Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2FG8

Structure of Human Ferritin L Chain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005776	cellular_component	autophagosome
A	0005829	cellular_component	cytosol
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0016020	cellular_component	membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0035578	cellular_component	azurophil granule lumen
A	0042802	molecular_function	identical protein binding
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0055072	biological_process	obsolete iron ion homeostasis
A	0070062	cellular_component	extracellular exosome
A	0070288	cellular_component	ferritin complex
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005776	cellular_component	autophagosome
B	0005829	cellular_component	cytosol
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0008198	molecular_function	ferrous iron binding
B	0008199	molecular_function	ferric iron binding
B	0016020	cellular_component	membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0035578	cellular_component	azurophil granule lumen
B	0042802	molecular_function	identical protein binding
B	0044754	cellular_component	autolysosome
B	0046872	molecular_function	metal ion binding
B	0055072	biological_process	obsolete iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0070288	cellular_component	ferritin complex
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005776	cellular_component	autophagosome
C	0005829	cellular_component	cytosol
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0008198	molecular_function	ferrous iron binding
C	0008199	molecular_function	ferric iron binding
C	0016020	cellular_component	membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0035578	cellular_component	azurophil granule lumen
C	0042802	molecular_function	identical protein binding
C	0044754	cellular_component	autolysosome
C	0046872	molecular_function	metal ion binding
C	0055072	biological_process	obsolete iron ion homeostasis
C	0070062	cellular_component	extracellular exosome
C	0070288	cellular_component	ferritin complex
D	0005506	molecular_function	iron ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005776	cellular_component	autophagosome
D	0005829	cellular_component	cytosol
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0008198	molecular_function	ferrous iron binding
D	0008199	molecular_function	ferric iron binding
D	0016020	cellular_component	membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0035578	cellular_component	azurophil granule lumen
D	0042802	molecular_function	identical protein binding
D	0044754	cellular_component	autolysosome
D	0046872	molecular_function	metal ion binding
D	0055072	biological_process	obsolete iron ion homeostasis
D	0070062	cellular_component	extracellular exosome
D	0070288	cellular_component	ferritin complex
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0005776	cellular_component	autophagosome
E	0005829	cellular_component	cytosol
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0008198	molecular_function	ferrous iron binding
E	0008199	molecular_function	ferric iron binding
E	0016020	cellular_component	membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0035578	cellular_component	azurophil granule lumen
E	0042802	molecular_function	identical protein binding
E	0044754	cellular_component	autolysosome
E	0046872	molecular_function	metal ion binding
E	0055072	biological_process	obsolete iron ion homeostasis
E	0070062	cellular_component	extracellular exosome
E	0070288	cellular_component	ferritin complex
F	0005506	molecular_function	iron ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005737	cellular_component	cytoplasm
F	0005776	cellular_component	autophagosome
F	0005829	cellular_component	cytosol
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0008198	molecular_function	ferrous iron binding
F	0008199	molecular_function	ferric iron binding
F	0016020	cellular_component	membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0035578	cellular_component	azurophil granule lumen
F	0042802	molecular_function	identical protein binding
F	0044754	cellular_component	autolysosome
F	0046872	molecular_function	metal ion binding
F	0055072	biological_process	obsolete iron ion homeostasis
F	0070062	cellular_component	extracellular exosome
F	0070288	cellular_component	ferritin complex
G	0005506	molecular_function	iron ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005737	cellular_component	cytoplasm
G	0005776	cellular_component	autophagosome
G	0005829	cellular_component	cytosol
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0008198	molecular_function	ferrous iron binding
G	0008199	molecular_function	ferric iron binding
G	0016020	cellular_component	membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0035578	cellular_component	azurophil granule lumen
G	0042802	molecular_function	identical protein binding
G	0044754	cellular_component	autolysosome
G	0046872	molecular_function	metal ion binding
G	0055072	biological_process	obsolete iron ion homeostasis
G	0070062	cellular_component	extracellular exosome
G	0070288	cellular_component	ferritin complex
H	0005506	molecular_function	iron ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005737	cellular_component	cytoplasm
H	0005776	cellular_component	autophagosome
H	0005829	cellular_component	cytosol
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0008198	molecular_function	ferrous iron binding
H	0008199	molecular_function	ferric iron binding
H	0016020	cellular_component	membrane
H	0031410	cellular_component	cytoplasmic vesicle
H	0035578	cellular_component	azurophil granule lumen
H	0042802	molecular_function	identical protein binding
H	0044754	cellular_component	autolysosome
H	0046872	molecular_function	metal ion binding
H	0055072	biological_process	obsolete iron ion homeostasis
H	0070062	cellular_component	extracellular exosome
H	0070288	cellular_component	ferritin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CS E 201

Chain	Residue
D	ASP131
D	GLU134
E	ASP131
E	GLU134
H	ASP131
H	GLU134

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CS A 202

Chain	Residue
B	GLU134
C	ASP131
C	GLU134
C	CS205
A	ASP131
A	GLU134
B	ASP131

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS D 203

Chain	Residue
D	ASP131
E	THR135

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS A 204

Chain	Residue
A	GLU134
C	GLU134

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS C 205

Chain	Residue
A	CS202
C	THR135

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS E 206

Chain	Residue
E	GLU134
H	GLU134

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CS F 207

Chain	Residue
F	ASP131
F	ASP131
F	ASP131
F	GLU134
F	GLU134
F	GLU134

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CS F 208

Chain	Residue
F	ASP131
F	ASP131
F	ASP131

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CS G 210

Chain	Residue
G	ASP131
G	ASP131
G	ASP131

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFLEthFLdeevklIK

Chain	Residue	Details
A	ASP126-LYS146

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EkREgyERLLkmQNqRgGR

Chain	Residue	Details
A	GLU61-ARG79

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1192
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	56
Details	Region: {"description":"Catalytic site for iron oxidation"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	40
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"6653779","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)