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2F73

Crystal structure of human fatty acid binding protein 1 (FABP1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003682molecular_functionchromatin binding
A0005504molecular_functionfatty acid binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005782cellular_componentperoxisomal matrix
A0005829cellular_componentcytosol
A0008289molecular_functionlipid binding
A0015908biological_processfatty acid transport
A0016209molecular_functionantioxidant activity
A0070062cellular_componentextracellular exosome
A0070301biological_processcellular response to hydrogen peroxide
A0071456biological_processcellular response to hypoxia
A0098869biological_processcellular oxidant detoxification
A1990748biological_processcellular detoxification
B0003682molecular_functionchromatin binding
B0005504molecular_functionfatty acid binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005782cellular_componentperoxisomal matrix
B0005829cellular_componentcytosol
B0008289molecular_functionlipid binding
B0015908biological_processfatty acid transport
B0016209molecular_functionantioxidant activity
B0070062cellular_componentextracellular exosome
B0070301biological_processcellular response to hydrogen peroxide
B0071456biological_processcellular response to hypoxia
B0098869biological_processcellular oxidant detoxification
B1990748biological_processcellular detoxification
C0003682molecular_functionchromatin binding
C0005504molecular_functionfatty acid binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005782cellular_componentperoxisomal matrix
C0005829cellular_componentcytosol
C0008289molecular_functionlipid binding
C0015908biological_processfatty acid transport
C0016209molecular_functionantioxidant activity
C0070062cellular_componentextracellular exosome
C0070301biological_processcellular response to hydrogen peroxide
C0071456biological_processcellular response to hypoxia
C0098869biological_processcellular oxidant detoxification
C1990748biological_processcellular detoxification
D0003682molecular_functionchromatin binding
D0005504molecular_functionfatty acid binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005782cellular_componentperoxisomal matrix
D0005829cellular_componentcytosol
D0008289molecular_functionlipid binding
D0015908biological_processfatty acid transport
D0016209molecular_functionantioxidant activity
D0070062cellular_componentextracellular exosome
D0070301biological_processcellular response to hydrogen peroxide
D0071456biological_processcellular response to hypoxia
D0098869biological_processcellular oxidant detoxification
D1990748biological_processcellular detoxification
E0003682molecular_functionchromatin binding
E0005504molecular_functionfatty acid binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005782cellular_componentperoxisomal matrix
E0005829cellular_componentcytosol
E0008289molecular_functionlipid binding
E0015908biological_processfatty acid transport
E0016209molecular_functionantioxidant activity
E0070062cellular_componentextracellular exosome
E0070301biological_processcellular response to hydrogen peroxide
E0071456biological_processcellular response to hypoxia
E0098869biological_processcellular oxidant detoxification
E1990748biological_processcellular detoxification
F0003682molecular_functionchromatin binding
F0005504molecular_functionfatty acid binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005782cellular_componentperoxisomal matrix
F0005829cellular_componentcytosol
F0008289molecular_functionlipid binding
F0015908biological_processfatty acid transport
F0016209molecular_functionantioxidant activity
F0070062cellular_componentextracellular exosome
F0070301biological_processcellular response to hydrogen peroxide
F0071456biological_processcellular response to hypoxia
F0098869biological_processcellular oxidant detoxification
F1990748biological_processcellular detoxification
G0003682molecular_functionchromatin binding
G0005504molecular_functionfatty acid binding
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005782cellular_componentperoxisomal matrix
G0005829cellular_componentcytosol
G0008289molecular_functionlipid binding
G0015908biological_processfatty acid transport
G0016209molecular_functionantioxidant activity
G0070062cellular_componentextracellular exosome
G0070301biological_processcellular response to hydrogen peroxide
G0071456biological_processcellular response to hypoxia
G0098869biological_processcellular oxidant detoxification
G1990748biological_processcellular detoxification
H0003682molecular_functionchromatin binding
H0005504molecular_functionfatty acid binding
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005782cellular_componentperoxisomal matrix
H0005829cellular_componentcytosol
H0008289molecular_functionlipid binding
H0015908biological_processfatty acid transport
H0016209molecular_functionantioxidant activity
H0070062cellular_componentextracellular exosome
H0070301biological_processcellular response to hydrogen peroxide
H0071456biological_processcellular response to hypoxia
H0098869biological_processcellular oxidant detoxification
H1990748biological_processcellular detoxification
Functional Information from PROSITE/UniProt
site_idPS00214
Number of Residues18
DetailsFABP Cytosolic fatty-acid binding proteins signature. GKYqLqsQeNFEaFMKAI
ChainResidueDetails
AGLY5-ILE22

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:3838309
ChainResidueDetails
AMET1
BMET1
CMET1
DMET1
EMET1
FMET1
GMET1
HMET1

site_idSWS_FT_FI2
Number of Residues16
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER11
ESER56
FSER11
FSER56
GSER11
GSER56
HSER11
HSER56
ASER56
BSER11
BSER56
CSER11
CSER56
DSER11
DSER56
ESER11

site_idSWS_FT_FI3
Number of Residues56
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P12710
ChainResidueDetails
ALYS31
BLYS46
BLYS57
BLYS78
BLYS90
BLYS121
CLYS31
CLYS36
CLYS46
CLYS57
CLYS78
ALYS36
CLYS90
CLYS121
DLYS31
DLYS36
DLYS46
DLYS57
DLYS78
DLYS90
DLYS121
ELYS31
ALYS46
ELYS36
ELYS46
ELYS57
ELYS78
ELYS90
ELYS121
FLYS31
FLYS36
FLYS46
FLYS57
ALYS57
FLYS78
FLYS90
FLYS121
GLYS31
GLYS36
GLYS46
GLYS57
GLYS78
GLYS90
GLYS121
ALYS78
HLYS31
HLYS36
HLYS46
HLYS57
HLYS78
HLYS90
HLYS121
ALYS90
ALYS121
BLYS31
BLYS36

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P02692
ChainResidueDetails
ASER39
BSER39
CSER39
DSER39
ESER39
FSER39
GSER39
HSER39

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR51
BTHR51
CTHR51
DTHR51
ETHR51
FTHR51
GTHR51
HTHR51

site_idSWS_FT_FI6
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P12710
ChainResidueDetails
ASER100
BSER100
CSER100
DSER100
ESER100
FSER100
GSER100
HSER100

237735

PDB entries from 2025-06-18

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