2GA4
Stx2 with adenine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017148 | biological_process | negative regulation of translation |
| A | 0030598 | molecular_function | rRNA N-glycosylase activity |
| A | 0090729 | molecular_function | toxin activity |
| A | 0098676 | biological_process | modulation of host virulence by virus |
| B | 0005576 | cellular_component | extracellular region |
| B | 0019836 | biological_process | hemolysis by symbiont of host erythrocytes |
| B | 0090729 | molecular_function | toxin activity |
| B | 0098676 | biological_process | modulation of host virulence by virus |
| C | 0005576 | cellular_component | extracellular region |
| C | 0019836 | biological_process | hemolysis by symbiont of host erythrocytes |
| C | 0090729 | molecular_function | toxin activity |
| C | 0098676 | biological_process | modulation of host virulence by virus |
| D | 0005576 | cellular_component | extracellular region |
| D | 0019836 | biological_process | hemolysis by symbiont of host erythrocytes |
| D | 0090729 | molecular_function | toxin activity |
| D | 0098676 | biological_process | modulation of host virulence by virus |
| E | 0005576 | cellular_component | extracellular region |
| E | 0019836 | biological_process | hemolysis by symbiont of host erythrocytes |
| E | 0090729 | molecular_function | toxin activity |
| E | 0098676 | biological_process | modulation of host virulence by virus |
| F | 0005576 | cellular_component | extracellular region |
| F | 0019836 | biological_process | hemolysis by symbiont of host erythrocytes |
| F | 0090729 | molecular_function | toxin activity |
| F | 0098676 | biological_process | modulation of host virulence by virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA F 711 |
| Chain | Residue |
| F | SER53 |
| F | THR55 |
| F | SER60 |
| F | GLY61 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 712 |
| Chain | Residue |
| B | SER53 |
| B | THR55 |
| B | SER60 |
| B | GLY61 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 713 |
| Chain | Residue |
| A | SER278 |
| A | ASN279 |
| A | FMT709 |
| A | HOH838 |
| C | HOH729 |
| A | ARG266 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 714 |
| Chain | Residue |
| A | THR22 |
| A | SER25 |
| A | HOH767 |
| A | HOH791 |
| A | HOH895 |
| A | HOH961 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 715 |
| Chain | Residue |
| A | SER15 |
| A | SER19 |
| A | HOH825 |
| A | HOH832 |
| A | HOH943 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ADE A 701 |
| Chain | Residue |
| A | LEU76 |
| A | TYR77 |
| A | VAL78 |
| A | SER112 |
| A | TYR114 |
| A | VAL162 |
| A | ALA166 |
| A | ARG170 |
| A | HOH830 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 1PS F 702 |
| Chain | Residue |
| F | ASN14 |
| F | ASP16 |
| F | THR18 |
| F | TRP29 |
| F | HOH722 |
| F | HOH762 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1PS B 703 |
| Chain | Residue |
| B | ASN14 |
| B | GLU15 |
| B | ASP16 |
| B | THR18 |
| B | TRP29 |
| B | HOH714 |
| B | HOH760 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1PS C 704 |
| Chain | Residue |
| C | ASN14 |
| C | ASP16 |
| C | THR18 |
| C | TRP29 |
| C | HOH742 |
| C | HOH750 |
| C | HOH766 |
| D | SER58 |
| site_id | BC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 1PS D 705 |
| Chain | Residue |
| C | SER58 |
| D | ASN14 |
| D | GLU15 |
| D | ASP16 |
| D | THR18 |
| D | TRP29 |
| D | FMT708 |
| D | HOH728 |
| D | HOH745 |
| D | HOH773 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO F 716 |
| Chain | Residue |
| A | SER229 |
| A | PHE291 |
| B | TYR13 |
| F | SER31 |
| F | ARG32 |
| F | TRP33 |
| F | ASN34 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT A 706 |
| Chain | Residue |
| A | GLN175 |
| A | ARG176 |
| A | ARG179 |
| A | HOH751 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT E 707 |
| Chain | Residue |
| A | ARG179 |
| A | THR294 |
| A | HOH723 |
| E | ARG32 |
| E | TRP33 |
| E | ASN34 |
| E | HOH721 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT D 708 |
| Chain | Residue |
| D | THR20 |
| D | GLY59 |
| D | 1PS705 |
| D | HOH746 |
| D | HOH748 |
| site_id | BC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FMT A 709 |
| Chain | Residue |
| A | ASN207 |
| A | GLN261 |
| A | THR263 |
| A | ASP265 |
| A | ARG266 |
| A | PRO267 |
| A | NA713 |
| A | HOH760 |
| C | HOH729 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT C 710 |
| Chain | Residue |
| C | HOH730 |
| C | HOH734 |
| D | HOH744 |
| C | ARG32 |
| C | TRP33 |
Functional Information from PROSITE/UniProt
| site_id | PS00275 |
| Number of Residues | 17 |
| Details | SHIGA_RICIN Shiga/ricin ribosomal inactivating toxins active site signature. VtVTaEALRFRqIQreF |
| Chain | Residue | Details |
| A | VAL162-PHE178 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU167 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by furin => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG250 |
