2FXF
Human spermidine/spermine N1-acetyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001525 | biological_process | angiogenesis |
| A | 0004145 | molecular_function | diamine N-acetyltransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006596 | biological_process | polyamine biosynthetic process |
| A | 0008080 | molecular_function | N-acetyltransferase activity |
| A | 0009447 | biological_process | putrescine catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0019809 | molecular_function | spermidine binding |
| A | 0032918 | biological_process | spermidine acetylation |
| A | 0042127 | biological_process | regulation of cell population proliferation |
| A | 0042802 | molecular_function | identical protein binding |
| B | 0001525 | biological_process | angiogenesis |
| B | 0004145 | molecular_function | diamine N-acetyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006596 | biological_process | polyamine biosynthetic process |
| B | 0008080 | molecular_function | N-acetyltransferase activity |
| B | 0009447 | biological_process | putrescine catabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0019809 | molecular_function | spermidine binding |
| B | 0032918 | biological_process | spermidine acetylation |
| B | 0042127 | biological_process | regulation of cell population proliferation |
| B | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 301 |
| Chain | Residue |
| A | GLU92 |
| A | ASP93 |
| A | HOH1001 |
| A | HOH1002 |
| A | HOH1003 |
| A | HOH1004 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 302 |
| Chain | Residue |
| B | HOH2022 |
| B | HOH2078 |
| B | HOH2081 |
| B | GLU92 |
| B | ASP93 |
| B | HOH2007 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA A 303 |
| Chain | Residue |
| A | CYS120 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA B 304 |
| Chain | Residue |
| B | ARG119 |
| B | CYS120 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 305 |
| Chain | Residue |
| A | ALA12 |
| A | SER15 |
| A | HOH1082 |
| A | HOH1111 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 801 |
| Chain | Residue |
| A | GLU28 |
| A | VAL129 |
| A | ALA130 |
| A | ASN133 |
| A | ACO1000 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ACO A 1000 |
| Chain | Residue |
| A | TYR27 |
| A | GLU92 |
| A | PHE94 |
| A | PHE95 |
| A | VAL96 |
| A | ARG101 |
| A | GLY102 |
| A | PHE103 |
| A | GLY104 |
| A | ILE105 |
| A | GLY106 |
| A | SER107 |
| A | ASN133 |
| A | SER136 |
| A | PHE139 |
| A | TYR140 |
| A | ARG142 |
| A | ARG143 |
| A | ACT801 |
| A | HOH1010 |
| A | HOH1068 |
| A | HOH1128 |
| site_id | AC8 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE ACO B 2000 |
| Chain | Residue |
| B | TYR27 |
| B | GLU92 |
| B | PHE94 |
| B | PHE95 |
| B | VAL96 |
| B | ARG101 |
| B | ARG101 |
| B | GLY102 |
| B | PHE103 |
| B | GLY104 |
| B | ILE105 |
| B | GLY106 |
| B | SER107 |
| B | LEU128 |
| B | ASN133 |
| B | PRO135 |
| B | SER136 |
| B | TYR140 |
| B | ARG142 |
| B | ARG143 |
| B | HOH2009 |
| B | HOH2050 |
| B | HOH2050 |
| B | HOH2068 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P0A951","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 35 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17516632","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
