2G4K

Anomalous substructure of human ADP-ribosylhydrolase 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006281	biological_process	DNA repair
A	0006287	biological_process	base-excision repair, gap-filling
A	0006974	biological_process	DNA damage response
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0060546	biological_process	negative regulation of necroptotic process
A	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
A	0071451	biological_process	cellular response to superoxide
A	0090734	cellular_component	site of DNA damage
A	0140290	biological_process	peptidyl-serine ADP-deribosylation
A	0140292	molecular_function	ADP-ribosylserine hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 351

Chain	Residue
A	THR60
A	ASP61
A	ASP62
A	ASP300
A	HOH355
A	HOH357

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 352

Chain	Residue
A	THR301
A	HOH355
A	HOH356
A	GLU25
A	ASP298
A	ASP300

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 353

Chain	Residue
A	GLN211

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 354

Chain	Residue
A	SER5
A	ARG8

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7ARW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ARW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Glutamate flap","evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---