2G5C

Crystal Structure of Prephenate Dehydrogenase from Aquifex aeolicus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004665	molecular_function	prephenate dehydrogenase (NADP+) activity
A	0006571	biological_process	tyrosine biosynthetic process
A	0008652	biological_process	amino acid biosynthetic process
A	0008977	molecular_function	prephenate dehydrogenase (NAD+) activity
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0070403	molecular_function	NAD+ binding
B	0000166	molecular_function	nucleotide binding
B	0004665	molecular_function	prephenate dehydrogenase (NADP+) activity
B	0006571	biological_process	tyrosine biosynthetic process
B	0008652	biological_process	amino acid biosynthetic process
B	0008977	molecular_function	prephenate dehydrogenase (NAD+) activity
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0070403	molecular_function	NAD+ binding
C	0000166	molecular_function	nucleotide binding
C	0004665	molecular_function	prephenate dehydrogenase (NADP+) activity
C	0006571	biological_process	tyrosine biosynthetic process
C	0008652	biological_process	amino acid biosynthetic process
C	0008977	molecular_function	prephenate dehydrogenase (NAD+) activity
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0070403	molecular_function	NAD+ binding
D	0000166	molecular_function	nucleotide binding
D	0004665	molecular_function	prephenate dehydrogenase (NADP+) activity
D	0006571	biological_process	tyrosine biosynthetic process
D	0008652	biological_process	amino acid biosynthetic process
D	0008977	molecular_function	prephenate dehydrogenase (NAD+) activity
D	0009073	biological_process	aromatic amino acid family biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD A 3686

Chain	Residue
A	GLY37
A	SER98
A	SER99
A	PRO100
A	VAL101
A	THR103
A	ILE107
A	GLN124
A	SER126
A	ALA150
A	GLY151
A	VAL38
A	GLU153
A	LYS154
A	SER155
A	GLY156
A	HOH3692
A	GLY39
A	PHE40
A	MSE41
A	TYR61
A	ASP62
A	ILE63
A	SER67

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site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE NAD B 4686

Chain	Residue
B	GLY37
B	VAL38
B	GLY39
B	PHE40
B	MSE41
B	TYR61
B	ASP62
B	ILE63
B	SER67
B	SER98
B	SER99
B	PRO100
B	VAL101
B	ILE107
B	GLN124
B	SER126
B	THR152
B	LYS154
B	SER155
B	GLY156
B	HOH4687
B	HOH4727

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site_id	AC3
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD C 5686

Chain	Residue
C	GLY37
C	VAL38
C	GLY39
C	PHE40
C	MSE41
C	TYR61
C	ASP62
C	ILE63
C	ASN64
C	SER67
C	SER98
C	SER99
C	PRO100
C	VAL101
C	THR103
C	ILE107
C	GLN124
C	SER126
C	PRO148
C	ALA150
C	GLY151
C	THR152
C	GLY156
C	MSE258
C	HOH5689
C	HOH5692
C	HOH5800

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site_id	AC4
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD D 6686

Chain	Residue
D	HOH6797
D	GLY37
D	VAL38
D	GLY39
D	PHE40
D	MSE41
D	TYR61
D	ASP62
D	ILE63
D	ASN64
D	SER67
D	SER98
D	SER99
D	PRO100
D	VAL101
D	ILE107
D	GLN124
D	SER126
D	ALA150
D	GLY151
D	THR152
D	GLY156
D	MSE258
D	HOH6691
D	HOH6694
D	HOH6717
D	HOH6725

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