2FK3
Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'large unit cell' form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
| A | 0046914 | molecular_function | transition metal ion binding |
| B | 0016020 | cellular_component | membrane |
| B | 0046914 | molecular_function | transition metal ion binding |
| C | 0016020 | cellular_component | membrane |
| C | 0046914 | molecular_function | transition metal ion binding |
| D | 0016020 | cellular_component | membrane |
| D | 0046914 | molecular_function | transition metal ion binding |
| E | 0016020 | cellular_component | membrane |
| E | 0046914 | molecular_function | transition metal ion binding |
| F | 0016020 | cellular_component | membrane |
| F | 0046914 | molecular_function | transition metal ion binding |
| G | 0016020 | cellular_component | membrane |
| G | 0046914 | molecular_function | transition metal ion binding |
| H | 0016020 | cellular_component | membrane |
| H | 0046914 | molecular_function | transition metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CU C 201 |
| Chain | Residue |
| C | HIS137 |
| G | HIS137 |
| G | HOH190 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CU C 202 |
| Chain | Residue |
| C | GLU131 |
| H | HIS137 |
| H | GLU139 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CU B 203 |
| Chain | Residue |
| B | HIS137 |
| D | HIS137 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU A 204 |
| Chain | Residue |
| A | GLU139 |
| A | HOH237 |
| G | GLU131 |
| A | HIS137 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU E 205 |
| Chain | Residue |
| D | GLU131 |
| E | HIS137 |
| E | GLU139 |
| E | HOH238 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CU F 206 |
| Chain | Residue |
| B | GLU131 |
| F | HIS137 |
| F | GLU139 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CU H 207 |
| Chain | Residue |
| E | HOH224 |
| E | HOH225 |
| E | HOH226 |
| H | HOH212 |
| H | HOH213 |
| H | HOH214 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CU A 208 |
| Chain | Residue |
| A | HOH214 |
| A | HOH217 |
| A | HOH218 |
| F | HOH220 |
| F | HOH221 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU H 209 |
| Chain | Residue |
| H | HOH223 |
| H | HOH224 |
| H | HOH231 |
| H | HOH232 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CU C 210 |
| Chain | Residue |
| C | HOH244 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CU A 211 |
| Chain | Residue |
| A | HOH235 |
| A | HOH236 |
| A | HOH237 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CU E 212 |
| Chain | Residue |
| E | LEU165 |
| E | HIS166 |
| H | LEU165 |
| H | HIS166 |
| H | HOH213 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU A 213 |
| Chain | Residue |
| A | LEU165 |
| A | HIS166 |
| F | LEU165 |
| F | HIS166 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CU B 214 |
| Chain | Residue |
| B | TYR168 |
| C | TYR168 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU D 215 |
| Chain | Residue |
| D | TYR168 |
| D | HOH229 |
| G | TYR168 |
| G | HOH209 |
| site_id | BC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CU D 216 |
| Chain | Residue |
| E | HOH221 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU F 217 |
| Chain | Residue |
| F | SER159 |
| F | THR163 |
| F | ASN164 |
| F | HOH222 |
| site_id | BC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CU F 219 |
| Chain | Residue |
| A | HOH227 |
Functional Information from PROSITE/UniProt
| site_id | PS00319 |
| Number of Residues | 8 |
| Details | APP_CUBD Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. GVEFVCCP |
| Chain | Residue | Details |
| A | GLY181-PRO188 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 348 |
| Details | Region: {"description":"CuBD subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01217","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01217","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17239395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25122912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FK1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01217","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17239395","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FK1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8344894","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Site: {"description":"Required for Cu(2+) reduction","evidences":[{"source":"PROSITE-ProRule","id":"PRU01217","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
