2FM1
Crystal structure of L-ALLO-threonine aldolase (tm1744) from Thermotoga maritima at 2.25 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006545 | biological_process | glycine biosynthetic process |
| A | 0006567 | biological_process | L-threonine catabolic process |
| A | 0008732 | molecular_function | L-allo-threonine aldolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006545 | biological_process | glycine biosynthetic process |
| B | 0006567 | biological_process | L-threonine catabolic process |
| B | 0008732 | molecular_function | L-allo-threonine aldolase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006545 | biological_process | glycine biosynthetic process |
| C | 0006567 | biological_process | L-threonine catabolic process |
| C | 0008732 | molecular_function | L-allo-threonine aldolase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0006545 | biological_process | glycine biosynthetic process |
| D | 0006567 | biological_process | L-threonine catabolic process |
| D | 0008732 | molecular_function | L-allo-threonine aldolase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 344 |
| Chain | Residue |
| A | ASN288 |
| A | SER343 |
| A | HOH510 |
| D | ASN326 |
| D | GLU329 |
| D | HOH379 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 345 |
| Chain | Residue |
| C | GLU329 |
| C | HOH453 |
| C | HOH477 |
| C | HOH531 |
| A | ASP322 |
| A | HOH459 |
| C | ASN326 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA D 344 |
| Chain | Residue |
| D | THR286 |
| D | LEU289 |
| D | VAL291 |
| D | HOH417 |
| D | HOH461 |
| D | HOH563 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 344 |
| Chain | Residue |
| B | VAL25 |
| C | LYS11 |
| C | ARG17 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 346 |
| Chain | Residue |
| A | GLN71 |
| A | ARG72 |
| A | HOH462 |
| C | GLN71 |
| C | ARG72 |
| C | HOH535 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 347 |
| Chain | Residue |
| A | GLU24 |
| A | VAL25 |
| D | LYS11 |
| D | ARG17 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL D 345 |
| Chain | Residue |
| B | GLN71 |
| B | ARG72 |
| B | HOH502 |
| B | HOH573 |
| D | GLN71 |
| D | ARG72 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 345 |
| Chain | Residue |
| B | ARG144 |
| B | VAL145 |
| B | LYS278 |
| B | HOH391 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 346 |
| Chain | Residue |
| B | LYS11 |
| B | ARG17 |
| C | VAL25 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 348 |
| Chain | Residue |
| A | LYS11 |
| A | ARG17 |
| D | VAL25 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 344 |
| Chain | Residue |
| A | LYS221 |
| C | ILE124 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 345 |
| Chain | Residue |
| C | ARG144 |
| C | VAL145 |
| C | LYS278 |
| C | HOH546 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL D 346 |
| Chain | Residue |
| D | ARG144 |
| D | VAL145 |
| D | LYS278 |
| D | HOH423 |
| D | HOH456 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 346 |
| Chain | Residue |
| C | LYS49 |
| C | GLY188 |
| C | ALA190 |
| C | ASP191 |
| C | HOH616 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | TYR30 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | HIS83 | |
| B | ASP168 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | HIS83 | |
| C | ASP168 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | HIS83 | |
| D | ASP168 |
| site_id | CSA13 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | GLU135 | |
| A | HIS83 | |
| A | ASP168 |
| site_id | CSA14 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | GLU135 | |
| B | HIS83 | |
| B | ASP168 |
| site_id | CSA15 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | GLU135 | |
| C | HIS83 | |
| C | ASP168 |
| site_id | CSA16 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | GLU135 | |
| D | HIS83 | |
| D | ASP168 |
| site_id | CSA17 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | PHE85 | |
| A | ASP168 |
| site_id | CSA18 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | PHE85 | |
| B | ASP168 |
| site_id | CSA19 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | PHE85 | |
| C | ASP168 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | TYR30 |
| site_id | CSA20 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | PHE85 | |
| D | ASP168 |
| site_id | CSA21 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | GLU32 |
| site_id | CSA22 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | GLU32 |
| site_id | CSA23 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | GLU32 |
| site_id | CSA24 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | GLU32 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | TYR30 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | TYR30 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | TRP86 | |
| A | ASP168 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | TRP86 | |
| B | ASP168 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | TRP86 | |
| C | ASP168 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | TRP86 | |
| D | ASP168 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | HIS83 | |
| A | ASP168 |
