Functional Information from GO Data
Chain | GOid | namespace | contents |
E | 0004175 | molecular_function | endopeptidase activity |
E | 0004252 | molecular_function | serine-type endopeptidase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005576 | cellular_component | extracellular region |
E | 0005615 | cellular_component | extracellular space |
E | 0006508 | biological_process | proteolysis |
E | 0007586 | biological_process | digestion |
E | 0008236 | molecular_function | serine-type peptidase activity |
E | 0046872 | molecular_function | metal ion binding |
E | 0097180 | cellular_component | serine protease inhibitor complex |
E | 0097655 | molecular_function | serpin family protein binding |
I | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
I | 0005576 | cellular_component | extracellular region |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA E 401 |
Chain | Residue |
E | GLU70 |
E | ASN72 |
E | VAL75 |
E | GLU80 |
E | HOH742 |
E | HOH746 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 E 501 |
Chain | Residue |
E | HOH857 |
E | HOH883 |
E | HOH913 |
E | ASN95 |
E | THR98 |
E | ASN100 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 E 502 |
Chain | Residue |
E | ARG66 |
E | HOH760 |
E | HOH802 |
I | ASP20 |
I | ARG21 |
I | HOH753 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 E 503 |
Chain | Residue |
E | LYS87 |
E | ASN95 |
E | ASN97 |
E | LYS107 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 E 504 |
Chain | Residue |
E | SER150 |
E | TYR151 |
E | LYS169 |
E | GLY174 |
E | HOH722 |
E | HOH782 |
E | HOH858 |
site_id | AC6 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE P6G I 701 |
Chain | Residue |
E | SER96 |
E | ASN97 |
E | THR98 |
E | LEU99 |
E | PRO173 |
E | GLN175 |
E | TRP215 |
E | HOH761 |
I | GLU23 |
I | THR25 |
I | GLN31 |
I | ARG33 |
I | HOH725 |
I | HOH766 |
site_id | AC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PGE E 702 |
Chain | Residue |
E | GLY18 |
E | TYR184 |
E | GLU186 |
E | GLY187 |
E | LYS188 |
E | GLY188 |
E | HOH884 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO E 703 |
Chain | Residue |
E | TYR20 |
E | CYS22 |
E | THR26 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ACY E 601 |
Chain | Residue |
E | LYS145 |
E | SER146 |
E | SER147 |
E | HOH867 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ACY E 602 |
Chain | Residue |
E | GLY148 |
E | THR149 |
E | HOH759 |
E | HOH848 |
Functional Information from PROSITE/UniProt
site_id | PS00134 |
Number of Residues | 6 |
Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC |
Chain | Residue | Details |
E | VAL53-CYS58 | |
site_id | PS00135 |
Number of Residues | 12 |
Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV |
Chain | Residue | Details |
E | ASP189-VAL200 | |
site_id | PS00281 |
Number of Residues | 16 |
Details | BOWMAN_BIRK Bowman-Birk serine protease inhibitors family signature. CsdvrlnSCHSACKSC |
Chain | Residue | Details |
I | CYS34-CYS49 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | SITE: Reactive bond for trypsin => ECO:0000250 |
Chain | Residue | Details |
I | LYS26 | |
E | LEU105 | |
E | PRO198 | |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | SITE: Reactive bond for chymotrypsin => ECO:0000250 |
Chain | Residue | Details |
I | PHE53 | |
E | VAL75 | |
E | GLY78 | |
E | ILE83 | |
E | GLN192 | |
E | SER195 | |
E | PRO198 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
E | ASP102 | |
E | HIS57 | |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
E | SER195 | |
E | GLY196 | |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
E | SER195 | |
E | GLY193 | |
site_id | CSA4 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
E | ASP102 | |
E | SER195 | |
E | HIS57 | |
site_id | CSA5 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
E | ASP102 | |
E | SER195 | |
E | GLY193 | |
E | HIS57 | |
site_id | CSA6 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
E | ASP102 | |
E | SER195 | |
E | HIS57 | |
E | GLY196 | |