2FU6

Zinc-beta-lactamase l1 from stenotrophomonas maltophilia (apo form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
B	0008270	molecular_function	zinc ion binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0042597	cellular_component	periplasmic space
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 4

Chain	Residue
B	ARG172
B	ILE180
B	THR181
B	HOH331

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 5

Chain	Residue
A	GOL3
A	ARG172
A	VAL179
A	ILE180
A	THR181

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 A 6

Chain	Residue
A	SO411
A	ARG252
A	LYS297
B	ARG209
B	ALA275
B	ARG276
B	ALA289
B	GLY290
B	ALA291
B	HOH395
B	HOH450

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 7

Chain	Residue
A	ALA275
A	ARG288
A	ALA289
A	GLY290
A	ALA291
A	HOH411
B	ARG252

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 8

Chain	Residue
A	ARG102
A	ASN210
A	HOH347
A	HOH528

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 9

Chain	Residue
A	ARG252
B	ARG209

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 10

Chain	Residue
B	ARG102
B	GLY211

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 11

Chain	Residue
A	SO46
A	ARG252
B	ALA275
B	ARG276

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 1

Chain	Residue
A	HOH459
B	ASP152
B	ALA170
B	HOH383
B	HOH505
B	HOH521

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 2

Chain	Residue
A	ASP152
A	ASP171
A	HOH394
B	HOH483

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 3

Chain	Residue
A	SO45
A	ARG110
A	ARG172
A	THR181

---

Functional Information from PROSITE/UniProt

site_id	PS00743
Number of Residues	21
Details	BETA_LACTAMASE_B_1 Beta-lactamases class B signature 1. LlSHaHADhaGPvaelkrrtG

Chain	Residue	Details
A	LEU113-GLY133

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17999929","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9811546","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P25910","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9811546","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1qh5

Chain	Residue	Details
A	ASP120

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1qh5

Chain	Residue	Details
B	ASP120

---

site_id	MCSA1
Number of Residues	7
Details	M-CSA 258

Chain	Residue	Details
A	HIS116	metal ligand
A	HIS118	metal ligand
A	ASP120	metal ligand
A	HIS121	metal ligand
A	HIS196	metal ligand
A	TYR229	electrostatic stabiliser, hydrogen bond donor
A	HIS263	metal ligand

---

site_id	MCSA2
Number of Residues	7
Details	M-CSA 258

Chain	Residue	Details
B	HIS116	metal ligand
B	HIS118	metal ligand
B	ASP120	metal ligand
B	HIS121	metal ligand
B	HIS196	metal ligand
B	TYR229	electrostatic stabiliser, hydrogen bond donor
B	HIS263	metal ligand

---