U	CYS77
U	HIS83
U	CYS90

site_id	EC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN U 999

Chain	Residue
U	CYS117
U	CYS120
U	CYS128
U	SER129
U	HOH1025

site_id	EC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN V 998

Chain	Residue
V	CYS74
V	CYS77
V	HIS83
V	CYS90

site_id	EC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN V 999

Chain	Residue
V	CYS117
V	CYS120
V	CYS128
V	SER129
V	HOH1046

site_id	EC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN W 998

Chain	Residue
W	CYS74
W	CYS77
W	HIS83
W	CYS90

site_id	FC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN W 999

Chain	Residue
W	CYS117
W	CYS120
W	CYS128
W	SER129
W	HOH1036

site_id	FC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN X 998

Chain	Residue
X	CYS74
X	TYR76
X	CYS77
X	HIS83
X	CYS90

site_id	FC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN X 999

Chain	Residue
X	CYS117
X	CYS120
X	CYS128
X	SER129
X	HOH1034

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	696
Details	ZN_FING:

Chain	Residue	Details
A	CYS74-CYS90
E	CYS117-CYS130
F	CYS74-CYS90
F	CYS117-CYS130
G	CYS74-CYS90
G	CYS117-CYS130
H	CYS74-CYS90
H	CYS117-CYS130
I	CYS74-CYS90
I	CYS117-CYS130
J	CYS74-CYS90
A	CYS117-CYS130
J	CYS117-CYS130
K	CYS74-CYS90
K	CYS117-CYS130
L	CYS74-CYS90
L	CYS117-CYS130
M	CYS74-CYS90
M	CYS117-CYS130
N	CYS74-CYS90
N	CYS117-CYS130
O	CYS74-CYS90
B	CYS74-CYS90
O	CYS117-CYS130
P	CYS74-CYS90
P	CYS117-CYS130
Q	CYS74-CYS90
Q	CYS117-CYS130
R	CYS74-CYS90
R	CYS117-CYS130
S	CYS74-CYS90
S	CYS117-CYS130
T	CYS74-CYS90
B	CYS117-CYS130
T	CYS117-CYS130
U	CYS74-CYS90
U	CYS117-CYS130
V	CYS74-CYS90
V	CYS117-CYS130
W	CYS74-CYS90
W	CYS117-CYS130
X	CYS74-CYS90
X	CYS117-CYS130
C	CYS74-CYS90
C	CYS117-CYS130
D	CYS74-CYS90
D	CYS117-CYS130
E	CYS74-CYS90

site_id	SWS_FT_FI2
Number of Residues	192
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU01297

Chain	Residue	Details
A	CYS74
B	CYS77
M	CYS90
M	CYS117
M	CYS120
M	CYS128
M	CYS130
N	CYS74
N	CYS77
N	HIS83
N	CYS90
N	CYS117
B	HIS83
N	CYS120
N	CYS128
N	CYS130
O	CYS74
O	CYS77
O	HIS83
O	CYS90
O	CYS117
O	CYS120
O	CYS128
B	CYS90
O	CYS130
P	CYS74
P	CYS77
P	HIS83
P	CYS90
P	CYS117
P	CYS120
P	CYS128
P	CYS130
Q	CYS74
B	CYS117
Q	CYS77
Q	HIS83
Q	CYS90
Q	CYS117
Q	CYS120
Q	CYS128
Q	CYS130
R	CYS74
R	CYS77
R	HIS83
B	CYS120
R	CYS90
R	CYS117
R	CYS120
R	CYS128
R	CYS130
S	CYS74
S	CYS77
S	HIS83
S	CYS90
S	CYS117
B	CYS128
S	CYS120
S	CYS128
S	CYS130
T	CYS74
T	CYS77
T	HIS83
T	CYS90
T	CYS117
T	CYS120
T	CYS128
B	CYS130
T	CYS130
U	CYS74
U	CYS77
U	HIS83
U	CYS90
U	CYS117
U	CYS120
U	CYS128
U	CYS130
V	CYS74
C	CYS74
V	CYS77
V	HIS83
V	CYS90
V	CYS117
V	CYS120
V	CYS128
V	CYS130
W	CYS74
W	CYS77
W	HIS83
C	CYS77
W	CYS90
W	CYS117
W	CYS120
W	CYS128
W	CYS130
X	CYS74
X	CYS77
X	HIS83
X	CYS90
X	CYS117
C	HIS83
X	CYS120
X	CYS128
X	CYS130
A	CYS77
C	CYS90
C	CYS117
C	CYS120
C	CYS128
C	CYS130
D	CYS74
D	CYS77
D	HIS83
D	CYS90
D	CYS117
A	HIS83
D	CYS120
D	CYS128
D	CYS130
E	CYS74
E	CYS77
E	HIS83
E	CYS90
E	CYS117
E	CYS120
E	CYS128
A	CYS90
E	CYS130
F	CYS74
F	CYS77
F	HIS83
F	CYS90
F	CYS117
F	CYS120
F	CYS128
F	CYS130
G	CYS74
A	CYS117
G	CYS77
G	HIS83
G	CYS90
G	CYS117
G	CYS120
G	CYS128
G	CYS130
H	CYS74
H	CYS77
H	HIS83
A	CYS120
H	CYS90
H	CYS117
H	CYS120
H	CYS128
H	CYS130
I	CYS74
I	CYS77
I	HIS83
I	CYS90
I	CYS117
A	CYS128
I	CYS120
I	CYS128
I	CYS130
J	CYS74
J	CYS77
J	HIS83
J	CYS90
J	CYS117
J	CYS120
J	CYS128
A	CYS130
J	CYS130
K	CYS74
K	CYS77
K	HIS83
K	CYS90
K	CYS117
K	CYS120
K	CYS128
K	CYS130
L	CYS74
B	CYS74
L	CYS77
L	HIS83
L	CYS90
L	CYS117
L	CYS120
L	CYS128
L	CYS130
M	CYS74
M	CYS77
M	HIS83

site_id	SWS_FT_FI3
Number of Residues	24
Details	SITE: Cleavage; by 3CL-PRO => ECO:0000269\|PubMed:14561748

Chain	Residue	Details
A	GLN139
J	GLN139
K	GLN139
L	GLN139
M	GLN139
N	GLN139
O	GLN139
P	GLN139
Q	GLN139
R	GLN139
S	GLN139
B	GLN139
T	GLN139
U	GLN139
V	GLN139
W	GLN139
X	GLN139
C	GLN139
D	GLN139
E	GLN139
F	GLN139
G	GLN139
H	GLN139
I	GLN139

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)