2FB3
Structure of MoaA in complex with 5'-GTP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0006777 | biological_process | Mo-molybdopterin cofactor biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0032324 | biological_process | molybdopterin cofactor biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| A | 0061798 | molecular_function | GTP 3',8'-cyclase activity |
| A | 0061799 | molecular_function | cyclic pyranopterin monophosphate synthase activity |
| A | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0006777 | biological_process | Mo-molybdopterin cofactor biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0032324 | biological_process | molybdopterin cofactor biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051536 | molecular_function | iron-sulfur cluster binding |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| B | 0061798 | molecular_function | GTP 3',8'-cyclase activity |
| B | 0061799 | molecular_function | cyclic pyranopterin monophosphate synthase activity |
| B | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 403 |
| Chain | Residue |
| A | CYS28 |
| A | TYR30 |
| A | SER126 |
| A | LEU127 |
| A | ASP128 |
| A | PHE135 |
| A | HOH585 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 403 |
| Chain | Residue |
| B | LEU127 |
| B | ASP128 |
| B | CYS28 |
| B | SER126 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MET A 500 |
| Chain | Residue |
| A | THR73 |
| A | GLY75 |
| A | GLU76 |
| A | THR102 |
| A | THR103 |
| A | SER126 |
| A | SF4401 |
| A | 5AD501 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MET B 501 |
| Chain | Residue |
| B | GLY75 |
| B | GLU76 |
| B | THR102 |
| B | THR103 |
| B | ASN104 |
| B | SER126 |
| B | SF4401 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SF4 A 401 |
| Chain | Residue |
| A | CYS24 |
| A | PHE26 |
| A | CYS28 |
| A | CYS31 |
| A | MET500 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SF4 A 402 |
| Chain | Residue |
| A | CYS261 |
| A | CYS264 |
| A | CYS278 |
| A | TYR316 |
| A | SER317 |
| A | GTP404 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GTP A 404 |
| Chain | Residue |
| A | ARG17 |
| A | LYS69 |
| A | ARG71 |
| A | THR102 |
| A | ASN124 |
| A | LYS163 |
| A | ASN165 |
| A | ARG192 |
| A | PHE260 |
| A | ARG266 |
| A | ARG268 |
| A | SF4402 |
| A | 5AD501 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 5AD A 501 |
| Chain | Residue |
| A | TYR30 |
| A | SER126 |
| A | VAL167 |
| A | MET197 |
| A | GTP404 |
| A | MET500 |
| A | HOH532 |
| A | HOH585 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SF4 B 401 |
| Chain | Residue |
| B | CYS24 |
| B | PHE26 |
| B | CYS28 |
| B | CYS31 |
| B | MET32 |
| B | GLY75 |
| B | ASN104 |
| B | MET501 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SF4 B 402 |
| Chain | Residue |
| B | CYS261 |
| B | CYS264 |
| B | CYS278 |
| B | ASP314 |
| B | TYR316 |
| B | SER317 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE POP B 404 |
| Chain | Residue |
| B | ARG71 |
| B | ASN124 |
| B | ARG192 |
| B | HOH531 |
Functional Information from PROSITE/UniProt
| site_id | PS01305 |
| Number of Residues | 12 |
| Details | MOAA_NIFB_PQQE moaA / nifB / pqqE family signature. VtdrCNFRCdYC |
| Chain | Residue | Details |
| A | VAL20-CYS31 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 438 |
| Details | Domain: {"description":"Radical SAM core","evidences":[{"source":"PROSITE-ProRule","id":"PRU01266","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16632608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FB3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
