Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 100 |
| Chain | Residue |
| A | PRO1 |
| A | LYS55 |
| A | HOH149 |
| B | GLY68 |
| B | HIS69 |
| B | LYS70 |
| B | HOH188 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 100 |
| Chain | Residue |
| B | HIS69 |
| B | HOH165 |
| B | PRO1 |
| B | ARG57 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 101 |
| Chain | Residue |
| A | DR7102 |
| B | ARG8 |
| B | HOH147 |
| B | HOH185 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT A 101 |
| Chain | Residue |
| A | LYS14 |
| A | GLY16 |
| A | GLY17 |
| A | HOH116 |
| A | HOH153 |
| A | HOH210 |
| B | LYS14 |
| B | GLY17 |
| site_id | AC5 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE DR7 A 102 |
| Chain | Residue |
| A | TRP6 |
| A | ARG8 |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | GLY48 |
| A | GLY49 |
| A | ILE50 |
| A | PHE53 |
| A | PRO81 |
| A | VAL82 |
| A | ILE84 |
| A | HOH105 |
| A | HOH173 |
| A | HOH174 |
| A | HOH207 |
| B | ARG8 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | GLY48 |
| B | GLY49 |
| B | ILE50 |
| B | PRO81 |
| B | VAL82 |
| B | ILE84 |
| B | SO4101 |
| B | HOH130 |
| B | HOH156 |
| B | HOH161 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 102 |
| Chain | Residue |
| B | VAL11 |
| B | THR12 |
| B | LYS41 |
| B | TRP42 |
| B | ALA67 |
| B | HOH201 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 103 |
| Chain | Residue |
| A | LYS7 |
| A | ARG8 |
| A | HOH123 |
| A | HOH192 |
| B | ARG87 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| A | THR26 | |
| B | ASP25 | |
| B | THR26 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| B | ASP25 | |
