2G46

structure of vSET in complex with meK27 H3 Pept. and cofactor product SAH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006338	biological_process	chromatin remodeling
A	0008168	molecular_function	methyltransferase activity
A	0032259	biological_process	methylation
A	0042802	molecular_function	identical protein binding
A	0062122	molecular_function	histone H3K37 methyltransferase activity
B	0006338	biological_process	chromatin remodeling
B	0008168	molecular_function	methyltransferase activity
B	0032259	biological_process	methylation
B	0042802	molecular_function	identical protein binding
B	0062122	molecular_function	histone H3K37 methyltransferase activity
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0030527	molecular_function	structural constituent of chromatin
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0030527	molecular_function	structural constituent of chromatin

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SAH A 301

Chain	Residue
A	TYR16
A	TYR50
A	ALA66
A	ILE67
A	ASN69
A	HIS70
A	TYR105
A	LEU111
C	MLZ215

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SAH B 302

Chain	Residue
B	TYR16
B	TYR50
B	ALA66
B	ILE67
B	ASN69
B	HIS70
B	TYR105
B	LEU111
D	MLZ215

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Functional Information from PROSITE/UniProt

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
C	LYS202-LEU208

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