2G0A

X-ray structure of mouse pyrimidine 5'-nucleotidase type 1 with lead(II) bound in active site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005737	cellular_component	cytoplasm
A	0008253	molecular_function	5'-nucleotidase activity
B	0000287	molecular_function	magnesium ion binding
B	0005737	cellular_component	cytoplasm
B	0008253	molecular_function	5'-nucleotidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PB A 903

Chain	Residue
A	ASP49
A	ASP238
A	SER239
A	ASP242
A	HOH905

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PB B 904

Chain	Residue
B	HOH1071
B	ASP49
B	ASP238
B	ASP242
B	HOH905

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EPE A 901

Chain	Residue
A	GLN294
A	LYS295
A	LEU297
A	HOH1061

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EPE B 902

Chain	Residue
B	GLN294
B	LYS295
B	LEU297
B	HOH1214
B	HOH1244
B	HOH1276
B	HOH1288

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"16672222","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"16672222","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16672222","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9W197","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---