2G6Z
Crystal structure of human DUSP5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
| B | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
| C | 0006470 | biological_process | protein dephosphorylation |
| C | 0016311 | biological_process | dephosphorylation |
| C | 0017017 | molecular_function | MAP kinase tyrosine/serine/threonine phosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | SER263 |
| A | GLU264 |
| A | ALA265 |
| A | GLY266 |
| A | ILE267 |
| A | SER268 |
| A | ARG269 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 502 |
| Chain | Residue |
| A | ARG214 |
| A | GLU264 |
| A | ARG269 |
| A | HOH8 |
| A | ARG213 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 503 |
| Chain | Residue |
| B | HOH29 |
| B | SER263 |
| B | GLU264 |
| B | ALA265 |
| B | GLY266 |
| B | ILE267 |
| B | SER268 |
| B | ARG269 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 504 |
| Chain | Residue |
| B | HOH31 |
| B | ARG213 |
| B | ARG214 |
| B | GLU264 |
| B | ARG269 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 505 |
| Chain | Residue |
| C | SER263 |
| C | GLU264 |
| C | ALA265 |
| C | GLY266 |
| C | ILE267 |
| C | SER268 |
| C | ARG269 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 506 |
| Chain | Residue |
| C | SER212 |
| C | ARG213 |
| C | ARG214 |
| C | GLU264 |
| C | ARG269 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 423 |
| Details | Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17078075","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
