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2F80

HIV-1 Protease mutant D30N complexed with inhibitor TMC114

Functional Information from GO Data
ChainGOidnamespacecontents
A0004190molecular_functionaspartic-type endopeptidase activity
A0006508biological_processproteolysis
B0004190molecular_functionaspartic-type endopeptidase activity
B0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 401
ChainResidue
ATHR74
AASN88
AHOH1078
BARG41

site_idAC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL B 402
ChainResidue
BTRP6

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 403
ChainResidue
BHOH1015
ALYS45
AMET46
AHOH1067
BGLN92

site_idAC4
Number of Residues27
DetailsBINDING SITE FOR RESIDUE 017 B 301
ChainResidue
ALEU23
AASP25
AGLY27
AALA28
AASP29
AASN30
AVAL32
AGLY48
AGLY49
AILE50
APRO81
AVAL82
AILE84
BASP25
BGLY27
BALA28
BASP29
BASN30
BVAL32
BGLY48
BGLY49
BILE50
BPRO81
BVAL82
BILE84
BHOH1120
BHOH1123

Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADNTVI
ChainResidueDetails
AALA22-ILE33

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues138
DetailsDomain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues20
DetailsRegion: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsActive site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1a30
ChainResidueDetails
AASP25
ATHR26
BASP25
BTHR26

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a30
ChainResidueDetails
AASP25
BASP25

239492

PDB entries from 2025-07-30

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