2F6N

Crystal structure of PHD finger-linker-bromodomain fragment of human BPTF in the free form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0016589	cellular_component	NURF complex
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0016589	cellular_component	NURF complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	CYS11
A	CYS13
A	HIS34
A	CYS37

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1002

Chain	Residue
A	CYS26
A	CYS29
A	CYS53
A	CYS56

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1003

Chain	Residue
B	CYS13
B	HIS34
B	CYS37
B	CYS11

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1004

Chain	Residue
B	CYS26
B	CYS29
B	CYS53
B	CYS56

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. AwpFlepvDpndap..DYYgvIkepMdlatMeervqrry..Yekltefvadmtk.IfdNCryY

Chain	Residue	Details
A	ALA90-TYR147

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site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CiCktPYdeskfyigC

Chain	Residue	Details
A	CYS11-CYS26

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site_id	PS01359
Number of Residues	46
Details	ZF_PHD_1 Zinc finger PHD-type signature. Ci.Cktpydeskfy...................................IgCdr..Cqnw.YHgrCvgilqseaelide................................YvCpqC

Chain	Residue	Details
A	CYS11-CYS56

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	102
Details	ZN_FING: PHD-type 2 => ECO:0000255|PROSITE-ProRule:PRU00146

Chain	Residue	Details
A	LYS8-THR59
B	LYS8-THR59

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site_id	SWS_FT_FI2
Number of Residues	8
Details	SITE: Histone H3K4me3 binding

Chain	Residue	Details
A	TYR10
A	TYR17
A	TYR23
A	TRP32
B	TYR10
B	TYR17
B	TYR23
B	TRP32

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