Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2FZS

Crystal structure of E. coli ClpP with a Peptide Chloromethyl Ketone Covalently Bound at the Active Site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0008236	molecular_function	serine-type peptidase activity
A	0009266	biological_process	response to temperature stimulus
A	0009314	biological_process	response to radiation
A	0009368	cellular_component	endopeptidase Clp complex
A	0009376	cellular_component	HslUV protease complex
A	0009408	biological_process	response to heat
A	0010498	biological_process	proteasomal protein catabolic process
A	0016020	cellular_component	membrane
A	0042802	molecular_function	identical protein binding
A	0043068	biological_process	positive regulation of programmed cell death
A	0051117	molecular_function	ATPase binding
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0008236	molecular_function	serine-type peptidase activity
B	0009266	biological_process	response to temperature stimulus
B	0009314	biological_process	response to radiation
B	0009368	cellular_component	endopeptidase Clp complex
B	0009376	cellular_component	HslUV protease complex
B	0009408	biological_process	response to heat
B	0010498	biological_process	proteasomal protein catabolic process
B	0016020	cellular_component	membrane
B	0042802	molecular_function	identical protein binding
B	0043068	biological_process	positive regulation of programmed cell death
B	0051117	molecular_function	ATPase binding
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0008236	molecular_function	serine-type peptidase activity
C	0009266	biological_process	response to temperature stimulus
C	0009314	biological_process	response to radiation
C	0009368	cellular_component	endopeptidase Clp complex
C	0009376	cellular_component	HslUV protease complex
C	0009408	biological_process	response to heat
C	0010498	biological_process	proteasomal protein catabolic process
C	0016020	cellular_component	membrane
C	0042802	molecular_function	identical protein binding
C	0043068	biological_process	positive regulation of programmed cell death
C	0051117	molecular_function	ATPase binding
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0008236	molecular_function	serine-type peptidase activity
D	0009266	biological_process	response to temperature stimulus
D	0009314	biological_process	response to radiation
D	0009368	cellular_component	endopeptidase Clp complex
D	0009376	cellular_component	HslUV protease complex
D	0009408	biological_process	response to heat
D	0010498	biological_process	proteasomal protein catabolic process
D	0016020	cellular_component	membrane
D	0042802	molecular_function	identical protein binding
D	0043068	biological_process	positive regulation of programmed cell death
D	0051117	molecular_function	ATPase binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0008236	molecular_function	serine-type peptidase activity
E	0009266	biological_process	response to temperature stimulus
E	0009314	biological_process	response to radiation
E	0009368	cellular_component	endopeptidase Clp complex
E	0009376	cellular_component	HslUV protease complex
E	0009408	biological_process	response to heat
E	0010498	biological_process	proteasomal protein catabolic process
E	0016020	cellular_component	membrane
E	0042802	molecular_function	identical protein binding
E	0043068	biological_process	positive regulation of programmed cell death
E	0051117	molecular_function	ATPase binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0008236	molecular_function	serine-type peptidase activity
F	0009266	biological_process	response to temperature stimulus
F	0009314	biological_process	response to radiation
F	0009368	cellular_component	endopeptidase Clp complex
F	0009376	cellular_component	HslUV protease complex
F	0009408	biological_process	response to heat
F	0010498	biological_process	proteasomal protein catabolic process
F	0016020	cellular_component	membrane
F	0042802	molecular_function	identical protein binding
F	0043068	biological_process	positive regulation of programmed cell death
F	0051117	molecular_function	ATPase binding
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008236	molecular_function	serine-type peptidase activity
G	0009266	biological_process	response to temperature stimulus
G	0009314	biological_process	response to radiation
G	0009368	cellular_component	endopeptidase Clp complex
G	0009376	cellular_component	HslUV protease complex
G	0009408	biological_process	response to heat
G	0010498	biological_process	proteasomal protein catabolic process
G	0016020	cellular_component	membrane
G	0042802	molecular_function	identical protein binding
G	0043068	biological_process	positive regulation of programmed cell death
G	0051117	molecular_function	ATPase binding
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0008236	molecular_function	serine-type peptidase activity
H	0009266	biological_process	response to temperature stimulus
H	0009314	biological_process	response to radiation
H	0009368	cellular_component	endopeptidase Clp complex
H	0009376	cellular_component	HslUV protease complex
H	0009408	biological_process	response to heat
H	0010498	biological_process	proteasomal protein catabolic process
H	0016020	cellular_component	membrane
H	0042802	molecular_function	identical protein binding
H	0043068	biological_process	positive regulation of programmed cell death
H	0051117	molecular_function	ATPase binding
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008236	molecular_function	serine-type peptidase activity
I	0009266	biological_process	response to temperature stimulus
I	0009314	biological_process	response to radiation
I	0009368	cellular_component	endopeptidase Clp complex
I	0009376	cellular_component	HslUV protease complex
I	0009408	biological_process	response to heat
I	0010498	biological_process	proteasomal protein catabolic process
I	0016020	cellular_component	membrane
I	0042802	molecular_function	identical protein binding
I	0043068	biological_process	positive regulation of programmed cell death
I	0051117	molecular_function	ATPase binding
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0008236	molecular_function	serine-type peptidase activity
J	0009266	biological_process	response to temperature stimulus
J	0009314	biological_process	response to radiation
J	0009368	cellular_component	endopeptidase Clp complex
J	0009376	cellular_component	HslUV protease complex
J	0009408	biological_process	response to heat
J	0010498	biological_process	proteasomal protein catabolic process
J	0016020	cellular_component	membrane
J	0042802	molecular_function	identical protein binding
J	0043068	biological_process	positive regulation of programmed cell death
J	0051117	molecular_function	ATPase binding
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008236	molecular_function	serine-type peptidase activity
K	0009266	biological_process	response to temperature stimulus
K	0009314	biological_process	response to radiation
K	0009368	cellular_component	endopeptidase Clp complex
K	0009376	cellular_component	HslUV protease complex
K	0009408	biological_process	response to heat
K	0010498	biological_process	proteasomal protein catabolic process
K	0016020	cellular_component	membrane
K	0042802	molecular_function	identical protein binding
K	0043068	biological_process	positive regulation of programmed cell death
K	0051117	molecular_function	ATPase binding
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008236	molecular_function	serine-type peptidase activity
L	0009266	biological_process	response to temperature stimulus
L	0009314	biological_process	response to radiation
L	0009368	cellular_component	endopeptidase Clp complex
L	0009376	cellular_component	HslUV protease complex
L	0009408	biological_process	response to heat
L	0010498	biological_process	proteasomal protein catabolic process
L	0016020	cellular_component	membrane
L	0042802	molecular_function	identical protein binding
L	0043068	biological_process	positive regulation of programmed cell death
L	0051117	molecular_function	ATPase binding
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008236	molecular_function	serine-type peptidase activity
M	0009266	biological_process	response to temperature stimulus
M	0009314	biological_process	response to radiation
M	0009368	cellular_component	endopeptidase Clp complex
M	0009376	cellular_component	HslUV protease complex
M	0009408	biological_process	response to heat
M	0010498	biological_process	proteasomal protein catabolic process
M	0016020	cellular_component	membrane
M	0042802	molecular_function	identical protein binding
M	0043068	biological_process	positive regulation of programmed cell death
M	0051117	molecular_function	ATPase binding
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0008236	molecular_function	serine-type peptidase activity
N	0009266	biological_process	response to temperature stimulus
N	0009314	biological_process	response to radiation
N	0009368	cellular_component	endopeptidase Clp complex
N	0009376	cellular_component	HslUV protease complex
N	0009408	biological_process	response to heat
N	0010498	biological_process	proteasomal protein catabolic process
N	0016020	cellular_component	membrane
N	0042802	molecular_function	identical protein binding
N	0043068	biological_process	positive regulation of programmed cell death
N	0051117	molecular_function	ATPase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE CMQ A 501

Chain	Residue
A	GLY67
A	MET149
A	HOH4017
A	HOH4052
A	HOH4117
A	HOH4143
A	HOH4174
B	GOL3002
B	HOH4046
A	GLY68
A	VAL69
A	ILE70
A	SER97
A	MET98
A	HIS122
A	PRO124
A	LEU125

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CMQ B 502

Chain	Residue
B	GLY67
B	GLY68
B	VAL69
B	ILE70
B	SER97
B	MET98
B	HIS122
B	PRO124
B	LEU125
B	ILE142
B	MET149
B	HOH4017
B	HOH4021
B	HOH4129
C	GOL3005
C	HOH4091

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CMQ C 503

Chain	Residue
C	GLY67
C	GLY68
C	VAL69
C	ILE70
C	SER97
C	MET98
C	HIS122
C	PRO124
C	LEU125
C	ILE142
C	MET149
C	GOL3006
C	HOH4009
C	HOH4057
C	HOH4128

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CMQ D 504

Chain	Residue
D	GLY67
D	GLY68
D	VAL69
D	ILE70
D	SER97
D	MET98
D	HIS122
D	PRO124
D	LEU125
D	MET149
D	HOH4010
D	HOH4020
D	HOH4121
D	HOH4140

site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE CMQ E 505

Chain	Residue
E	GLY67
E	GLY68
E	VAL69
E	ILE70
E	SER97
E	MET98
E	HIS122
E	PRO124
E	LEU125
E	ILE142
E	MET149
E	HOH4012
E	HOH4018
E	HOH4102
E	HOH4152
F	ARG118
F	HOH4158

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CMQ F 506

Chain	Residue
F	GLY67
F	GLY68
F	VAL69
F	ILE70
F	SER97
F	MET98
F	HIS122
F	PRO124
F	LEU125
F	ILE142
F	MET149
F	HOH4032
F	HOH4045
F	HOH4077
F	HOH4167
G	GOL3009

site_id	AC7
Number of Residues	18
Details	BINDING SITE FOR RESIDUE CMQ G 507

Chain	Residue
G	VAL69
G	ILE70
G	SER97
G	MET98
G	HIS122
G	PRO124
G	LEU125
G	ILE142
G	MET149
G	HOH4038
G	HOH4043
G	HOH4086
G	HOH4090
G	HOH4221
A	ARG118
A	HOH4211
G	GLY67
G	GLY68

site_id	AC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CMQ H 508

Chain	Residue
H	GLY67
H	GLY68
H	VAL69
H	ILE70
H	SER97
H	MET98
H	HIS122
H	PRO124
H	LEU125
H	ILE142
H	MET149
H	HOH4021
H	HOH4037
H	HOH4076
H	HOH4086
N	GOL3007

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CMQ I 509

Chain	Residue
H	GOL3008
I	GLY67
I	GLY68
I	VAL69
I	ILE70
I	SER97
I	MET98
I	HIS122
I	PRO124
I	LEU125
I	ILE142
I	MET149
I	ASN150
I	HOH4016
I	HOH4051
I	HOH4126

site_id	BC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE CMQ J 510

Chain	Residue
I	HOH4063
J	GLY67
J	GLY68
J	VAL69
J	ILE70
J	SER97
J	MET98
J	HIS122
J	PRO124
J	LEU125
J	ILE142
J	VAL145
J	MET149
J	HOH4063
J	HOH4083
J	HOH4099
J	HOH4155
J	HOH4159
J	HOH4178
J	HOH4180

site_id	BC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE CMQ K 511

Chain	Residue
J	HOH4045
K	GLY67
K	GLY68
K	VAL69
K	ILE70
K	SER97
K	MET98
K	HIS122
K	PRO124
K	LEU125
K	GLU141
K	ILE142
K	MET149
K	HOH4021
K	HOH4029
K	HOH4053
K	HOH4134

site_id	BC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE CMQ L 512

Chain	Residue
E	HOH4122
K	GOL3010
L	GLY67
L	GLY68
L	VAL69
L	ILE70
L	SER97
L	MET98
L	HIS122
L	PRO124
L	LEU125
L	ILE142
L	MET149
L	HOH4015
L	HOH4025
L	HOH4079
L	HOH4248

site_id	BC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CMQ M 513

Chain	Residue
L	GOL3011
M	GLY67
M	GLY68
M	VAL69
M	ILE70
M	SER97
M	MET98
M	HIS122
M	PRO124
M	LEU125
M	ILE142
M	MET149
M	HOH4018
M	HOH4034
M	HOH4204

site_id	BC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE CMQ N 514

Chain	Residue
N	GLY67
N	GLY68
N	VAL69
N	ILE70
N	SER97
N	MET98
N	HIS122
N	PRO124
N	LEU125
N	ILE142
N	MET149
N	HOH4017
N	HOH4032
N	HOH4092
N	HOH4120
N	HOH4122
N	HOH4145

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE A 4001

Chain	Residue
A	TYR60
A	TYR62
A	ARG192
A	HOH4061
A	HOH4132
A	HOH4217

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE B 4002

Chain	Residue
B	GLU26
B	TYR62
B	ILE90
B	ARG192
B	ASN193
B	HOH4187

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGE C 4003

Chain	Residue
C	TYR62
C	ARG192
C	HOH4087

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE D 4004

Chain	Residue
D	TYR60
D	TYR62
D	PHE112
D	LEU189
D	ARG192
D	HOH4123

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGE E 4005

Chain	Residue
E	TYR60
E	ARG192
E	HOH4192

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGE F 4006

Chain	Residue
F	TYR60
F	TYR62
F	ARG192
F	HOH4103
F	HOH4201

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE G 4007

Chain	Residue
G	VAL28
G	TYR60
G	TYR62
G	ARG192
G	HOH4082
G	HOH4104

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE H 4008

Chain	Residue
H	TYR60
H	TYR62
H	LEU189
H	ARG192
H	HOH4127
H	HOH4165

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGE I 4009

Chain	Residue
I	TYR60
I	ILE90
I	ARG192

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE J 4010

Chain	Residue
J	TYR62
J	PHE112
J	LEU189
J	ARG192
J	HOH4124
J	HOH4171

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGE K 4011

Chain	Residue
K	TYR62
K	LEU189
K	ARG192

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE L 4012

Chain	Residue
L	TYR62
L	LEU189
L	ARG192
L	HOH4192

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE M 4013

Chain	Residue
M	VAL28
M	TYR62
M	LEU189
M	ARG192
M	HOH4059
M	HOH4210

site_id	DC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PGE N 4014

Chain	Residue
N	VAL28
N	TYR60
N	TYR62
N	ILE90
N	PHE112
N	LEU189
N	ARG192
N	HOH4132

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE K 4015

Chain	Residue
K	THR157
K	GLN159
K	TYR182
K	HOH4195
K	HOH4201
N	HOH4147

site_id	DC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 3001

Chain	Residue
A	ARG118
A	LEU174
A	SER175
A	HOH4124
A	HOH4125
A	HOH4230
G	GLU141
G	ARG148

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 3002

Chain	Residue
A	GLU141
A	CMQ501
B	GLN94
B	ARG118
B	PHE173

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 3003

Chain	Residue
B	THR157
B	GLN159
B	GLU181

site_id	DC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL F 3004

Chain	Residue
E	GLU141
E	LYS144
E	VAL145
F	ARG118
F	LEU174
F	SER175
F	HOH4028
F	HOH4054
F	HOH4191

site_id	DC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 3005

Chain	Residue
B	GLU141
B	CMQ502
C	GLN94
C	ARG118
C	MET120
C	PHE173
C	HOH4091
C	HOH4111

site_id	DC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 3006

Chain	Residue
C	THR71
C	GLU141
C	CMQ503
C	HOH4108
D	GLN94
D	ARG118
D	PHE173
D	HOH4147

site_id	DC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL N 3007

Chain	Residue
H	THR71
H	GLU141
H	CMQ508
N	GLN94
N	ARG118
N	PHE173

site_id	EC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL H 3008

Chain	Residue
H	GLN94
H	ARG118
H	HOH4097
H	HOH4135
I	GLU141
I	VAL145
I	CMQ509

site_id	EC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL G 3009

Chain	Residue
F	GLU141
F	CMQ506
G	GLN94
G	ARG118
G	PHE173
G	HOH4054
G	HOH4194

site_id	EC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL K 3010

Chain	Residue
K	GLN94
K	PHE173
K	HOH4104
L	GLU141
L	CMQ512

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL L 3011

Chain	Residue
L	GLN94
L	PHE173
L	HOH4202
L	HOH4240
M	GLU141
M	CMQ513

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TicMGqAASMGA

Chain	Residue	Details
A	THR89-ALA100

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RfclPnsrVMIHQP

Chain	Residue	Details
A	ARG111-PRO124

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	ACT_SITE: Nucleophile => ECO:0000305

Chain	Residue	Details
A	SER97
J	SER97
K	SER97
L	SER97
M	SER97
N	SER97
B	SER97
C	SER97
D	SER97
E	SER97
F	SER97
G	SER97
H	SER97
I	SER97

site_id	SWS_FT_FI2
Number of Residues	28
Details	ACT_SITE: ACT_SITE => ECO:0000305

Chain	Residue	Details
A	HIS122
E	ASP171
F	HIS122
F	ASP171
G	HIS122
G	ASP171
H	HIS122
H	ASP171
I	HIS122
I	ASP171
J	HIS122
A	ASP171
J	ASP171
K	HIS122
K	ASP171
L	HIS122
L	ASP171
M	HIS122
M	ASP171
N	HIS122
N	ASP171
B	HIS122
B	ASP171
C	HIS122
C	ASP171
D	HIS122
D	ASP171
E	HIS122

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
A	MET98
A	SER97
A	GLY68
A	HIS122
A	ASP171

site_id	CSA10
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
J	MET98
J	SER97
J	GLY68
J	HIS122
J	ASP171

site_id	CSA11
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
K	MET98
K	SER97
K	GLY68
K	HIS122
K	ASP171

site_id	CSA12
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
L	MET98
L	SER97
L	GLY68
L	HIS122
L	ASP171

site_id	CSA13
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
M	MET98
M	SER97
M	GLY68
M	HIS122
M	ASP171

site_id	CSA14
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
N	MET98
N	SER97
N	GLY68
N	HIS122
N	ASP171

site_id	CSA2
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
B	MET98
B	SER97
B	GLY68
B	HIS122
B	ASP171

site_id	CSA3
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
C	MET98
C	SER97
C	GLY68
C	HIS122
C	ASP171

site_id	CSA4
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
D	MET98
D	SER97
D	GLY68
D	HIS122
D	ASP171

site_id	CSA5
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
E	MET98
E	SER97
E	GLY68
E	HIS122
E	ASP171

site_id	CSA6
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
F	MET98
F	SER97
F	GLY68
F	HIS122
F	ASP171

site_id	CSA7
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
G	MET98
G	SER97
G	GLY68
G	HIS122
G	ASP171

site_id	CSA8
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
H	MET98
H	SER97
H	GLY68
H	HIS122
H	ASP171

site_id	CSA9
Number of Residues	5
Details	Annotated By Reference To The Literature 1tyf

Chain	Residue	Details
I	MET98
I	SER97
I	GLY68
I	HIS122
I	ASP171

site_id	MCSA1
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
A	GLY68	electrostatic stabiliser
A	SER97	covalent catalysis, proton shuttle (general acid/base)
A	MET98	electrostatic stabiliser
A	HIS122	proton shuttle (general acid/base)
A	ASP171	electrostatic stabiliser, modifies pKa

site_id	MCSA10
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
J	GLY68	electrostatic stabiliser
J	SER97	covalent catalysis, proton shuttle (general acid/base)
J	MET98	electrostatic stabiliser
J	HIS122	proton shuttle (general acid/base)
J	ASP171	electrostatic stabiliser, modifies pKa

site_id	MCSA11
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
K	GLY68	electrostatic stabiliser
K	SER97	covalent catalysis, proton shuttle (general acid/base)
K	MET98	electrostatic stabiliser
K	HIS122	proton shuttle (general acid/base)
K	ASP171	electrostatic stabiliser, modifies pKa

site_id	MCSA12
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
L	GLY68	electrostatic stabiliser
L	SER97	covalent catalysis, proton shuttle (general acid/base)
L	MET98	electrostatic stabiliser
L	HIS122	proton shuttle (general acid/base)
L	ASP171	electrostatic stabiliser, modifies pKa

site_id	MCSA13
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
M	GLY68	electrostatic stabiliser
M	SER97	covalent catalysis, proton shuttle (general acid/base)
M	MET98	electrostatic stabiliser
M	HIS122	proton shuttle (general acid/base)
M	ASP171	electrostatic stabiliser, modifies pKa

site_id	MCSA14
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
N	GLY68	electrostatic stabiliser
N	SER97	covalent catalysis, proton shuttle (general acid/base)
N	MET98	electrostatic stabiliser
N	HIS122	proton shuttle (general acid/base)
N	ASP171	electrostatic stabiliser, modifies pKa

site_id	MCSA2
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
B	GLY68	electrostatic stabiliser
B	SER97	covalent catalysis, proton shuttle (general acid/base)
B	MET98	electrostatic stabiliser
B	HIS122	proton shuttle (general acid/base)
B	ASP171	electrostatic stabiliser, modifies pKa

site_id	MCSA3
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
C	GLY68	electrostatic stabiliser
C	SER97	covalent catalysis, proton shuttle (general acid/base)
C	MET98	electrostatic stabiliser
C	HIS122	proton shuttle (general acid/base)
C	ASP171	electrostatic stabiliser, modifies pKa

site_id	MCSA4
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
D	GLY68	electrostatic stabiliser
D	SER97	covalent catalysis, proton shuttle (general acid/base)
D	MET98	electrostatic stabiliser
D	HIS122	proton shuttle (general acid/base)
D	ASP171	electrostatic stabiliser, modifies pKa

site_id	MCSA5
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
E	GLY68	electrostatic stabiliser
E	SER97	covalent catalysis, proton shuttle (general acid/base)
E	MET98	electrostatic stabiliser
E	HIS122	proton shuttle (general acid/base)
E	ASP171	electrostatic stabiliser, modifies pKa

site_id	MCSA6
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
F	GLY68	electrostatic stabiliser
F	SER97	covalent catalysis, proton shuttle (general acid/base)
F	MET98	electrostatic stabiliser
F	HIS122	proton shuttle (general acid/base)
F	ASP171	electrostatic stabiliser, modifies pKa

site_id	MCSA7
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
G	GLY68	electrostatic stabiliser
G	SER97	covalent catalysis, proton shuttle (general acid/base)
G	MET98	electrostatic stabiliser
G	HIS122	proton shuttle (general acid/base)
G	ASP171	electrostatic stabiliser, modifies pKa

site_id	MCSA8
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
H	GLY68	electrostatic stabiliser
H	SER97	covalent catalysis, proton shuttle (general acid/base)
H	MET98	electrostatic stabiliser
H	HIS122	proton shuttle (general acid/base)
H	ASP171	electrostatic stabiliser, modifies pKa

site_id	MCSA9
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
I	GLY68	electrostatic stabiliser
I	SER97	covalent catalysis, proton shuttle (general acid/base)
I	MET98	electrostatic stabiliser
I	HIS122	proton shuttle (general acid/base)
I	ASP171	electrostatic stabiliser, modifies pKa

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)