2FJZ
Structure of the Alzheimer's Amyloid Precursor Protein (APP) copper binding domain (residues 133 to 189) in 'small unit cell' form, metal-free
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00319 |
| Number of Residues | 8 |
| Details | APP_CUBD Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. GVEFVCCP |
| Chain | Residue | Details |
| A | GLY181-PRO188 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 58 |
| Details | Region: {"description":"CuBD subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01217","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01217","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17239395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25122912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FK1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01217","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17239395","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FK1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8344894","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required for Cu(2+) reduction","evidences":[{"source":"PROSITE-ProRule","id":"PRU01217","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
