2G2B

NMR structure of the human allograft inflammatory factor 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001726	cellular_component	ruffle
A	0001774	biological_process	microglial cell activation
A	0001891	cellular_component	phagocytic cup
A	0003779	molecular_function	actin binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005884	cellular_component	actin filament
A	0005886	cellular_component	plasma membrane
A	0006911	biological_process	phagocytosis, engulfment
A	0006954	biological_process	inflammatory response
A	0008284	biological_process	positive regulation of cell population proliferation
A	0010468	biological_process	regulation of gene expression
A	0016020	cellular_component	membrane
A	0016601	biological_process	Rac protein signal transduction
A	0030027	cellular_component	lamellipodium
A	0030041	biological_process	actin filament polymerization
A	0030046	biological_process	parallel actin filament bundle assembly
A	0030335	biological_process	positive regulation of cell migration
A	0032587	cellular_component	ruffle membrane
A	0032722	biological_process	positive regulation of chemokine production
A	0032755	biological_process	positive regulation of interleukin-6 production
A	0034599	biological_process	cellular response to oxidative stress
A	0042102	biological_process	positive regulation of T cell proliferation
A	0042995	cellular_component	cell projection
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0048661	biological_process	positive regulation of smooth muscle cell proliferation
A	0048662	biological_process	negative regulation of smooth muscle cell proliferation
A	0050921	biological_process	positive regulation of chemotaxis
A	0051015	molecular_function	actin filament binding
A	0051017	biological_process	actin filament bundle assembly
A	0051764	biological_process	actin crosslink formation
A	0071346	biological_process	cellular response to type II interferon
A	0071672	biological_process	negative regulation of smooth muscle cell chemotaxis
A	0071673	biological_process	positive regulation of smooth muscle cell chemotaxis
A	0071677	biological_process	positive regulation of mononuclear cell migration
A	0090026	biological_process	positive regulation of monocyte chemotaxis
A	0090271	biological_process	positive regulation of fibroblast growth factor production
A	0097178	biological_process	ruffle assembly
A	0097386	cellular_component	glial cell projection
A	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
A	2000406	biological_process	positive regulation of T cell migration

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	35
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	34
Details	Domain: {"description":"EF-hand 2; degenerate","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	19
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"UniProtKB","id":"P81076","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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