2F73

Crystal structure of human fatty acid binding protein 1 (FABP1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003682	molecular_function	chromatin binding
A	0005319	molecular_function	lipid transporter activity
A	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
A	0005504	molecular_function	fatty acid binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0006869	biological_process	lipid transport
A	0008289	molecular_function	lipid binding
A	0015485	molecular_function	cholesterol binding
A	0015908	biological_process	fatty acid transport
A	0015909	biological_process	long-chain fatty acid transport
A	0016209	molecular_function	antioxidant activity
A	0019216	biological_process	regulation of lipid metabolic process
A	0019433	biological_process	triglyceride catabolic process
A	0032934	molecular_function	sterol binding
A	0036042	molecular_function	long-chain fatty acyl-CoA binding
A	0042167	biological_process	heme catabolic process
A	0070062	cellular_component	extracellular exosome
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0071456	biological_process	cellular response to hypoxia
A	0098869	biological_process	cellular oxidant detoxification
A	0120009	biological_process	intermembrane lipid transfer
A	0120013	molecular_function	lipid transfer activity
A	0140104	molecular_function	molecular carrier activity
A	1990748	biological_process	cellular detoxification
B	0003682	molecular_function	chromatin binding
B	0005319	molecular_function	lipid transporter activity
B	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
B	0005504	molecular_function	fatty acid binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005782	cellular_component	peroxisomal matrix
B	0005829	cellular_component	cytosol
B	0006869	biological_process	lipid transport
B	0008289	molecular_function	lipid binding
B	0015485	molecular_function	cholesterol binding
B	0015908	biological_process	fatty acid transport
B	0015909	biological_process	long-chain fatty acid transport
B	0016209	molecular_function	antioxidant activity
B	0019216	biological_process	regulation of lipid metabolic process
B	0019433	biological_process	triglyceride catabolic process
B	0032934	molecular_function	sterol binding
B	0036042	molecular_function	long-chain fatty acyl-CoA binding
B	0042167	biological_process	heme catabolic process
B	0070062	cellular_component	extracellular exosome
B	0070301	biological_process	cellular response to hydrogen peroxide
B	0071456	biological_process	cellular response to hypoxia
B	0098869	biological_process	cellular oxidant detoxification
B	0120009	biological_process	intermembrane lipid transfer
B	0120013	molecular_function	lipid transfer activity
B	0140104	molecular_function	molecular carrier activity
B	1990748	biological_process	cellular detoxification
C	0003682	molecular_function	chromatin binding
C	0005319	molecular_function	lipid transporter activity
C	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
C	0005504	molecular_function	fatty acid binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005782	cellular_component	peroxisomal matrix
C	0005829	cellular_component	cytosol
C	0006869	biological_process	lipid transport
C	0008289	molecular_function	lipid binding
C	0015485	molecular_function	cholesterol binding
C	0015908	biological_process	fatty acid transport
C	0015909	biological_process	long-chain fatty acid transport
C	0016209	molecular_function	antioxidant activity
C	0019216	biological_process	regulation of lipid metabolic process
C	0019433	biological_process	triglyceride catabolic process
C	0032934	molecular_function	sterol binding
C	0036042	molecular_function	long-chain fatty acyl-CoA binding
C	0042167	biological_process	heme catabolic process
C	0070062	cellular_component	extracellular exosome
C	0070301	biological_process	cellular response to hydrogen peroxide
C	0071456	biological_process	cellular response to hypoxia
C	0098869	biological_process	cellular oxidant detoxification
C	0120009	biological_process	intermembrane lipid transfer
C	0120013	molecular_function	lipid transfer activity
C	0140104	molecular_function	molecular carrier activity
C	1990748	biological_process	cellular detoxification
D	0003682	molecular_function	chromatin binding
D	0005319	molecular_function	lipid transporter activity
D	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
D	0005504	molecular_function	fatty acid binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005782	cellular_component	peroxisomal matrix
D	0005829	cellular_component	cytosol
D	0006869	biological_process	lipid transport
D	0008289	molecular_function	lipid binding
D	0015485	molecular_function	cholesterol binding
D	0015908	biological_process	fatty acid transport
D	0015909	biological_process	long-chain fatty acid transport
D	0016209	molecular_function	antioxidant activity
D	0019216	biological_process	regulation of lipid metabolic process
D	0019433	biological_process	triglyceride catabolic process
D	0032934	molecular_function	sterol binding
D	0036042	molecular_function	long-chain fatty acyl-CoA binding
D	0042167	biological_process	heme catabolic process
D	0070062	cellular_component	extracellular exosome
D	0070301	biological_process	cellular response to hydrogen peroxide
D	0071456	biological_process	cellular response to hypoxia
D	0098869	biological_process	cellular oxidant detoxification
D	0120009	biological_process	intermembrane lipid transfer
D	0120013	molecular_function	lipid transfer activity
D	0140104	molecular_function	molecular carrier activity
D	1990748	biological_process	cellular detoxification
E	0003682	molecular_function	chromatin binding
E	0005319	molecular_function	lipid transporter activity
E	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
E	0005504	molecular_function	fatty acid binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005782	cellular_component	peroxisomal matrix
E	0005829	cellular_component	cytosol
E	0006869	biological_process	lipid transport
E	0008289	molecular_function	lipid binding
E	0015485	molecular_function	cholesterol binding
E	0015908	biological_process	fatty acid transport
E	0015909	biological_process	long-chain fatty acid transport
E	0016209	molecular_function	antioxidant activity
E	0019216	biological_process	regulation of lipid metabolic process
E	0019433	biological_process	triglyceride catabolic process
E	0032934	molecular_function	sterol binding
E	0036042	molecular_function	long-chain fatty acyl-CoA binding
E	0042167	biological_process	heme catabolic process
E	0070062	cellular_component	extracellular exosome
E	0070301	biological_process	cellular response to hydrogen peroxide
E	0071456	biological_process	cellular response to hypoxia
E	0098869	biological_process	cellular oxidant detoxification
E	0120009	biological_process	intermembrane lipid transfer
E	0120013	molecular_function	lipid transfer activity
E	0140104	molecular_function	molecular carrier activity
E	1990748	biological_process	cellular detoxification
F	0003682	molecular_function	chromatin binding
F	0005319	molecular_function	lipid transporter activity
F	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
F	0005504	molecular_function	fatty acid binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005782	cellular_component	peroxisomal matrix
F	0005829	cellular_component	cytosol
F	0006869	biological_process	lipid transport
F	0008289	molecular_function	lipid binding
F	0015485	molecular_function	cholesterol binding
F	0015908	biological_process	fatty acid transport
F	0015909	biological_process	long-chain fatty acid transport
F	0016209	molecular_function	antioxidant activity
F	0019216	biological_process	regulation of lipid metabolic process
F	0019433	biological_process	triglyceride catabolic process
F	0032934	molecular_function	sterol binding
F	0036042	molecular_function	long-chain fatty acyl-CoA binding
F	0042167	biological_process	heme catabolic process
F	0070062	cellular_component	extracellular exosome
F	0070301	biological_process	cellular response to hydrogen peroxide
F	0071456	biological_process	cellular response to hypoxia
F	0098869	biological_process	cellular oxidant detoxification
F	0120009	biological_process	intermembrane lipid transfer
F	0120013	molecular_function	lipid transfer activity
F	0140104	molecular_function	molecular carrier activity
F	1990748	biological_process	cellular detoxification
G	0003682	molecular_function	chromatin binding
G	0005319	molecular_function	lipid transporter activity
G	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
G	0005504	molecular_function	fatty acid binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005782	cellular_component	peroxisomal matrix
G	0005829	cellular_component	cytosol
G	0006869	biological_process	lipid transport
G	0008289	molecular_function	lipid binding
G	0015485	molecular_function	cholesterol binding
G	0015908	biological_process	fatty acid transport
G	0015909	biological_process	long-chain fatty acid transport
G	0016209	molecular_function	antioxidant activity
G	0019216	biological_process	regulation of lipid metabolic process
G	0019433	biological_process	triglyceride catabolic process
G	0032934	molecular_function	sterol binding
G	0036042	molecular_function	long-chain fatty acyl-CoA binding
G	0042167	biological_process	heme catabolic process
G	0070062	cellular_component	extracellular exosome
G	0070301	biological_process	cellular response to hydrogen peroxide
G	0071456	biological_process	cellular response to hypoxia
G	0098869	biological_process	cellular oxidant detoxification
G	0120009	biological_process	intermembrane lipid transfer
G	0120013	molecular_function	lipid transfer activity
G	0140104	molecular_function	molecular carrier activity
G	1990748	biological_process	cellular detoxification
H	0003682	molecular_function	chromatin binding
H	0005319	molecular_function	lipid transporter activity
H	0005324	molecular_function	long-chain fatty acid transmembrane transporter activity
H	0005504	molecular_function	fatty acid binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005782	cellular_component	peroxisomal matrix
H	0005829	cellular_component	cytosol
H	0006869	biological_process	lipid transport
H	0008289	molecular_function	lipid binding
H	0015485	molecular_function	cholesterol binding
H	0015908	biological_process	fatty acid transport
H	0015909	biological_process	long-chain fatty acid transport
H	0016209	molecular_function	antioxidant activity
H	0019216	biological_process	regulation of lipid metabolic process
H	0019433	biological_process	triglyceride catabolic process
H	0032934	molecular_function	sterol binding
H	0036042	molecular_function	long-chain fatty acyl-CoA binding
H	0042167	biological_process	heme catabolic process
H	0070062	cellular_component	extracellular exosome
H	0070301	biological_process	cellular response to hydrogen peroxide
H	0071456	biological_process	cellular response to hypoxia
H	0098869	biological_process	cellular oxidant detoxification
H	0120009	biological_process	intermembrane lipid transfer
H	0120013	molecular_function	lipid transfer activity
H	0140104	molecular_function	molecular carrier activity
H	1990748	biological_process	cellular detoxification

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. GKYqLqsQeNFEaFMKAI

Chain	Residue	Details
A	GLY5-ILE22

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"3838309","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	56
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P12710","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P02692","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P12710","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---